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Query: NC_011248:23500:4050 Borrelia duttonii Ly plasmid pl35, complete sequence

Start: 4050, End: 5204, Length: 1155

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011256:37617:4338143381444541074Borrelia duttonii Ly plasmid pl70, complete sequencevlp protein, beta subfamily2e-50199
NC_011251:25946:3439334393354511059Borrelia duttonii Ly plasmid pl41, complete sequencevlp protein, beta subfamily4e-48192
NC_011256:37617:5954159541606201080Borrelia duttonii Ly plasmid pl70, complete sequencevlp protein, beta subfamily3e-43176
NC_011264:11018:2331423314246001287Borrelia duttonii Ly plasmid pl32, complete sequencevlp protein, beta subfamily7e-26118