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Query: NC_011248:23500:3114 Borrelia duttonii Ly plasmid pl35, complete sequence

Start: 3114, End: 3941, Length: 828

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011264:11018:122911229112935645Borrelia duttonii Ly plasmid pl32, complete sequencevsp protein8e-43174
NC_011262:13649:220112201122619609Borrelia duttonii Ly plasmid pl31, complete sequencevsp protein9e-39160
NC_011256:37617:560775607756736660Borrelia duttonii Ly plasmid pl70, complete sequencevsp protein5e-37154
NC_011256:37617:455564555646215660Borrelia duttonii Ly plasmid pl70, complete sequencevsp protein6e-35147
NC_011256:37617:546015460155206606Borrelia duttonii Ly plasmid pl70, complete sequencevsp protein1e-31136
NC_011250:1:529352935670378Borrelia duttonii Ly plasmid pl40, complete sequence6e-1168.2