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Query: NC_011248:23500:2538 Borrelia duttonii Ly plasmid pl35, complete sequence

Start: 2538, End: 2792, Length: 255

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011248:23500:111741117411431258Borrelia duttonii Ly plasmid pl35, complete sequence3e-0754.3
NC_011256:37617:533305333053888559Borrelia duttonii Ly plasmid pl70, complete sequence2e-0754.3
NC_011244:1:11420420Borrelia recurrentis A1, complete genome2e-0754.7
NC_011229:1:7068706881651098Borrelia duttonii Ly, complete genomevlp protein, alpha subfamily5e-1063.2
NC_011244:1:2174217432951122Borrelia recurrentis A1, complete genomevlp protein, alpha subfamily4e-1063.5
NC_011250:1:5757575768481092Borrelia duttonii Ly plasmid pl40, complete sequencevlp protein, alpha subfamily7e-1269.3
NC_011250:1:2769276938991131Borrelia duttonii Ly plasmid pl40, complete sequencevlp protein, alpha subfamily3e-1270.5
NC_011264:11018:3562356246501089Borrelia duttonii Ly plasmid pl32, complete sequencevlp protein, alpha subfamily2e-0857.8