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Query: NC_011248:23500:10346 Borrelia duttonii Ly plasmid pl35, complete sequence

Start: 10346, End: 11430, Length: 1085

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011250:1:5757575768481092Borrelia duttonii Ly plasmid pl40, complete sequencevlp protein, alpha subfamily1e-118426
NC_011250:1:2769276938991131Borrelia duttonii Ly plasmid pl40, complete sequencevlp protein, alpha subfamily2e-50200
NC_011264:11018:3562356246501089Borrelia duttonii Ly plasmid pl32, complete sequencevlp protein, alpha subfamily7e-45181
NC_011229:1:7068706881651098Borrelia duttonii Ly, complete genomevlp protein, alpha subfamily9e-42171
NC_011244:1:2174217432951122Borrelia recurrentis A1, complete genomevlp protein, alpha subfamily4e-33142
NC_011251:1:87528752100021251Borrelia duttonii Ly plasmid pl41, complete sequencevlp protein2e-1583.6
NC_011251:25946:87528752100021251Borrelia duttonii Ly plasmid pl41, complete sequencevlp protein2e-1583.6
NC_011256:37617:533305333053888559Borrelia duttonii Ly plasmid pl70, complete sequence1e-1274.3
NC_011244:1:6895689579891095Borrelia recurrentis A1, complete genomevlp protein, delta subfamily3e-0756.6
NC_011250:1:706370637850788Borrelia duttonii Ly plasmid pl40, complete sequence7e-0652