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Query: NC_010723:915697 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 915697, End: 938921, Length: 23225

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003366:2286083*2286083230615620074Clostridium perfringens str. 13, complete genome0718BLASTN svgBLASTP svg
NC_008262:2169262*2169262218972120460Clostridium perfringens SM101, complete genome0694BLASTN svgBLASTP svg
NC_014393:1782811*1782811180519922389Clostridium cellulovorans 743B chromosome, complete genome5e-122446BLASTN svgBLASTP svg
NC_020291:795500*79550085457259073Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome4e-107396BLASTN svgBLASTP svg
NC_021182:2219286*2219286224215022865Clostridium pasteurianum BC1, complete genome5e-88333BLASTN svgBLASTP svg
NC_010674:33620713362071338633124261Clostridium botulinum B str. Eklund 17B, complete genome9e-65256BLASTN svgBLASTP svg
NC_010674:16729901672990169323120242Clostridium botulinum B str. Eklund 17B, complete genome3e-52214BLASTN svgBLASTP svg
NC_019970:1991944*1991944200962917686Thermoanaerobacterium thermosaccharolyticum M0795, complete genome1e-51212BLASTN svgBLASTP svg
NC_010674:3581044*3581044360559924556Clostridium botulinum B str. Eklund 17B, complete genome2e-50208BLASTN svgBLASTP svg
NC_010674:11244311124431114553121101Clostridium botulinum B str. Eklund 17B, complete genome1e-48202BLASTN svgBLASTP svg
NC_010723:22693722269372228916119790Clostridium botulinum E3 str. Alaska E43, complete genome3e-43184BLASTN svgBLASTP svg
NC_010723:80121580121582512923915Clostridium botulinum E3 str. Alaska E43, complete genome1e-29139BLASTN svgBLASTP svg
NC_010674:82819182819184720219012Clostridium botulinum B str. Eklund 17B, complete genome1e-29139BLASTN svgBLASTP svg
NC_004545:15650*156506959953950Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genome1e-29139BLASTN svgBLASTP svg
NC_011661:1332309*1332309136399631688Dictyoglomus turgidum DSM 6724, complete genome2e-28135BLASTN svgBLASTP svg
NC_010723:10143341014334103372419391Clostridium botulinum E3 str. Alaska E43, complete genome6e-26127BLASTN svgBLASTP svg
NC_012034:802453*80245382393021478Anaerocellum thermophilum DSM 6725, complete genome9e-25123BLASTN svgBLASTP svg
NC_009850:1011293*1011293103921027918Arcobacter butzleri RM4018, complete genome5e-23117BLASTN svgBLASTP svg
NC_013192:1993718*1993718201717323456Leptotrichia buccalis DSM 1135, complete genome2e-22115BLASTN svgBLASTP svg
NC_015555:863173*86317388705323881Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete2e-22115BLASTN svgBLASTP svg
NC_013515:550464*55046456909918636Streptobacillus moniliformis DSM 12112, complete genome5e-1797.6BLASTN svgBLASTP svg
NC_013517:3082279*3082279310209919821Sebaldella termitidis ATCC 33386, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_019949:525249*52524956698841740Mycoplasma cynos C142 complete genome2e-1385.7BLASTN svgBLASTP svg
NC_018677:111500*11150014809936600Candidatus Portiera aleyrodidarum BT-B-HRs chromosome, complete2e-1385.7BLASTN svgBLASTP svg
NC_011296:909558*90955893630226745Thermodesulfovibrio yellowstonii DSM 11347, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_007644:626992*62699269973472743Moorella thermoacetica ATCC 39073, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_014448:487381*48738151116023780Mycoplasma hyorhinis HUB-1 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_010003:795355*79535584173746383Petrotoga mobilis SJ95, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_015711:8852850*8852850887609923250Myxococcus fulvus HW-1 chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_010723:28738862873886289437620491Clostridium botulinum E3 str. Alaska E43, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010674:24352412435241245936424124Clostridium botulinum B str. Eklund 17B, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_013171:1194500*1194500122104426545Anaerococcus prevotii DSM 20548, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010723:3499291*3499291352129922009Clostridium botulinum E3 str. Alaska E43, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015318:249445*24944527619526751Hippea maritima DSM 10411 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_013316:3056925*3056925307934422420Clostridium difficile R20291, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_010674:311378*31137833031418937Clostridium botulinum B str. Eklund 17B, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_009089:3142976*3142976316557022595Clostridium difficile 630, complete genome7e-0763.9BLASTN svgBLASTP svg