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Query: NC_010723:298954 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 298954, End: 317709, Length: 18756

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010674:311378*31137833031418937Clostridium botulinum B str. Eklund 17B, complete genome04159BLASTN svgBLASTP svg
NC_020291:27023427023430031730084Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome01207BLASTN svgBLASTP svg
NC_020291:23185323185325026518413Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome0918BLASTN svgBLASTP svg
NC_014393:1590893*1590893163877247880Clostridium cellulovorans 743B chromosome, complete genome2e-43184BLASTN svgBLASTP svg
NC_003030:3301342*3301342332018518844Clostridium acetobutylicum ATCC 824, complete genome5e-38167BLASTN svgBLASTP svg
NC_015687:3302372*3302372332181219441Clostridium acetobutylicum DSM 1731 chromosome, complete genome5e-38167BLASTN svgBLASTP svg
NC_012563:39218593921859394111319255Clostridium botulinum A2 str. Kyoto, complete genome2e-37165BLASTN svgBLASTP svg
NC_014328:4387303*4387303445852771225Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-35159BLASTN svgBLASTP svg
NC_010520:37538753753875377298819114Clostridium botulinum A3 str. Loch Maree, complete genome5e-35157BLASTN svgBLASTP svg
NC_010516:37243123724312374347419163Clostridium botulinum B1 str. Okra, complete genome3e-30141BLASTN svgBLASTP svg
NC_008261:29209992920999294008119083Clostridium perfringens ATCC 13124, complete genome3e-27131BLASTN svgBLASTP svg
NC_004557:26771552677155270388226728Clostridium tetani E88, complete genome1e-26129BLASTN svgBLASTP svg
NC_018607:15059081505908154680040893Brachyspira pilosicoli B2904 chromosome, complete genome4e-23117BLASTN svgBLASTP svg
NC_014330:19544719544722875533309Brachyspira pilosicoli 95/1000 chromosome, complete genome2e-22115BLASTN svgBLASTP svg
NC_012225:12134211213421123659923179Brachyspira hyodysenteriae WA1, complete genome7e-22113BLASTN svgBLASTP svg
NC_018604:12639271263927128817424248Brachyspira pilosicoli WesB complete genome1e-20109BLASTN svgBLASTP svg
NC_009437:1481064*1481064150445323390Caldicellulosiruptor saccharolyticus DSM 8903, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_014150:25012992501299252472923431Brachyspira murdochii DSM 12563 chromosome, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_014328:22034372203437222518421748Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_019970:8938*89382966920732Thermoanaerobacterium thermosaccharolyticum M0795, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_014410:8694*86942877520082Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,2e-1385.7BLASTN svgBLASTP svg
NC_014614:47857847857849868920112Clostridium sticklandii, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_019978:22461922461924698422366Halobacteroides halobius DSM 5150, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_015555:447844782276918292Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete9e-1279.8BLASTN svgBLASTP svg
NC_015958:2206032*2206032223846032429Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_014654:15816891581689160373022042Halanaerobium sp. 'sapolanicus' chromosome, complete genome1e-1075.8BLASTN svgBLASTP svg
NC_013316:120759*12075915711036352Clostridium difficile R20291, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_009089:117980*11798016311645137Clostridium difficile 630, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_004193:241480*24148026554624067Oceanobacillus iheyensis HTE831, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_013517:104480*10448012509920620Sebaldella termitidis ATCC 33386, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_014909:662500*66250068970227203Candidatus Blochmannia vafer str. BVAF chromosome, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_009850:1011293*1011293103921027918Arcobacter butzleri RM4018, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_003030:95918*9591811738721470Clostridium acetobutylicum ATCC 824, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_014538:19425001942500196030417805Thermoanaerobacter sp. X513 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_015687:95918*9591811738721470Clostridium acetobutylicum DSM 1731 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_019908:43600043600045549719498Brachyspira pilosicoli P43/6/78 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_015958:11511115113009918589Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_000909:1517461*1517461154009922639Methanocaldococcus jannaschii DSM 2661, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010516:20640272064027208498120955Clostridium botulinum B1 str. Okra, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010520:21715842171584219449022907Clostridium botulinum A3 str. Loch Maree, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_012563:22030372203037222476521729Clostridium botulinum A2 str. Kyoto, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_013887:24523624523628003834803Methanocaldococcus sp. FS406-22 chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_003869:14153*141533317319021Thermoanaerobacter tengcongensis MB4, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_012121:15781901578190160311524926Staphylococcus carnosus subsp. carnosus TM300, complete genome9e-0660BLASTN svgBLASTP svg
NC_010003:17245001724500174259918100Petrotoga mobilis SJ95, complete genome9e-0660BLASTN svgBLASTP svg
NC_009922:25560332556033258448628454Alkaliphilus oremlandii OhILAs, complete genome9e-0660BLASTN svgBLASTP svg
NC_003869:20990002099000211791718918Thermoanaerobacter tengcongensis MB4, complete genome9e-0660BLASTN svgBLASTP svg