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Query: NC_010723:2231834 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2231834, End: 2254536, Length: 22703

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010674:24352412435241245936424124Clostridium botulinum B str. Eklund 17B, complete genome05864BLASTN svgBLASTP svg
NC_010674:24171992417199243509917901Clostridium botulinum B str. Eklund 17B, complete genome0702BLASTN svgBLASTP svg
NC_021182:29210002921000295537334374Clostridium pasteurianum BC1, complete genome5e-57230BLASTN svgBLASTP svg
NC_008262:22424322242432226666224231Clostridium perfringens SM101, complete genome1e-54222BLASTN svgBLASTP svg
NC_003366:23561482356148238179725650Clostridium perfringens str. 13, complete genome7e-50206BLASTN svgBLASTP svg
NC_008593:10605481060548108560225055Clostridium novyi NT, complete genome1e-39172BLASTN svgBLASTP svg
NC_008262:38132338132340409922777Clostridium perfringens SM101, complete genome4e-33151BLASTN svgBLASTP svg
NC_008261:38129738129740188720591Clostridium perfringens ATCC 13124, complete genome4e-33151BLASTN svgBLASTP svg
NC_010723:14650971465097149459929503Clostridium botulinum E3 str. Alaska E43, complete genome6e-32147BLASTN svgBLASTP svg
NC_010520:11460001146000116884922850Clostridium botulinum A3 str. Loch Maree, complete genome8e-22113BLASTN svgBLASTP svg
NC_003454:20807052080705210460123897Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete5e-20107BLASTN svgBLASTP svg
NC_010674:11244311124431114553121101Clostridium botulinum B str. Eklund 17B, complete genome5e-20107BLASTN svgBLASTP svg
NC_010723:10840001084000110630222303Clostridium botulinum E3 str. Alaska E43, complete genome5e-20107BLASTN svgBLASTP svg
NC_010516:35450173545017356809923083Clostridium botulinum B1 str. Okra, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_013515:347671*34767139636648696Streptobacillus moniliformis DSM 12112, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_008593:2020473*2020473204359923127Clostridium novyi NT, complete genome7e-1383.8BLASTN svgBLASTP svg
NC_019978:39000*390005838419385Halobacteroides halobius DSM 5150, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_015519:26057092605709262542119713Tepidanaerobacter sp. Re1 chromosome, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_010001:1452167*1452167147370421538Clostridium phytofermentans ISDg, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_011565:620801*62080165959938799Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,3e-0971.9BLASTN svgBLASTP svg
NC_020409:62179262179268410962318Desulfovibrio piezophilus str. nov C1TLV30 chromosome, complete3e-0661.9BLASTN svgBLASTP svg
NC_020207:13465791346579138861142033Enterococcus faecium NRRL B-2354, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_015565:824448*82444884309918652Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete3e-0661.9BLASTN svgBLASTP svg