Pre_GI: BLASTN Hits

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Query: NC_010723:2082750 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2082750, End: 2104599, Length: 21850

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010674:21857042185704221026824565Clostridium botulinum B str. Eklund 17B, complete genome09918BLASTN svgBLASTP svg
NC_008261:13328641332864135143618573Clostridium perfringens ATCC 13124, complete genome01267BLASTN svgBLASTP svg
NC_003366:11226541122654114059917946Clostridium perfringens str. 13, complete genome01243BLASTN svgBLASTP svg
NC_008262:11395001139500116059921100Clostridium perfringens SM101, complete genome01235BLASTN svgBLASTP svg
NC_013517:1055854*10558541161670105817Sebaldella termitidis ATCC 33386, complete genome4e-42180BLASTN svgBLASTP svg
NC_014538:985339985339100713721799Thermoanaerobacter sp. X513 chromosome, complete genome2e-34155BLASTN svgBLASTP svg
NC_019970:20804192080419209909918681Thermoanaerobacterium thermosaccharolyticum M0795, complete genome8e-25123BLASTN svgBLASTP svg
NC_014654:11131161113116113933826223Halanaerobium sp. 'sapolanicus' chromosome, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_020291:49100049100051106420065Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010674:14965001496500152566029161Clostridium botulinum B str. Eklund 17B, complete genome4e-0867.9BLASTN svgBLASTP svg