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Query: NC_010723:1014334 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1014334, End: 1033724, Length: 19391

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_020291:48158534815853483840422552Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome02097BLASTN svgBLASTP svg
NC_014328:11084791108479112609917621Clostridium ljungdahlii ATCC 49587 chromosome, complete genome7e-90339BLASTN svgBLASTP svg
NC_008593:22818962281896230590024005Clostridium novyi NT, complete genome4e-42180BLASTN svgBLASTP svg
NC_012225:22477962247796226763119836Brachyspira hyodysenteriae WA1, complete genome3e-27131BLASTN svgBLASTP svg
NC_010723:915697*91569793892123225Clostridium botulinum E3 str. Alaska E43, complete genome5e-26127BLASTN svgBLASTP svg
NC_010674:11244311124431114553121101Clostridium botulinum B str. Eklund 17B, complete genome5e-26127BLASTN svgBLASTP svg
NC_003030:303812*30381236254758736Clostridium acetobutylicum ATCC 824, complete genome3e-24121BLASTN svgBLASTP svg
NC_015687:303810*30381036254358734Clostridium acetobutylicum DSM 1731 chromosome, complete genome3e-24121BLASTN svgBLASTP svg
NC_021182:162236*16223618461322378Clostridium pasteurianum BC1, complete genome3e-24121BLASTN svgBLASTP svg
NC_010674:3581044*3581044360559924556Clostridium botulinum B str. Eklund 17B, complete genome7e-22113BLASTN svgBLASTP svg
NC_018604:2350054*2350054237001019957Brachyspira pilosicoli WesB complete genome3e-21111BLASTN svgBLASTP svg
NC_018607:2231975*2231975225336921395Brachyspira pilosicoli B2904 chromosome, complete genome3e-21111BLASTN svgBLASTP svg
NC_010674:33620713362071338633124261Clostridium botulinum B str. Eklund 17B, complete genome3e-21111BLASTN svgBLASTP svg
NC_010184:1017000*1017000103592118922Bacillus weihenstephanensis KBAB4, complete genome1e-20109BLASTN svgBLASTP svg
NC_021182:2422226*2422226244735325128Clostridium pasteurianum BC1, complete genome7e-19103BLASTN svgBLASTP svg
NC_019908:2312194*2312194233353121338Brachyspira pilosicoli P43/6/78 chromosome, complete genome7e-19103BLASTN svgBLASTP svg
NC_014330:888366*88836691146423099Brachyspira pilosicoli 95/1000 chromosome, complete genome7e-19103BLASTN svgBLASTP svg
NC_014964:55791055791057776519856Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete1e-1799.6BLASTN svgBLASTP svg
NC_005957:1037205*1037205105595618752Bacillus thuringiensis serovar konkukian str. 97-27, complete4e-1797.6BLASTN svgBLASTP svg
NC_010674:16729901672990169323120242Clostridium botulinum B str. Eklund 17B, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_004722:10085001008500103115022651Bacillus cereus ATCC 14579, complete genome6e-1693.7BLASTN svgBLASTP svg
NC_010336:1117325*1117325114783030506Francisella philomiragia subsp. philomiragia ATCC 25017, complete6e-1693.7BLASTN svgBLASTP svg
NC_014654:1*12910529105Halanaerobium sp. 'sapolanicus' chromosome, complete genome6e-1693.7BLASTN svgBLASTP svg
NC_003030:1811820*1811820183505323234Clostridium acetobutylicum ATCC 824, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_003997:1007139*1007139102671019572Bacillus anthracis str. Ames, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_005945:1008000*1008000102660318604Bacillus anthracis str. Sterne, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_006274:1040836*1040836105962518790Bacillus cereus E33L, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_007530:1007140*1007140102671019571Bacillus anthracis str. 'Ames Ancestor', complete genome1e-1489.7BLASTN svgBLASTP svg
NC_008600:1042477*1042477106188519409Bacillus thuringiensis str. Al Hakam, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_015687:1811573*1811573183463823066Clostridium acetobutylicum DSM 1731 chromosome, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_004557:24750302475030249953624507Clostridium tetani E88, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_019978:2036779*2036779205929022512Halobacteroides halobius DSM 5150, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_015275:566000*56600059144025441Clostridium lentocellum DSM 5427 chromosome, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_002952:13490061349006137209923094Staphylococcus aureus subsp. aureus MRSA252, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_003923:47374347374349308819346Staphylococcus aureus subsp. aureus MW2, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_011772:1011220*1011220103272721508Bacillus cereus G9842, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_019978:14777241477724150009922376Halobacteroides halobius DSM 5150, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_009465:938378*93837897956141184Candidatus Vesicomyosocius okutanii HA, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_014122:39385639385641638122526Methanocaldococcus infernus ME chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_002745:48750048750050530117802Staphylococcus aureus subsp. aureus N315, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_002758:51124751124753009918853Staphylococcus aureus subsp. aureus Mu50, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_002952:49450049450051409919600Staphylococcus aureus subsp. aureus MRSA252, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_004193:25220002522000254434522346Oceanobacillus iheyensis HTE831, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_004193:3215500*3215500323352618027Oceanobacillus iheyensis HTE831, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_006570:141966*14196617413932174Francisella tularensis subsp. tularensis Schu 4, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_008245:141982*14198217415532174Francisella tularensis subsp. tularensis FSC 198, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010677:214712*21471224609931388Francisella tularensis subsp. mediasiatica FSC147, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010723:80121580121582512923915Clostridium botulinum E3 str. Alaska E43, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_010520:20615022061502208422422723Clostridium botulinum A3 str. Loch Maree, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_010516:19995001999500201784518346Clostridium botulinum B1 str. Okra, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008262:28245032824503284819823696Clostridium perfringens SM101, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_007205:424500*42450044975125252Candidatus Pelagibacter ubique HTCC1062, complete genome2e-0661.9BLASTN svgBLASTP svg