Pre_GI: BLASTP Hits

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Query: NC_010723:622928:638577 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 638577, End: 639092, Length: 516

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:658596:673380673380673895516Clostridium botulinum B str. Eklund 17B, complete genomeGnaT-family acetyltransferase8e-89325
NC_015425:641000:645887645887646396510Clostridium botulinum BKT015925 chromosome, complete genomeGNAT family acetyltransferase5e-34143
NC_004129:3965947:3973732397373239748711140Pseudomonas fluorescens Pf-5, complete genomeacetyltransferase, GNAT family family7e-25113
NC_015410:2698572:270645827064582707378921Pseudomonas mendocina NK-01 chromosome, complete genomeacetyltransferase1e-24112
NC_014910:2585747:259558825955882596499912Alicycliphilus denitrificans BC chromosome, complete genomegcn5-related n-acetyltransferase1e-22105
NC_016048:522637:542125542125542742618Oscillibacter valericigenes Sjm18-20, complete genomeputative acetyltransferase8e-1993.2
NC_013406:2207520:221452822145282215067540Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase2e-0858.2
NC_006138:23902:408104081041337528Desulfotalea psychrophila LSv54, complete genomesimilar to acetyltransferase1e-0652.8
NC_016582:9664000:967312196731219673612492Streptomyces bingchenggensis BCW-1 chromosome, complete genomeN-acetyltransferase GCN52e-0652.4
NC_011772:2860000:287941728794172879956540Bacillus cereus G9842, complete genomebifunctional AAC/APH2e-0651.6
NC_016584:487613:501601501601502173573Desulfosporosinus orientis DSM 765 chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase6e-0650.1