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Query: NC_010723:622928:624804 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 624804, End: 626303, Length: 1500

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:658596:6595986595986610971500Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein0960
NC_015572:4576778:4599516459951646010241509Methylomonas methanica MC09 chromosome, complete genomeAll-trans-retinol 13,14-reductase8e-39162
NC_016593:1814500:1832956183295618344521497Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completehypothetical protein5e-37155
NC_007776:1340741:1359648135964813612041557Synechococcus sp. JA-2-3B'a(2-13), complete genomecarotenoid isomerase5e-31135
NC_010296:1081728:1081728108172810832391512Microcystis aeruginosa NIES-843, complete genomecarotene isomerase1e-26121
NC_005071:1111605:1131223113122311327851563Prochlorococcus marinus str. MIT 9313, complete genomeputative carotenoid isomerase2e-26120
NC_016109:7445603:7445603744560374473811779Kitasatospora setae KM-6054, complete genomeputative oxidoreductase1e-21104
NC_010794:2071858:2080718208071820823371620Methylacidiphilum infernorum V4, complete genomePhytoene dehydrogenase or related enzyme4e-2099.8
NC_019940:3267436:3293093329309332946221530Thioflavicoccus mobilis 8321 chromosome, complete genomephytoene desaturase3e-1790.1
NC_019757:5931500:5947877594787759493911515Cylindrospermum stagnale PCC 7417, complete genomeC-3',4' desaturase CrtD1e-1688.2
NC_012032:1827244:1845267184526718469281662Chloroflexus sp. Y-400-fl, complete genomeFAD dependent oxidoreductase3e-1583.6
NC_010175:1825878:1843901184390118455621662Chloroflexus aurantiacus J-10-fl, complete genomeFAD dependent oxidoreductase3e-1583.6
NC_005071:1643557:1652534165253416536221089Prochlorococcus marinus str. MIT 9313, complete genomeNAD binding site5e-1582.8
NC_015152:2528399:2529045252904525305201476Spirochaeta sp. Buddy chromosome, complete genomeFAD dependent oxidoreductase2e-1480.9
NC_014829:4293583:4310703431070343121661464Bacillus cellulosilyticus DSM 2522 chromosome, complete genomephytoene desaturase2e-1274.3
NC_007643:578808:5788085788085803311524Rhodospirillum rubrum ATCC 11170, complete genomePhytoene desaturase3e-1273.6
NC_011729:4073761:4074417407441740760601644Cyanothece sp. PCC 7424 chromosome, complete genomeFAD dependent oxidoreductase8e-1272.4
NC_014934:4834000:4851649485164948533421694Cellulophaga algicola DSM 14237 chromosome, complete genome4e-1170.1
NC_014623:1074299:1076428107642810779991572Stigmatella aurantiaca DW4/3-1 chromosome, complete genomephytoene dehydrogenase1e-1068.2
NC_009921:3455783:3470487347048734720401554Frankia sp. EAN1pec, complete genomeFAD dependent oxidoreductase1e-0964.7
NC_012623:799614:8140608140608154691410Sulfolobus islandicus Y.N.15.51 chromosome, complete genomephytoene desaturase4e-0963.2
NC_015275:443213:4578544578544593471494Clostridium lentocellum DSM 5427 chromosome, complete genomephytoene desaturase5e-0963.2
NC_015064:1021483:1021483102148310230391557Acidobacterium sp. MP5ACTX9 chromosome, complete genomephytoene desaturase3e-0757