Pre_GI: BLASTP Hits

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Query: NC_010723:371741:386883 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 386883, End: 387722, Length: 840

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:370629:391488391488392327840Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-144511
NC_003909:4951444:496368149636814964463783Bacillus cereus ATCC 10987, complete genomehypothetical protein6e-1271.6
NC_016779:4969626:497775649777564978538783Bacillus cereus F837/76 chromosome, complete genometransmembrane protein2e-1169.7
NC_012472:5015621:502376450237645024546783Bacillus cereus 03BB102, complete genomehypothetical protein3e-1169.3
NC_008600:5005345:501348850134885014270783Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein3e-1169.3
NC_011969:4945441:495488449548844955666783Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-1168.9
NC_014171:5068500:507708450770845077866783Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-1066.6
NC_011725:5169135:518142251814225182204783Bacillus cereus B4264 chromosome, complete genomehypothetical protein4e-1065.5
NC_016771:4962795:497223849722384973020783Bacillus cereus NC7401, complete genomehypothetical protein2e-0963.2
NC_011658:5007691:501991550199155020697783Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-0963.2