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Query: NC_010723:371741:375524 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 375524, End: 376156, Length: 633

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:370629:380146380146380778633Clostridium botulinum B str. Eklund 17B, complete genomeredox-sensing transcriptional repressor rex3e-104377
NC_009617:385000:386403386403387038636Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeredox-sensing transcriptional repressor Rex3e-85314
NC_020291:491000:500649500649501284636Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeredox-sensing transcriptional repressor Rex1e-83309
NC_008262:2498000:251243625124362513074639Clostridium perfringens SM101, complete genomeDNA-binding protein8e-79293
NC_004557:2552418:256762825676282568263636Clostridium tetani E88, complete genomeredox-sensing transcriptional repressor Rex5e-75280
NC_014393:3650957:366373136637313664354624Clostridium cellulovorans 743B chromosome, complete genomeCoA-binding domain-containing protein2e-72271
NC_021182:1473535:147827514782751478916642Clostridium pasteurianum BC1, complete genomeAT-rich DNA-binding protein3e-71268
NC_012563:3729817:375944237594423760074633Clostridium botulinum A2 str. Kyoto, complete genometranscriptional regulator, Rex family5e-69260
NC_009495:3502000:351737235173723518004633Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeredox-sensing transcriptional repressor Rex5e-69260
NC_009697:3463736:349336034933603493992633Clostridium botulinum A str. ATCC 19397 chromosome, completeredox-sensing transcriptional repressor Rex5e-69260
NC_009699:3581376:361100336110033611635633Clostridium botulinum F str. Langeland chromosome, complete genomeredox-sensing transcriptional repressor Rex5e-69260
NC_017297:3594000:360961736096173610249633Clostridium botulinum F str. 230613 chromosome, complete genometranscriptional regulator, Rex family5e-69260
NC_010520:3580000:359457635945763595208633Clostridium botulinum A3 str. Loch Maree, complete genometranscriptional regulator, Rex family1e-68258
NC_016048:2055199:205908420590842059713630Oscillibacter valericigenes Sjm18-20, complete genomeredox-sensing transcriptional repressor Rex9e-45179
NC_011899:2165814:218852321885232189170648Halothermothrix orenii H 168, complete genomeredox-sensing transcriptional repressor Rex1e-41169
NC_014654:391201:408863408863409510648Halanaerobium sp. 'sapolanicus' chromosome, complete genomeCoA-binding domain protein1e-40166
NC_014377:669216:687535687535688167633Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCoA-binding domain protein1e-38159
NC_015873:1119500:111953511195351120170636Megasphaera elsdenii DSM 20460, complete genomeredox-sensing transcriptional repressor rex5e-38157
NC_020995:2636519:265310726531072653853747Enterococcus casseliflavus EC20, complete genomeredox-sensing transcriptional repressor rex 12e-30132
NC_015759:1117122:111977911197791120414636Weissella koreensis KACC 15510 chromosome, complete genomeredox-sensing transcriptional repressor Rex6e-29127
NC_011567:204772:224680224680225315636Anoxybacillus flavithermus WK1, complete genomeAT-rich DNA-binding protein3e-27121
NC_008025:669281:679673679673680368696Deinococcus geothermalis DSM 11300, complete genomeCoA-binding3e-27121
NC_020272:3325000:334033933403393340986648Bacillus amyloliquefaciens IT-45, complete genomeredox-sensing transcriptional repressor Rex5e-27120
NC_014376:869749:882315882315882983669Clostridium saccharolyticum WM1 chromosome, complete genomeCoA-binding domain protein1e-24112
NC_021175:964224:967037967037967684648Streptococcus oligofermentans AS 1.3089, complete genomeredox-sensing transcriptional repressor Rex2e-24112
NC_014171:235558:257804257804258433630Bacillus thuringiensis BMB171 chromosome, complete genomeredox-sensing transcriptional repressor Rex4e-24111
NC_017208:256163:258284258284258913630Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeredox-sensing transcriptional repressor Rex4e-24111
NC_007498:1848437:185937418593741860021648Pelobacter carbinolicus DSM 2380, complete genomeputative DNA-binding protein p256e-24110
NC_015601:1107961:111449311144931115116624Erysipelothrix rhusiopathiae str. Fujisawa, complete genomeredox-sensing transcriptional repressor Rex2e-23108
NC_016776:4525065:454473045447304545392663Bacteroides fragilis 638R, complete genomehypothetical protein3e-22105
NC_003228:4449072:446460144646014465263663Bacteroides fragilis NCTC 9343, complete genomeredox-sensing transcriptional repressor Rex3e-22105
NC_006347:4562242:457860545786054579261657Bacteroides fragilis YCH46, complete genomeredox-sensing transcriptional repressor Rex3e-22104
NC_014824:133065:138999138999139601603Ruminococcus albus 7 plasmid pRUMAL01, complete sequenceCoA-binding domain protein2e-2099
NC_010999:1381497:140352014035201404173654Lactobacillus casei, complete genomeRedox-sensing transcriptional repressor rex2e-1892.4
NC_013192:171000:172578172578173243666Leptotrichia buccalis DSM 1135, complete genomeRex DNA-binding domain protein8e-1890.1