Pre_GI: BLASTP Hits

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Query: NC_010723:3133302:3150467 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 3150467, End: 3151264, Length: 798

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011837:238160:239077239077239919843Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-62238
NC_009706:238160:239077239077239910834Clostridium kluyveri DSM 555 chromosome, complete genomehistidinol-phosphatase-like protein3e-62238
NC_015500:1204501:121793912179391218772834Treponema brennaborense DSM 12168 chromosome, complete genomehistidinol phosphate phosphatase HisJ family3e-62238
NC_009617:1165539:116553911655391166324786Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeHisJ family histidinol phosphate phosphatase1e-61236
NC_014721:1777644:179480917948091795609801Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehistidinol phosphate phosphatase hisj family2e-59229
NC_014657:1518721:153634615363461537146801Caldicellulosiruptor owensensis OL chromosome, complete genomehistidinol phosphate phosphatase hisj family3e-59228
NC_013517:3997448:401679140167914017627837Sebaldella termitidis ATCC 33386, complete genomehistidinol phosphate phosphatase HisJ family8e-59226
NC_015949:1180755:119790511979051198705801Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomehistidinol phosphate phosphatase HisJ family1e-57223
NC_014652:1032711:105715610571561057956801Caldicellulosiruptor hydrothermalis 108 chromosome, completehistidinol phosphate phosphatase hisj family8e-58223
NC_014392:969498:992342992342993142801Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomehistidinol phosphate phosphatase HisJ family8e-57220
NC_009437:2367842:238498223849822385782801Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeHisJ family histidinol phosphate phosphatase3e-56218
NC_004193:375416:585937585937586740804Oceanobacillus iheyensis HTE831, complete genomehistidinol phosphatase4e-56218
NC_014720:1161841:116452711645271165327801Caldicellulosiruptor kronotskyensis 2002 chromosome, completehistidinol phosphate phosphatase hisj family2e-54213
NC_012034:1783912:180118818011881801988801Anaerocellum thermophilum DSM 6725, complete genomehistidinol phosphate phosphatase HisJ family4e-54211
NC_015737:2691246:271378427137842714587804Clostridium sp. SY8519, complete genomehistidinol phosphatase3e-48192
NC_021171:4425050:444770744477074448585879Bacillus sp. 1NLA3E, complete genomehistidinol-phosphatase1e-35149
NC_014624:1349950:135345913534591354256798Eubacterium limosum KIST612 chromosome, complete genomehistidinol phosphatase9e-31134
NC_014328:1263139:128108812810881281861774Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehistidinol-phosphatase2e-27123
NC_021182:4088000:410302641030264103790765Clostridium pasteurianum BC1, complete genomehistidinol phosphate phosphatase HisJ family5e-25114
NC_015172:3160249:316121531612153161994780Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomehistidinol phosphate phosphatase HisJ family6e-22104
NC_017068:2604876:262978826297882630567780Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative histidinol phosphatase2e-21102
NC_003366:2143173:216290121629012163689789Clostridium perfringens str. 13, complete genomehypothetical protein4e-21102
NC_014483:195321:204956204956205780825Paenibacillus polymyxa E681 chromosome, complete genomeProbable histidinol-phosphatase (HolPase)6e-2097.8
NC_015942:2293455:229528622952862296152867Acidithiobacillus ferrivorans SS3 chromosome, complete genomehistidinol phosphate phosphatase HisJ family2e-1686.3
NC_008463:282565:303810303810304676867Pseudomonas aeruginosa UCBPP-PA14, complete genomehypothetical protein3e-1685.5
NC_015555:2359000:236115823611582361976819Thermoanaerobacterium xylanolyticum LX-11 chromosome, completehistidinol phosphate phosphatase HisJ family2e-1376.6
NC_008525:108687:115638115638116438801Pediococcus pentosaceus ATCC 25745, complete genomeHistidinol phosphatase related hydrolase of the PHP family2e-1375.9
NC_014410:2609588:261250226125022613320819Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,histidinol phosphate phosphatase HisJ family6e-1374.7
NC_006347:1815687:183845818384581839291834Bacteroides fragilis YCH46, complete genomeputative histidinol-phosphatase2e-1272.8
NC_014364:394899:464885464885465736852Spirochaeta smaragdinae DSM 11293 chromosome, complete genomehistidinol phosphate phosphatase HisJ family6e-1271.6
NC_014377:1512217:153235315323531533174822Thermosediminibacter oceani DSM 16646 chromosome, complete genomehistidinol phosphate phosphatase HisJ family2e-1169.7
NC_013921:2293411:230955823095582310376819Thermoanaerobacter italicus Ab9 chromosome, complete genomehistidinol phosphate phosphatase HisJ family7e-1167.8
NC_015958:2527376:2548421254842125501391719Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomePHP domain-containing protein6e-0755.1
NC_015519:924000:936205936205937032828Tepidanaerobacter sp. Re1 chromosome, complete genomehistidinol phosphate phosphatase HisJ family9e-0754.3
NC_016584:4325964:432837443283744328637264Desulfosporosinus orientis DSM 765 chromosome, complete genomePHP family phosphohydrolase, histidinol phosphatase1e-0653.5