Pre_GI: BLASTP Hits

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Query: NC_010723:3133302:3137701 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 3137701, End: 3140685, Length: 2985

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020291:5981006:5981006598100659841253120Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-66254
NC_009617:5489933:5504170550417055064042235Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein2e-25119
NC_010674:3362071:3367670336767033690161347Clostridium botulinum B str. Eklund 17B, complete genomecollagenolytic protease4e-25117
NC_010674:3362071:3375251337525133774522202Clostridium botulinum B str. Eklund 17B, complete genomecollagenolytic protease8e-25116
NC_020291:5981006:6002412600241260046402229Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein6e-24113
NC_010674:3362071:3364202336420233656351434Clostridium botulinum B str. Eklund 17B, complete genomesurface protein PspC2e-20102
NC_009617:5545477:5562693556269355644201728Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein1e-20102
NC_020291:6055282:6067952606795260696641713Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-1999
NC_009617:5489933:5500218550021855023202103Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein8e-1893.2
NC_009617:5489933:5489933548993354917231791Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein2e-1792
NC_009617:4436837:4445651444565144501414491Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeglycosyl hydrolase family 32 protein2e-1791.7
NC_010674:3362071:3372846337284633746481803Clostridium botulinum B str. Eklund 17B, complete genomesurface protein PspC5e-1790.9
NC_012468:2069238:2069238206923820711631926Streptococcus pneumoniae 70585, complete genomecholine binding protein PcpA6e-1790.5
NC_012466:2008000:2008012200801220099371926Streptococcus pneumoniae JJA, complete genomecholine binding protein PcpA6e-1790.5
NC_020291:2218425:2220952222095222260575106Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeS-layer domain-containing protein8e-1790.1
NC_009617:5489933:5508581550858155103621782Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein1e-1689.7
NC_011900:2107133:2108466210846621104511986Streptococcus pneumoniae ATCC 700669, complete genomecell surface choline binding protein PcpA9e-1789.7
NC_010582:2091138:2093339209333920953241986Streptococcus pneumoniae CGSP14, complete genomecholine binding protein PcpA9e-1789.7
NC_009617:5489933:5506727550672755081481422Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein9e-1789.7
NC_003098:1925783:1925783192578319278552073Streptococcus pneumoniae R6, complete genomeCholine-binding protein1e-1689.4
NC_020291:5981006:5985561598556159878882328Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeN-acetylmuramoyl-L-alanine amidase6e-1687
NC_009617:5545477:5560924556092455622251302Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein1e-1586.3
NC_009617:4436837:4440273444027344443794107Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeglycoside hydrolase family protein2e-1585.5
NC_013165:1665014:1665014166501416668221809Slackia heliotrinireducens DSM 20476, complete genomeglucan-binding domain-containing protein3e-1585.1
NC_020291:5981006:6005194600519460066391446Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein3e-1584.7
NC_010674:3362071:3379843337984333821312289Clostridium botulinum B str. Eklund 17B, complete genomesurface protein PspA4e-1584.3
NC_010674:2185704:2204063220406322070923030Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein6e-1584
NC_014363:645397:6753626753626777522391Olsenella uli DSM 7084 chromosome, complete genomecell wall hydrolase/autolysin6e-1583.6
NC_020291:5981006:6006967600696760087271761Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-1483.2
NC_010723:3133302:3141134314113431431912058Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC2e-1482.4
NC_010674:3362071:3366291336629133675201230Clostridium botulinum B str. Eklund 17B, complete genomecell wall binding repeat domain protein2e-1482.4
NC_010674:3619722:3624124362412436254731350Clostridium botulinum B str. Eklund 17B, complete genomesurface protein PspC2e-1482
NC_010723:2082750:2098943209894321022573315Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-1482
NC_010723:3434000:3438588343858834399401353Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC3e-1481.6
NC_020291:6055282:6066189606618960674871299Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-1481.6
NC_009617:5545477:5552462555246255542341773Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein7e-1480.1
NC_020291:1871846:1875116187511618782803165Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglucan-binding domain-containing protein1e-1379.7
NC_010674:3362071:3370438337043833719221485Clostridium botulinum B str. Eklund 17B, complete genomecollagenolytic protease2e-1378.6
NC_013165:1780321:179772817977281798678951Slackia heliotrinireducens DSM 20476, complete genomeputative cell wall binding protein3e-1378.2
NC_014498:62891:759517595176907957Streptococcus pneumoniae 670-6B chromosome, complete genomeautolysin3e-1378.2
NC_009617:5545477:5557722555772255592631542Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein3e-1378.2
NC_010723:3434000:3450540345054034516251086Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC8e-1376.6
NC_010674:3362071:3382608338260833843861779Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein8e-1376.6
NC_009617:5545477:5556427555642755576711245Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein1e-1276.6
NC_014494:47049:575725757258528957Streptococcus pneumoniae AP200 chromosome, complete genomeautolysin1e-1275.9
NC_014498:1983740:199027119902711991227957Streptococcus pneumoniae 670-6B chromosome, complete genomelytic amidase2e-1275.1
NC_010674:3362071:3377745337774533794241680Clostridium botulinum B str. Eklund 17B, complete genomecholine binding protein A2e-1275.1
NC_011900:1485650:148786414878641488820957Streptococcus pneumoniae ATCC 700669, complete genomeautolysin5e-1274.3
NC_009617:5489933:5492039549203954939881950Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein5e-1273.9
NC_020291:6055282:6061883606188360630731191Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein5e-1273.9
NC_009617:5545477:5559494555949455607591266Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein9e-1273.2
NC_020291:5981006:5996094599609459980972004Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglucan-binding domain-containing protein1e-1172.8
NC_010723:3434000:3446341344634134474711131Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC1e-1172.8
NC_020291:6055282:6064822606482260660871266Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein3e-1171.6
NC_009617:5545477:5555079555507955562961218Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein3e-1171.2
NC_010674:1986000:198708519870851987876792Clostridium botulinum B str. Eklund 17B, complete genomecollagenolytic protease4e-1171.2
NC_010674:3362071:336924033692403370151912Clostridium botulinum B str. Eklund 17B, complete genomeSpsA protein2e-1069.3
NC_015172:3095781:3102694310269431082495556Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeS-layer domain-containing protein2e-1069.3
NC_010723:3133302:3143492314349231457052214Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC2e-1068.9
NC_015172:1002872:1013311101331110181674857Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeS-layer domain-containing protein2e-1068.9
NC_015601:436822:4368224368224400883267Erysipelothrix rhusiopathiae str. Fujisawa, complete genomecholine-binding protein8e-1067
NC_009617:5489933:5496585549658554999023318Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall/surface repeat-containing protein1e-0966.2
NC_015172:1195782:1219154121915412254266273Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeFibronectin type III domain protein3e-0965.1
NC_013170:311045:3145613145613155801020Cryptobacterium curtum DSM 15641, complete genomeN-acetylmuramoyl-L-alanine amidase2e-0965.1
NC_020291:6274030:6291320629132062926241305Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeCHAP domain-containing protein,SH3 domain-containing protein,putative cell wall binding protein2e-0965.1
NC_009617:5489933:5495426549542654964931068Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall/surface repeat-containing protein3e-0964.7
NC_020291:6055282:6063178606317860644551278Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein6e-0963.9
NC_020291:6055282:6058301605830160600851785Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein5e-0963.9
NC_014376:3671441:3688315368831536896791365Clostridium saccharolyticum WM1 chromosome, complete genomeputative cell wall binding repeat-containing protein1e-0862.8
NC_020292:110284:124615124615125397783Clostridium saccharoperbutylacetonicum N1-4(HMT) plasmid Csp_135p,hypothetical protein2e-0862.4
NC_003030:1231127:1231127123112712395808454Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized protein, related to enterotoxins of other Clostridiales2e-0862.4
NC_015687:1230948:1230948123094812394018454Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein2e-0862.4
NC_017295:1228760:1228760122876012372138454Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein2e-0862.4
NC_009617:5040486:5057941505794150592871347Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein4e-0861.2
NC_010674:2328307:233068823306882331488801Clostridium botulinum B str. Eklund 17B, complete genomeputative phage lysozyme5e-0860.8
NC_014376:3671441:3687260368726036883181059Clostridium saccharolyticum WM1 chromosome, complete genomeputative cell wall binding repeat-containing protein5e-0860.8
NC_010674:2817651:282135728213572822148792Clostridium botulinum B str. Eklund 17B, complete genomecell wall binding repeat domain protein7e-0860.5
NC_020291:5981006:5991898599189859953563459Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-0759.3
NC_020291:463500:4740784740784759221845Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecell wall binding repeat-containing protein5e-0757.4
NC_020292:110284:1205131205131240583546Clostridium saccharoperbutylacetonicum N1-4(HMT) plasmid Csp_135p,hypothetical protein1e-0656.6
NC_020291:5981006:5990745599074559918091065Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein3e-0654.7
NC_009617:1487110:150244415024441503181738Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein5e-0654.3
NC_008261:576923:5807665807665854394674Clostridium perfringens ATCC 13124, complete genomecell wall binding repeat domain protein5e-0654.3
NC_014376:3796990:3799489379948938070157527Clostridium saccharolyticum WM1 chromosome, complete genomeFibronectin type III domain protein4e-0654.3
NC_015067:2136048:2166573216657321689692397Bifidobacterium longum subsp. longum JCM 1217, complete genomeglycoside hydrolase6e-0653.9
NC_011979:2969969:2969969296996929762836315Geobacter sp. FRC-32, complete genomecytochrome C family protein7e-0653.5
NC_009617:1085000:110107611010761101843768Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell wall binding repeat-containing protein8e-0653.5
NC_010674:3362071:337240633724063372723318Clostridium botulinum B str. Eklund 17B, complete genomecollagenolytic protease1e-0553.1