Pre_GI: BLASTP Hits

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Query: NC_010723:3133302:3133302 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 3133302, End: 3135161, Length: 1860

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012913:2189862:220225422022542203171918Aggregatibacter aphrophilus NJ8700, complete genomecholine kinase1e-44181
NC_009633:3933941:395477039547703955687918Alkaliphilus metalliredigens QYMF chromosome, complete genomecholine/ethanolamine kinase3e-49197
NC_009922:2556033:257972025797202580634915Alkaliphilus oremlandii OhILAs, complete genomeCholine/ethanolamine kinase8e-48192
NC_015320:1260344:128055412805541281288735Archaeoglobus veneficus SNP6 chromosome, complete genomeNucleotidyl transferase8e-1375.9
NC_006347:2154906:215618221561822156901720Bacteroides fragilis YCH46, complete genomeputative glucose-1-P-cytidylyltransferase2e-22107
NC_014328:4316008:431600843160084316943936Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative choline kinase4e-47190
NC_013173:133466:140636140636141307672Desulfomicrobium baculatum DSM 4028, complete genomeUDP-N-acetylglucosamine pyrophosphorylase related protein2e-0655.1
NC_016584:5625975:564571056457105646624915Desulfosporosinus orientis DSM 765 chromosome, complete genomecholine kinase2e-47191
NC_015589:2100175:210275721027572103671915Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeCholine/ethanolamine kinase1e-50201
NC_013592:2059138:207828920782892079014726Dickeya dadantii Ech586, complete genomeNucleotidyl transferase1e-0758.9
NC_013204:2826500:2850273285027328520601788Eggerthella lenta DSM 2243, complete genomeCholine/ethanolamine kinase2e-28127
NC_013204:2371499:2373994237399423757631770Eggerthella lenta DSM 2243, complete genomeaminoglycoside phosphotransferase3e-29130
NC_015738:978794:1024785102478510265751791Eggerthella sp. YY7918, complete genomehypothetical protein4e-23110
NC_012780:430653:4459614459614477301770Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequencecholine kinase / choline-phosphate cytidylyltransferase1e-26122
NC_003454:1889529:1893543189354318951471605Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeCholine kinase2e-67257
NC_019964:1031660:103501710350171035742726Halovivax ruber XH-70, complete genomeputative sugar nucleotidyltransferase6e-1376.6
NC_014122:393856:4116714116714129391269Methanocaldococcus infernus ME chromosome, complete genomeCDP-alcohol phosphatidyltransferase2e-0655.1
NC_009051:1588060:160615416061541606966813Methanoculleus marisnigri JR1, complete genomeputative nucleotide sugar-1-phosphate transferase1e-1482
NC_015676:1736375:1775802177580217770041203Methanosalsum zhilinae DSM 4017 chromosome, complete genomeNucleotidyl transferase6e-0859.7
NC_015676:1736375:1771424177142417726321209Methanosalsum zhilinae DSM 4017 chromosome, complete genomeNucleotidyl transferase1e-0862
NC_007681:1455425:1465432146543214667271296Methanosphaera stadtmanae DSM 3091, complete genomepredicted nucleoside-diphosphate-sugar pyrophosphorylase2e-0655.1
NC_019974:2889375:291015929101592910893735Natronococcus occultus SP4, complete genomedTDP-glucose pyrophosphorylase2e-0654.3
NC_014363:645397:6721736721736739871815Olsenella uli DSM 7084 chromosome, complete genomeCholine/ethanolamine kinase2e-30134
NC_009615:1627961:1642969164296916447801812Parabacteroides distasonis ATCC 8503 chromosome, complete genomehemolysin erythrocyte lysis protein 21e-0655.8
NC_015311:24071:3866138661404451785Prevotella denticola F0289 chromosome, complete genomeclass I/II aminotransferase6e-0653.1
NC_014033:103020:1109691109691127861818Prevotella ruminicola 23 chromosome, complete genomehemolysin erythrocyte lysis protein 22e-0861.6
NC_007925:4294472:430495843049584305722765Rhodopseudomonas palustris BisB18, complete genomeNucleotidyl transferase8e-0859.3
NC_015977:189101:1907961907961926011806Roseburia hominis A2-183 chromosome, complete genomeaminotransferase6e-1066.2
NC_014833:1539678:1537649153764915396882040Ruminococcus albus 7 chromosome, complete genomephosphoenolpyruvate phosphomutase5e-1066.6
NC_013165:1407000:1426686142668614284971812Slackia heliotrinireducens DSM 20476, complete genomeCTP:phosphocholine cytidylyltransferase6e-21102
NC_015732:1507473:1507473150747315093051833Spirochaeta caldaria DSM 7334 chromosome, complete genome2-aminoethylphosphonate aminotransferase1e-22108
NC_014484:1690272:1699910169991017017691860Spirochaeta thermophila DSM 6192 chromosome, complete genomeaminotransferase, class V4e-25116
NC_018870:705900:7148797148797159071029Thermacetogenium phaeum DSM 12270 chromosome, complete genomecholine/ethanolamine kinase4e-25116
NC_014152:1:269532695327909957Thermincola sp. JR, complete genomeCholine/ethanolamine kinase5e-36153
NC_015500:311845:3161493161493179931845Treponema brennaborense DSM 12168 chromosome, complete genome2-aminoethylphosphonate aminotransferase5e-21103
NC_016844:107382:1203531203531220441692Treponema pallidum subsp. pallidum DAL-1 chromosome, completeputative bifunctional choline-phosphate cytidylyltransferase/choline kinase2e-24114
NC_010741:107370:1203411203411219181578Treponema pallidum subsp. pallidum SS14, complete genomeprotein LicC2e-24114
NC_021508:107384:1203551203551219321578Treponema pallidum subsp. pallidum SS14, complete genomebifunctional choline-phosphatase cytidyltransferase/choline kinase2e-24114
NC_017268:107387:1203581203581221691812Treponema pallidum subsp. pallidum str. Chicago chromosome,LicC protein1e-24114
NC_000919:107373:1203441203441219211578Treponema pallidum subsp. pallidum str. Nichols, complete genomelicC protein (licC)2e-24114