Pre_GI: BLASTP Hits

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Query: NC_010723:298954:317452 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 317452, End: 317709, Length: 258

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:311378:323994323994324251258Clostridium botulinum B str. Eklund 17B, complete genomeGIY-YIG domain protein3e-38157
NC_020291:270234:286915286915287154240Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative endonuclease containing a URI domain6e-28122
NC_009922:315870:335768335768336031264Alkaliphilus oremlandii OhILAs, complete genomeExcinuclease ABC C subunit domain protein4e-22103
NC_014328:180482:197612197612197863252Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein6e-22102
NC_013158:2303000:230516023051602305435276Halorhabdus utahensis DSM 12940, complete genomeExcinuclease ABC C subunit domain protein1e-2098.6
NC_012673:1650139:165098016509801651258279Exiguobacterium sp. AT1b, complete genomeExcinuclease ABC C subunit domain protein1e-2098.2
NC_012121:113912:132481132481132741261Staphylococcus carnosus subsp. carnosus TM300, complete genomeputative nuclease2e-1994.4
NC_004193:35698:435844358443844261Oceanobacillus iheyensis HTE831, complete genomehypothetical protein3e-1993.6
NC_013204:2305140:230806023080602308425366Eggerthella lenta DSM 2243, complete genomeExcinuclease ABC C subunit domain protein2e-1891.3
NC_011900:1451545:145378214537821454081300Streptococcus pneumoniae ATCC 700669, complete genomehypothetical protein1e-1788.2
NC_007759:1028977:107141610714161071679264Syntrophus aciditrophicus SB, complete genomepredicted endonuclease containing a URI domain5e-1786.3
NC_017208:1:394893948939752264Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-1785.5
NC_016884:157894:178155178155178418264Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeExcinuclease ABC C subunit domain-containing protein5e-1476.3
NC_016616:2112211:214716621471662147462297Dechlorosoma suillum PS chromosome, complete genomeputative endonuclease containing a URI domain8e-1475.5
NC_009379:435404:437122437122437364243Polynucleobacter sp. QLW-P1DMWA-1, complete genomeExcinuclease ABC, C subunit domain protein4e-1373.6
NC_012796:4075583:412763641276364127914279Desulfovibrio magneticus RS-1, complete genomehypothetical protein6e-1372.8
NC_014221:2188250:219222621922262192504279Truepera radiovictrix DSM 17093 chromosome, complete genomeExcinuclease ABC C subunit domain protein9e-1372
NC_010681:1234500:125690612569061257235330Burkholderia phytofirmans PsJN chromosome 1, complete sequenceExcinuclease ABC C subunit domain protein6e-1269.7
NC_016945:666000:685453685453685758306Vibrio cholerae IEC224 chromosome II, complete sequenceendonuclease containing a URI domain6e-1269.3
NC_018607:1251357:126050312605031260778276Brachyspira pilosicoli B2904 chromosome, complete genomeendonuclease containing a URI domain2e-1167.8
NC_014330:2520906:252882225288222529157336Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative excinuclease ABC subunit C4e-1166.6
NC_018604:1489567:149822214982221498557336Brachyspira pilosicoli WesB complete genomeputative excinuclease ABC subunit C4e-1166.6
NC_016628:373815:378606378606378896291Vibrio furnissii NCTC 11218 chromosome 2, complete sequencehypothetical protein5e-1166.2
NC_019908:700000:711532711532711867336Brachyspira pilosicoli P43/6/78 chromosome, complete genomeexcinuclease ABC subunit C5e-1166.2
NC_012796:2090000:209527920952792095539261Desulfovibrio magneticus RS-1, complete genomehypothetical protein2e-1064.7
NC_012108:481657:500637500637500957321Desulfobacterium autotrophicum HRM2, complete genomehypothetical protein4e-1063.2
NC_008260:2142311:215805421580542158443390Alcanivorax borkumensis SK2, complete genomehypothetical protein7e-1062.8
NC_003112:364869:368832368832369107276Neisseria meningitidis MC58, complete genomehypothetical protein4e-0960.5
NC_008767:1829500:184480418448041845079276Neisseria meningitidis FAM18, complete genomehypothetical protein4e-0960.5
NC_017513:1845069:185729818572981857573276Neisseria meningitidis G2136 chromosome, complete genomeGIY-YIG catalytic domain-containing protein4e-0960.5
NC_017514:1885154:189861518986151898890276Neisseria meningitidis M01-240149 chromosome, complete genomeGIY-YIG catalytic domain-containing protein4e-0960.5
NC_017515:372487:375336375336375611276Neisseria meningitidis M04-240196 chromosome, complete genomeGIY-YIG catalytic domain-containing protein4e-0960.5
NC_017516:364404:368367368367368642276Neisseria meningitidis H44/76 chromosome, complete genomeGIY-YIG catalytic domain-containing protein4e-0960.5
NC_017518:2041282:205284420528442053119276Neisseria meningitidis NZ-05/33 chromosome, complete genomeGIY-YIG catalytic domain-containing protein4e-0960.5
NC_007925:4060635:407708040770804077385306Rhodopseudomonas palustris BisB18, complete genomeExcinuclease ABC, C subunit-like3e-0960.5
NC_005773:1333863:133713713371371337439303Pseudomonas syringae pv. phaseolicola 1448A, complete genomeendo/excinuclease domain protein3e-0960.5
NC_011035:1564821:157964415796441579919276Neisseria gonorrhoeae NCCP11945 chromosome, complete genomehypothetical protein6e-0959.7
NC_017511:1467090:148248014824801482755276Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein6e-0959.7
NC_002946:1556000:157036915703691570644276Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein5e-0959.7
NC_013016:1801000:181602618160261816301276Neisseria meningitidis alpha14 chromosome, complete genomeputative endonuclease1e-0858.9
NC_010120:1814592:182957318295731829848276Neisseria meningitidis 053442, complete genomeputative endonuclease1e-0858.9
NC_017512:1824966:183987918398791840154276Neisseria meningitidis WUE 2594, complete genomehypothetical protein1e-0858.5
NC_003116:2063500:207571320757132075988276Neisseria meningitidis Z2491, complete genomehypothetical protein1e-0858.5
NC_005125:760721:784486784486784842357Gloeobacter violaceus PCC 7421, complete genomehypothetical protein1e-0858.2
NC_020156:2750000:275750327575032757856354Nonlabens dokdonensis DSW-6, complete genomeprotein containing N-terminal domain of the UvrABC system protein C4e-0857
NC_015555:49842:6212562125654913367Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete23S ribosomal RNA4e-0856.6
NC_015555:327562:3747443747443781113368Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete23S ribosomal RNA7e-0855.8
NC_015555:49842:8135181351847183368Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete23S ribosomal RNA7e-0855.8
NC_014934:2519999:253818625381862538434249Cellulophaga algicola DSM 14237 chromosome, complete genomeexcinuclease abc c subunit domain protein7e-0855.8
NC_009727:1177390:119093911909391191226288Coxiella burnetii Dugway 7E9-12, complete genomeGIY-YIG catalytic domain protein8e-0752.4
NC_014934:2519999:253773925377392537987249Cellulophaga algicola DSM 14237 chromosome, complete genomeexcinuclease abc c subunit domain protein8e-0752.4
NC_014410:51711:8126881268846253358Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,23S ribosomal RNA3e-0650.4
NC_010831:2078329:210387121038712104125255Chlorobium phaeobacteroides BS1, complete genomeExcinuclease ABC C subunit domain protein4e-0650.4
NC_013171:1364464:137480013748001375090291Anaerococcus prevotii DSM 20548, complete genomeExcinuclease ABC C subunit domain protein4e-0650.1