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Query: NC_010723:298954:316620 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 316620, End: 317063, Length: 444

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016641:438500:445079445079445504426Paenibacillus terrae HPL-003 chromosome, complete genomeMarR family transcriptional regulator4e-0857
NC_011837:56000:757257572576159435Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-0857
NC_009706:56000:757257572576159435Clostridium kluyveri DSM 555 chromosome, complete genometranscriptional regulator4e-0857
NC_014479:2505823:251606925160692516494426Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeMarR family transcriptional regulator5e-0856.6
NC_013406:3400114:340848834084883408913426Paenibacillus sp. Y412MC10 chromosome, complete genomeMarR family transcriptional regulator7e-0856.2
NC_010003:1444623:144635314463531446850498Petrotoga mobilis SJ95, complete genometranscriptional regulator, MarR family6e-0856.2
NC_007296:1073784:108834310883431088768426Streptococcus pyogenes MGAS6180, complete genometranscriptional regulator, MarR family3e-0753.9
NC_009921:6447151:646546464654646466015552Frankia sp. EAN1pec, complete genometranscriptional regulator, MarR family5e-0753.1
NC_013947:3406000:341245434124543412918465Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, MarR family1e-0652.4
NC_012108:1694817:170877717087771709223447Desulfobacterium autotrophicum HRM2, complete genomeputative MarR family protein1e-0651.6
NC_014727:889132:891398891398891880483Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,transcriptional regulator6e-0649.7