Pre_GI: BLASTP Hits

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Query: NC_010723:2735196:2750889 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2750889, End: 2752190, Length: 1302

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:2946576294657629478801305Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein0785
NC_015425:906969:9084169084169097351320Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-63244
NC_012563:2979147:2998706299870629999051200Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-61236
NC_009697:2680607:2697530269753026987291200Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein8e-61234
NC_003366:1901898:1919598191959819208841287Clostridium perfringens str. 13, complete genomeprobable lipoprotein2e-59230
NC_008261:2117207:2134911213491121361971287Clostridium perfringens ATCC 13124, complete genomehypothetical protein3e-59229
NC_008262:1795914:1808961180896118102471287Clostridium perfringens SM101, complete genomehypothetical protein2e-58226
NC_008593:841291:8427408427408440711332Clostridium novyi NT, complete genomePredicted membrane protein4e-57222
NC_010718:3039434:3043822304382230456601839Natranaerobius thermophilus JW/NM-WN-LF, complete genomeGlucose/sorbosone dehydrogenase-like protein4e-21102