Pre_GI: BLASTP Hits

Some Help

Query: NC_010723:2735196:2748496 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2748496, End: 2750160, Length: 1665

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:2944183294418329458471665Clostridium botulinum B str. Eklund 17B, complete genomeradical SAM domain protein01009
NC_008261:2117207:2132583213258321342621680Clostridium perfringens ATCC 13124, complete genomeradical SAM domain protein0671
NC_003366:1901898:1917270191727019189491680Clostridium perfringens str. 13, complete genomeMg-protoporphyrin IX monomethyl ester oxidative cyclase0669
NC_008262:1795914:1806633180663318083121680Clostridium perfringens SM101, complete genomeradical SAM domain protein0664
NC_015425:906969:9111619111619128671707Clostridium botulinum BKT015925 chromosome, complete genomeputative B12-binding Fe-S oxidoreductase0648
NC_008593:841291:8454518454518472231773Clostridium novyi NT, complete genomemagnesium-protoporphyrin IX monomethyl ester oxidative cyclase0645
NC_009697:2680607:2694388269438826960671680Clostridium botulinum A str. ATCC 19397 chromosome, completeB12-binding Fe-S oxidoreductase0639
NC_012563:2979147:2995558299555829972431686Clostridium botulinum A2 str. Kyoto, complete genomeputative B12-binding Fe-S oxidoreductase0635
NC_009922:1917271:1933111193311119349071797Alkaliphilus oremlandii OhILAs, complete genomeRadical SAM domain protein7e-116417
NC_013315:796313:7975837975837993371755Clostridium difficile CD196 chromosome, complete genomeadenosylcobamide-dependent radical SAM protein9e-110397
NC_017179:805867:8071378071378088911755Clostridium difficile BI1, complete genomeadenosylcobamide-dependent radical SAM protein9e-110397
NC_018664:985689:9878449878449896281785Clostridium acidurici 9a chromosome, complete genomecobalamin B12-binding/radical SAM domain-containing protein1e-107390
NC_014614:1309203:1309203130920313110081806Clostridium sticklandii, complete genomeputative adenosylcobamide-dependent radical SAM superfamily protein5e-95348
NC_017192:1841987:1872735187273518742461512Arcobacter sp. L, complete genomehypothetical protein2e-64247
NC_011567:2405000:2414483241448324159881506Anoxybacillus flavithermus WK1, complete genomeRadical SAM superfamily enzyme6e-34145
NC_015740:2966184:2976452297645229776781227Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completesam domain-containing protein1e-20101
NC_009953:3316782:3332718333271833345951878Salinispora arenicola CNS-205 chromosome, complete genomeradical SAM domain-containing protein5e-2099.8
NC_009050:811358:8281058281058301142010Rhodobacter sphaeroides ATCC 17029 chromosome 2, complete sequenceRadical SAM domain protein1e-1998.6
NC_013849:19404:3305733057344541398Ferroglobus placidus DSM 10642 chromosome, complete genomeRadical SAM domain protein2e-1997.8
NC_009455:273519:2907222907222922061485Dehalococcoides sp. BAV1 chromosome, complete genomeradical SAM domain-containing protein6e-1996.3
NC_007356:51080:7733677336788201485Dehalococcoides sp. CBDB1, complete genomeradical SAM/B12 binding domain protein1e-1895.1
NC_015437:1685824:1693465169346516952371773Selenomonas sputigena ATCC 35185 chromosome, complete genomeRadical SAM domain protein2e-1894.7
NC_010572:1081236:1084540108454010863931854Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative methyltransferase1e-1792
NC_014844:762794:7785687785687800221455Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeRadical SAM domain-containing protein5e-1789.7
NC_013552:68003:9497094970964541485Dehalococcoides sp. VS, complete genomeradical SAM/B12 binding domain protein3e-1687
NC_009033:653462:6723696723696737931425Staphylothermus marinus F1, complete genomeRadical SAM domain protein8e-1685.9
NC_007955:1664998:1681943168194316834061464Methanococcoides burtonii DSM 6242, complete genomeFe-S protein, radical SAM family2e-1584.7
NC_014166:2959688:2960989296098929624491461Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeradical SAM domain-containing protein3e-1583.6
NC_020304:129321:1511821511821526781497Desulfocapsa sulfexigens DSM 10523, complete genomeFe-S oxidoreductase1e-1482
NC_014314:1:1298112981144441464Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeradical SAM domain-containing protein2e-1480.9
NC_008639:2968000:2968727296872729705531827Chlorobium phaeobacteroides DSM 266, complete genomeMagnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase7e-1479.3
NC_015388:719669:7410057410057428791875Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeRadical SAM domain protein1e-1378.6
NC_015682:205900:2467522467522481191368Thermodesulfobacterium sp. OPB45 chromosome, complete genomeRadical SAM domain-containing protein2e-1378.2
NC_015416:1571451:1573507157350715752581752Methanosaeta concilii GP-6 chromosome, complete genomeB12 binding domain/radical SAM domain fusion protein2e-1377.8
NC_010506:2441944:2457737245773724592571521Shewanella woodyi ATCC 51908, complete genomeRadical SAM domain protein2e-1377.8
NC_008609:2787274:2792682279268227947062025Pelobacter propionicus DSM 2379, complete genomeMagnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase2e-1377.8
NC_015416:621513:6369866369866384461461Methanosaeta concilii GP-6 chromosome, complete genomeradical SAM domain-containing protein6e-1376.3
NC_011729:3955310:3971055397105539724911437Cyanothece sp. PCC 7424 chromosome, complete genomehopanoid biosynthesis associated radical SAM protein HpnJ2e-1274.7
NC_007643:889755:8955118955118969651455Rhodospirillum rubrum ATCC 11170, complete genomeFe-S oxidoreductase3e-1273.9
NC_011060:459615:5010805010805029091830Pelodictyon phaeoclathratiforme BU-1, complete genomeRadical SAM domain protein3e-1273.9
NC_019977:2141677:2156291215629121573971107Methanomethylovorans hollandica DSM 15978, complete genomeB12-binding domain/radical SAM domain protein, MJ_1487 family3e-1273.6
NC_010814:794211:8177818177818192501470Geobacter lovleyi SZ, complete genomeRadical SAM domain protein1e-1172
NC_009464:2523092:2544684254468425461291446Uncultured methanogenic archaeon RC-I, complete genomepredicted Fe-S cluster-binding oxidoreductase1e-1172
NC_007954:1324062:1343878134387813455781701Shewanella denitrificans OS217, complete genomeRadical SAM1e-1171.6
NC_020409:2856481:2885479288547928874761998Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completehypothetical protein4e-1170.1
NC_011832:619874:6379966379966394651470Candidatus Methanosphaerula palustris E1-9c, complete genomeRadical SAM domain protein4e-1170.1
NC_008312:7546500:7570338757033875717681431Trichodesmium erythraeum IMS101, complete genomeRadical SAM5e-1169.7
NC_007955:1523500:1545251154525115463571107Methanococcoides burtonii DSM 6242, complete genomeFe-S protein, radical SAM family5e-1169.7
NC_008609:3672653:3680168368016836839203753Pelobacter propionicus DSM 2379, complete genomeglycosyl transferase, family 27e-1169.3
NC_008278:296526:3192483192483208161569Frankia alni ACN14a, complete genomeputative F-S oxidoreductase; putative methyltransferase.3e-1067.4
NC_009615:1553556:1564365156436515658221458Parabacteroides distasonis ATCC 8503 chromosome, complete genomeFe-S oxidoreductase4e-1067
NC_007907:3230513:3242134324213432435191386Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-1066.6
NC_014658:743453:7607717607717620601290Methanothermus fervidus DSM 2088 chromosome, complete genomeradical sam domain protein9e-1065.9
NC_000961:1481685:1494072149407214953581287Pyrococcus horikoshii OT3, complete genomehypothetical protein1e-0965.1
NC_008576:2011959:2021071202107120225431473Magnetococcus sp. MC-1, complete genomeRadical SAM domain protein2e-0964.3
NC_014960:1735786:1760110176011017617441635Anaerolinea thermophila UNI-1, complete genomehypothetical protein2e-0964.3
NC_018876:2151226:2170078217007821710791002Methanolobus psychrophilus R15 chromosome, complete genomehypothetical protein3e-0963.9
NC_011060:244949:2632772632772660662790Pelodictyon phaeoclathratiforme BU-1, complete genomeRadical SAM domain protein6e-0963.2
NC_013440:1698047:1713733171373317153551623Haliangium ochraceum DSM 14365, complete genomeRadical SAM domain protein7e-0962.8
NC_014507:1403000:1418340141834014198121473Methanoplanus petrolearius DSM 11571 chromosome, complete genomeRadical SAM domain-containing protein1e-0862
NC_011978:493800:4986494986494997791131Thermotoga neapolitana DSM 4359, complete genomehypothetical protein1e-0862
NC_013216:3376186:3394582339458233962401659Desulfotomaculum acetoxidans DSM 771, complete genomeRadical SAM domain protein1e-0861.6
NC_010831:2078329:209216920921692093035867Chlorobium phaeobacteroides BS1, complete genomecobalamin B12-binding domain protein3e-0860.5
NC_011830:4234392:4244459424445942458081350Desulfitobacterium hafniense DCB-2, complete genomeRadical SAM domain protein4e-0860.1
NC_020453:6821500:6843477684347768450151539Agromonas oligotrophica S58 DNA, complete genomeFe-S oxidoreductase6e-0859.7
NC_018645:4104302:4114112411411241155211410Desulfobacula toluolica Tol2, complete genomeradical SAM domain-containing protein1e-0758.5
NC_002932:1851070:1855813185581318574531641Chlorobium tepidum TLS, complete genomemagnesium-protoporphyrin IX monomethyl ester oxidative cyclase, 66 kDa subunit1e-0758.5
NC_008609:3672653:3684329368432936859961668Pelobacter propionicus DSM 2379, complete genomeRadical SAM domain protein1e-0758.5
NC_009051:2365711:2375357237535723768291473Methanoculleus marisnigri JR1, complete genomeRadical SAM domain protein2e-0757.8
NC_020418:3022891:3024237302423730256311395Morganella morganii subsp. morganii KT, complete genomehypothetical protein2e-0757.8
NC_008609:3732192:3741104374110437425611458Pelobacter propionicus DSM 2379, complete genomeMagnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase4e-0756.6
NC_014623:659422:6682526682526698741623Stigmatella aurantiaca DW4/3-1 chromosome, complete genomehypothetical protein8e-0755.8
NC_018645:4490957:4504623450462345059931371Desulfobacula toluolica Tol2, complete genomeradical SAM domain-containing protein1e-0655.5
NC_011653:1339868:1349215134921513503451131Thermosipho africanus TCF52B, complete genomeFe-S oxidoreductase family protein1e-0655.5
NC_018645:3029785:3049486304948630509461461Desulfobacula toluolica Tol2, complete genomecobalamin-binding, radical SAM protein2e-0654.7
NC_020195:330000:3481303481303494581329Blattabacterium sp. (Blatta orientalis) str. Tarazona, completeputative 2-methylthioadenine synthetase2e-0654.7
NC_012797:1:1133711337127821446Desulfovibrio magneticus RS-1 plasmid pDMC1, complete sequencehypothetical protein2e-0654.3
NC_004557:2677155:2694814269481426961331320Clostridium tetani E88, complete genomecoproporphyrinogen III oxidase3e-0654.3
NC_002976:1361364:138146813814681382421954Staphylococcus epidermidis RP62A, complete genomehypothetical protein5e-0653.5
NC_004461:1465397:148550114855011486454954Staphylococcus epidermidis ATCC 12228, complete genomehypothetical protein5e-0653.5
NC_015562:1299648:1321696132169613228591164Methanotorris igneus Kol 5 chromosome, complete genomeRadical SAM domain-containing protein4e-0653.5
NC_013525:1221604:1262290126229012637081419Thermobaculum terrenum ATCC BAA-798 chromosome 1, complete genomeRadical SAM domain protein6e-0652.8
NC_007168:1167454:116745411674541168413960Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein9e-0652.4