Pre_GI: BLASTP Hits

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Query: NC_010723:2735196:2746002 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2746002, End: 2747936, Length: 1935

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:2941689294168929436231935Clostridium botulinum B str. Eklund 17B, complete genomeV-type ATPase, I subunit01189
NC_008261:2117207:2130044213004421319931950Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, I subunit4e-152538
NC_008262:1795914:1804097180409718060431947Clostridium perfringens SM101, complete genomeV-type ATPase, I subunit7e-152537
NC_003366:1901898:1914734191473419166801947Clostridium perfringens str. 13, complete genomeATP synthase subunit I5e-151535
NC_012563:2979147:2992960299296029949211962Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, I subunit2e-118426
NC_009697:2680607:2691808269180826937691962Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit I5e-117422
NC_015425:906969:9133929133929153561965Clostridium botulinum BKT015925 chromosome, complete genomeV-type sodium ATP synthase subunit I6e-115415
NC_008593:841291:8477828477828497371956Clostridium novyi NT, complete genomeV-type sodium ATP synthase subunit I2e-108393
NC_013192:815854:8225828225828245551974Leptotrichia buccalis DSM 1135, complete genomeSodium-transporting two-sector ATPase3e-99362
NC_009785:130252:1339321339321358871956Streptococcus gordonii str. Challis substr. CH1, complete genomev-type sodium ATP synthase, chain I6e-82305
NC_017179:3222015:3233734323373432356591926Clostridium difficile BI1, complete genomeV-type sodium ATP synthase subunit I1e-72275
NC_013315:3214063:3225782322578232277071926Clostridium difficile CD196 chromosome, complete genomeV-type sodium ATP synthase subunit I1e-72275
NC_013921:2375900:2389990238999023919631974Thermoanaerobacter italicus Ab9 chromosome, complete genomeV-type ATPase 116 kDa subunit3e-70266
NC_010321:2319820:2332550233255023345231974Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeH(+)-transporting two-sector ATPase5e-70266
NC_014964:2301835:2314565231456523165381974Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeV-type ATPase 116 kDa subunit5e-70266
NC_014209:2257316:2271408227140822733811974Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,V-type ATPase 116 kDa subunit5e-70266
NC_010320:2397395:2411842241184224137731932Thermoanaerobacter sp. X514 chromosome, complete genomeH(+)-transporting two-sector ATPase7e-70265
NC_014538:2396559:2411006241100624129371932Thermoanaerobacter sp. X513 chromosome, complete genomeV-type ATPase 116 kDa subunit7e-70265
NC_003413:181525:1861071861071880981992Pyrococcus furiosus DSM 3638, complete genomeATP synthase subunit I1e-46188
NC_015474:723553:7477557477557497341980Pyrococcus sp. NA2 chromosome, complete genomeV-type ATP synthase subunit I5e-46186
NC_000868:1730820:1744954174495417469331980Pyrococcus abyssi GE5, complete genomeATP synthase subunit I3e-43177
NC_005791:1028500:1031753103175310338132061Methanococcus maripaludis S2, complete genomeATP synthase subunit I9e-42172
NC_009135:494949:5073525073525094212070Methanococcus maripaludis C5, complete genomeV-type ATPase, 116 kDa subunit2e-41171
NC_015847:1119666:1125867112586711279272061Methanococcus maripaludis XI chromosome, complete genomeV-type ATP synthase subunit I3e-41170
NC_009637:302881:3089383089383109982061Methanococcus maripaludis C7 chromosome, complete genomeV-type ATP synthase subunit I5e-41169
NC_009975:1500978:1512794151279415148542061Methanococcus maripaludis C6, complete genomeH(+)-transporting two-sector ATPase9e-41169
NC_015562:627000:6315636315636336052043Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATPase 116 kDa subunit7e-39162
NC_013407:1610221:1619996161999616220622067Methanocaldococcus vulcanius M7, complete genomeV-type ATPase 116 kDa subunit2e-38161
NC_000909:201000:2120612120612141482088Methanocaldococcus jannaschii DSM 2661, complete genomeATP synthase subunit I2e-38161
NC_013156:431795:4371474371474391622016Methanocaldococcus fervens AG86, complete genomeV-type ATPase 116 kDa subunit4e-37156
NC_012883:1603744:1617564161756416195491986Thermococcus sibiricus MM 739, complete genomeA1A0 ATP synthase, subunit a4e-37156
NC_015574:2057602:2064237206423720662432007Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATPase 116 kDa subunit5e-36153
NC_014222:186876:1912651912651933072043Methanococcus voltae A3 chromosome, complete genomeV-type ATPase 116 kDa subunit3e-35150
NC_009634:411599:4180174180174200862070Methanococcus vannielii SB chromosome, complete genomeV-type ATP synthase subunit I4e-35150
NC_015216:405657:4101194101194121041986Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATPase 116 kDa subunit5e-34146
NC_014122:393856:4010584010584030732016Methanocaldococcus infernus ME chromosome, complete genomeV-type ATPase 116 kDa subunit9e-32139
NC_013926:1205443:1215085121508512172232139Aciduliprofundum boonei T469 chromosome, complete genomeV-type ATPase 116 kDa subunit6e-32139
NC_019977:828427:8474308474308493761947Methanomethylovorans hollandica DSM 15978, complete genomearchaeal/vacuolar-type H+-ATPase subunit I5e-30133
NC_018876:2380018:2399727239972724016611935Methanolobus psychrophilus R15 chromosome, complete genomeV-type ATP synthase subunit I7e-30132
NC_013741:1390823:1394820139482013969132094Archaeoglobus profundus DSM 5631, complete genomeV-type ATPase 116 kDa subunit9e-29129
NC_015636:1477221:1490429149042914925072079Methanothermococcus okinawensis IH1 chromosome, complete genomeV-type ATPase 116 kDa subunit2e-28128
NC_009635:61344:6606966069681112043Methanococcus aeolicus Nankai-3 chromosome, complete genomeV-type ATP synthase subunit I2e-28127
NC_015160:2295010:2313403231340323153011899Odoribacter splanchnicus DSM 20712 chromosome, complete genomeV-type ATPase 116 kDa subunit3e-22107
NC_016148:951446:9619189619189638341917Thermovirga lienii DSM 17291 chromosome, complete genomeV-type ATPase 116 kDa subunit6e-21103
NC_014315:1042556:1058905105890510607911887Nitrosococcus watsoni C-113 chromosome, complete genomeV-type ATPase 116 kDa subunit2e-20101
NC_014330:1113145:1137575113757511394341860Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative V-type ATP synthase subunit I1e-1998.6
NC_019908:2068631:2077896207789620797551860Brachyspira pilosicoli P43/6/78 chromosome, complete genomeV-type ATP synthase subunit I1e-1998.6
NC_018012:1935500:1936615193661519385101896Thiocystis violascens DSM 198 chromosome, complete genomearchaeal/vacuolar-type H+-ATPase subunit I1e-1998.6
NC_018604:2579000:2618923261892326207821860Brachyspira pilosicoli WesB complete genomeputative V-type ATP synthase subunit I2e-1997.8
NC_002689:46243:5675556755586861932Thermoplasma volcanium GSS1, complete genomeATP synthase subunit I4e-1997.1
NC_005877:509877:5144365144365163581923Picrophilus torridus DSM 9790, complete genomeATP synthase subunit I1e-1895.1
NC_018607:290500:3021943021943040441851Brachyspira pilosicoli B2904 chromosome, complete genomeV-type ATP synthase subunit I2e-1894.4
NC_007484:2392739:2396096239609623979821887Nitrosococcus oceani ATCC 19707, complete genomeV-type ATPase, 116 kDa subunit6e-1893.2
NC_012225:2198987:2208546220854622104141869Brachyspira hyodysenteriae WA1, complete genomeputative V-type ATP synthase subunit I5e-1790.1
NC_017243:3141500:3148412314841231502111800Brachyspira intermedia PWS/A chromosome, complete genomeV-type ATP synthase subunit I1e-1689
NC_005213:202400:3573663573663587541389Nanoarchaeum equitans Kin4-M, complete genomehypothetical protein2e-1584.7
NC_005213:295994:3573663573663587541389Nanoarchaeum equitans Kin4-M, complete genomehypothetical protein2e-1584.7
NC_007681:1300068:1311770131177013137671998Methanosphaera stadtmanae DSM 3091, complete genomeAhaI2e-1481.6
NC_014614:2434017:2448062244806224500411980Clostridium sticklandii, complete genomeputative V-type sodium ATP synthase subunit I2e-1377.8
NC_012622:1421098:1434908143490814370132106Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeV-type ATP synthase subunit I3e-1377.4
NC_012589:1531725:1545535154553515476402106Sulfolobus islandicus L.S.2.15, complete genomeV-type ATPase 116 kDa subunit3e-1377.4
NC_012623:1119192:1121076112107611231812106Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeV-type ATP synthase subunit I1e-1275.5
NC_017275:1486526:1500335150033515024402106Sulfolobus islandicus HVE10/4 chromosome, complete genomeV-type ATPase 116 kDa subunit1e-1275.5
NC_012588:1443753:1457563145756314596682106Sulfolobus islandicus M.14.25 chromosome, complete genomeV-type ATP synthase subunit I1e-1275.5
NC_012632:1568170:1581980158198015840852106Sulfolobus islandicus M.16.27 chromosome, complete genomeV-type ATP synthase subunit I1e-1275.5
NC_012726:1431745:1445555144555514476602106Sulfolobus islandicus M.16.4 chromosome, complete genomeV-type ATP synthase subunit I1e-1275.5
NC_017276:1335474:1349284134928413513892106Sulfolobus islandicus REY15A chromosome, complete genomeV-type ATPase 116 kDa subunit1e-1275.1
NC_019791:1189908:1205010120501012070552046Caldisphaera lagunensis DSM 15908 chromosome, complete genomearchaeal/vacuolar-type H+-ATPase subunit I2e-1275.1
NC_002754:491695:4934054934054955102106Sulfolobus solfataricus P2, complete genomeATP synthase subunit I3e-1067.8
NC_003106:1435295:1436999143699914391042106Sulfolobus tokodaii str. 7, complete genomeATP synthase subunit I3e-1067.4
NC_009440:1857589:1860823186082318629402118Metallosphaera sedula DSM 5348 chromosome, complete genomeV-type ATP synthase subunit I8e-0962.8
NC_015518:1052701:1066438106643810686002163Acidianus hospitalis W1 chromosome, complete genomeV-type ATPase 116 kDa subunit4e-0860.5
NC_015435:310406:3242203242203263132094Metallosphaera cuprina Ar-4 chromosome, complete genomeV-type ATP synthase subunit I2e-0758.2