Pre_GI: BLASTP Hits

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Query: NC_010723:2735196:2745503 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2745503, End: 2745988, Length: 486

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:294119029411902941675486Clostridium botulinum B str. Eklund 17B, complete genomeV-type ATPase, K subunit2e-63241
NC_008262:1795914:180354318035431804037495Clostridium perfringens SM101, complete genomeV-type ATPase, K subunit2e-44177
NC_008261:2117207:212949521294952129989495Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, K subunit8e-44175
NC_003366:1901898:191418519141851914679495Clostridium perfringens str. 13, complete genomeATP synthase subunit K8e-44175
NC_009697:2680607:269131926913192691795477Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit K4e-32137
NC_012563:2979147:299247129924712992947477Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, K subunit1e-31135
NC_013192:815854:824622824622825095474Leptotrichia buccalis DSM 1135, complete genomeH+transporting two-sector ATPase C subunit1e-29129
NC_009785:130252:136020136020136499480Streptococcus gordonii str. Challis substr. CH1, complete genomev-type sodium ATP synthase, chain K2e-28125
NC_008593:841291:849827849827850327501Clostridium novyi NT, complete genomeV-type sodium ATP synthase subunit K4e-23107
NC_015425:906969:915445915445915945501Clostridium botulinum BKT015925 chromosome, complete genomeV-type ATPase, K subunit5e-22103
NC_017179:3222015:323324032332403233731492Clostridium difficile BI1, complete genomeV-type ATP synthase subunit K3e-2097.4
NC_013315:3214063:322528832252883225779492Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit K3e-2097.4
NC_014538:2396559:241048324104832410965483Thermoanaerobacter sp. X513 chromosome, complete genomeH+transporting two-sector ATPase subunit C2e-1891.3
NC_014964:2301835:231408223140822314564483Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeH+transporting two-sector ATPase subunit C4e-1890.5
NC_014209:2257316:227092522709252271407483Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,H+transporting two-sector ATPase C subunit4e-1890.5
NC_013921:2375900:238950723895072389989483Thermoanaerobacter italicus Ab9 chromosome, complete genomeH+transporting two-sector ATPase C subunit4e-1890.5
NC_010321:2319820:233206723320672332549483Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit K4e-1890.5
NC_010320:2397395:241131924113192411864546Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit K5e-1890.1
NC_014122:393856:403092403092403745654Methanocaldococcus infernus ME chromosome, complete genomeH(+)-transporting two-sector ATPase2e-0858.2
NC_015562:627000:633747633747634415669Methanotorris igneus Kol 5 chromosome, complete genomeATP synthase subunit c3e-0857.4
NC_015636:1477221:148960014896001490268669Methanothermococcus okinawensis IH1 chromosome, complete genomeATP synthase subunit c3e-0754.3
NC_009635:61344:681896818968860672Methanococcus aeolicus Nankai-3 chromosome, complete genomeV-type ATP synthase subunit K4e-0753.9
NC_013407:1610221:161921816192181619880663Methanocaldococcus vulcanius M7, complete genomeH(+)-transporting two-sector ATPase6e-0753.5
NC_013156:431795:439273439273439929657Methanocaldococcus fervens AG86, complete genomeH(+)-transporting two-sector ATPase7e-0753.1
NC_000909:201000:211295211295211957663Methanocaldococcus jannaschii DSM 2661, complete genomeATP synthase subunit K7e-0753.1
NC_009634:411599:420144420144420812669Methanococcus vannielii SB chromosome, complete genomeV-type ATP synthase subunit K7e-0753.1
NC_015847:1119666:112798011279801128648669Methanococcus maripaludis XI chromosome, complete genomeV-type ATP synthase subunit K7e-0753.1
NC_009975:1500978:151207215120721512740669Methanococcus maripaludis C6, complete genomeH+transporting two-sector ATPase C subunit7e-0753.1
NC_005791:1028500:103386610338661034534669Methanococcus maripaludis S2, complete genomeATP synthase subunit K7e-0753.1
NC_009135:494949:506628506628507296669Methanococcus maripaludis C5, complete genomeH+-transporting two-sector ATPase, C subunit7e-0753.1
NC_009637:302881:311052311052311720669Methanococcus maripaludis C7 chromosome, complete genomeV-type ATP synthase subunit K7e-0753.1
NC_014222:186876:193488193488194159672Methanococcus voltae A3 chromosome, complete genomeH(+)-transporting two-sector ATPase8e-0649.7