Pre_GI: BLASTP Hits

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Query: NC_010723:2735196:2743560 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2743560, End: 2743871, Length: 312

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:293924729392472939558312Clostridium botulinum B str. Eklund 17B, complete genomeATP synthase (F/14-kDa) subunit1e-52204
NC_003366:1901898:191223419122341912551318Clostridium perfringens str. 13, complete genomeV-type ATP synthase subunit F8e-45178
NC_008262:1795914:180159518015951801912318Clostridium perfringens SM101, complete genomeV-type ATPase, G subunit8e-45178
NC_008261:2117207:212754421275442127861318Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, G subunit8e-45178
NC_008593:841291:851968851968852276309Clostridium novyi NT, complete genomeATP synthase (F/14-kDa) subunit4e-42169
NC_012563:2979147:299051629905162990833318Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, G subunit1e-41168
NC_009697:2680607:268936426893642689672309Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit F1e-40165
NC_015425:906969:917572917572917880309Clostridium botulinum BKT015925 chromosome, complete genomeV-type ATPase, G subunit1e-39161
NC_013192:815854:826778826778827086309Leptotrichia buccalis DSM 1135, complete genomeVacuolar H+transporting two-sector ATPase F subunit2e-34144
NC_014209:2257316:226897822689782269307330Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,Vacuolar H+transporting two-sector ATPase F subunit2e-24110
NC_013921:2375900:238756023875602387889330Thermoanaerobacter italicus Ab9 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit3e-24110
NC_014377:2033781:205574720557472056076330Thermosediminibacter oceani DSM 16646 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit1e-23108
NC_014964:2301835:231213523121352312464330Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeVacuolar H+transporting two-sector ATPase subunit F1e-23108
NC_014538:2396559:240853624085362408865330Thermoanaerobacter sp. X513 chromosome, complete genomeVacuolar H+transporting two-sector ATPase subunit F1e-23108
NC_010320:2397395:240937224093722409707336Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit F1e-23108
NC_010321:2319820:233012023301202330455336Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit F1e-23108
NC_013315:3214063:322337132233713223694324Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit F3e-21100
NC_017179:3222015:323132332313233231640318Clostridium difficile BI1, complete genomeV-type ATP synthase subunit F3e-21100
NC_009785:130252:138111138111138431321Streptococcus gordonii str. Challis substr. CH1, complete genomeATP synthase (F/14-kDa) subunit5e-2096.3
NC_015574:2057602:206856420685642068884321Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATP synthase subunit F5e-1269.7
NC_016148:1021138:102214110221411022482342Thermovirga lienii DSM 17291 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit2e-0858.2
NC_013156:431795:441932441932442228297Methanocaldococcus fervens AG86, complete genomeVacuolar H+transporting two-sector ATPase F subunit4e-0856.6
NC_000909:201000:209008209008209304297Methanocaldococcus jannaschii DSM 2661, complete genomeV-type ATP synthase subunit F8e-0855.8
NC_007681:1300068:130903313090331309353321Methanosphaera stadtmanae DSM 3091, complete genomeAhaF1e-0755.5
NC_013407:1610221:161691616169161617212297Methanocaldococcus vulcanius M7, complete genomeVacuolar H+transporting two-sector ATPase F subunit1e-0755.1
NC_015562:627000:636545636545636850306Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATP synthase subunit F5e-0753.1
NC_015216:405657:414387414387414707321Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATP synthase subunit F1e-0651.6
NC_014122:393856:405542405542405835294Methanocaldococcus infernus ME chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit2e-0651.2