Pre_GI: BLASTP Hits

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Query: NC_010723:2735196:2739747 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2739747, End: 2740388, Length: 642

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:293543429354342936075642Clostridium botulinum B str. Eklund 17B, complete genomeV-type ATPase, D subunit4e-121433
NC_008261:2117207:212373021237302124374645Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, D subunit7e-102369
NC_003366:1901898:190842019084201909064645Clostridium perfringens str. 13, complete genomeATP synthase subunit D7e-102369
NC_008262:1795914:179778117977811798425645Clostridium perfringens SM101, complete genomeV-type ATPase, D subunit7e-102369
NC_009697:2680607:268551526855152686165651Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit D2e-92338
NC_012563:2979147:298666729866672987317651Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, D subunit2e-92338
NC_010520:2807429:283366928336692834319651Clostridium botulinum A3 str. Loch Maree, complete genomeV-type ATPase, D subunit4e-92337
NC_008593:841291:855448855448856098651Clostridium novyi NT, complete genomeV-type ATPase, D subunit9e-92335
NC_015425:906969:921056921056921706651Clostridium botulinum BKT015925 chromosome, complete genomeV-type ATPase subunit D2e-89328
NC_013192:815854:830256830256830894639Leptotrichia buccalis DSM 1135, complete genomeV-type ATPase, D subunit2e-74278
NC_010321:2319820:232635023263502326979630Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit D7e-66249
NC_010320:2397395:240560224056022406231630Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit D7e-66249
NC_014964:2301835:230836523083652308988624Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeV-type ATPase subunit D1e-65248
NC_014538:2396559:240476624047662405389624Thermoanaerobacter sp. X513 chromosome, complete genomeV-type ATPase subunit D1e-65248
NC_014377:2033781:205197420519742052600627Thermosediminibacter oceani DSM 16646 chromosome, complete genomeV-type ATPase, D subunit8e-65246
NC_014209:2257316:226520822652082265831624Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,V-type ATPase, D subunit1e-63242
NC_013921:2375900:238379023837902384413624Thermoanaerobacter italicus Ab9 chromosome, complete genomeV-type ATPase, D subunit1e-63242
NC_013315:3214063:321943232194323220100669Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit D2e-63241
NC_017179:3222015:322738432273843228052669Clostridium difficile BI1, complete genomeV-type ATP synthase subunit D2e-63241
NC_009785:130252:142467142467143090624Streptococcus gordonii str. Challis substr. CH1, complete genomeV-type ATPase, D subunit4e-56217
NC_016148:1021138:102576110257611026387627Thermovirga lienii DSM 17291 chromosome, complete genomeV-type ATPase subunit D8e-47186
NC_012804:141914:145408145408146052645Thermococcus gammatolerans EJ3, complete genomeArchaeal/vacuolar-type H+-ATPase, subunit D (atpD)2e-36152
NC_013156:182896:208536208536209186651Methanocaldococcus fervens AG86, complete genomeV-type ATPase, D subunit2e-35149
NC_015562:627000:640311640311640961651Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATP synthase subunit D2e-35149
NC_014222:186876:200412200412201047636Methanococcus voltae A3 chromosome, complete genomeV-type ATPase, D subunit3e-35148
NC_015636:1477221:148322614832261483867642Methanothermococcus okinawensis IH1 chromosome, complete genomeV-type ATP synthase subunit D4e-35147
NC_009135:494949:500567500567501202636Methanococcus maripaludis C5, complete genomeV-type ATPase, D subunit1e-33143
NC_009635:61344:747947479475432639Methanococcus aeolicus Nankai-3 chromosome, complete genomeV-type ATP synthase subunit D1e-33143
NC_005791:1028500:103995910399591040603645Methanococcus maripaludis S2, complete genomeV-type ATP synthase subunit D1e-33142
NC_015847:1119666:113407311340731134717645Methanococcus maripaludis XI chromosome, complete genomeV-type ATP synthase subunit D1e-33142
NC_009637:302881:317145317145317789645Methanococcus maripaludis C7 chromosome, complete genomeV-type ATP synthase subunit D2e-33142
NC_009634:411599:426233426233426877645Methanococcus vannielii SB chromosome, complete genomeV-type ATP synthase subunit D2e-33142
NC_009975:1500978:150600215060021506646645Methanococcus maripaludis C6, complete genomeV-type ATPase, D subunit4e-33140
NC_015574:2057602:207208320720832072727645Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATP synthase subunit D3e-32138
NC_015474:723553:756758756758757402645Pyrococcus sp. NA2 chromosome, complete genomeV-type ATP synthase subunit D6e-32137
NC_000868:1730820:173729717372971737941645Pyrococcus abyssi GE5, complete genomeV-type ATP synthase subunit D5e-32137
NC_003413:181525:195110195110195754645Pyrococcus furiosus DSM 3638, complete genomeV-type ATP synthase subunit D9e-32136
NC_012883:1603744:161116816111681611812645Thermococcus sibiricus MM 739, complete genomeA1A0 ATP synthase, subunit D3e-31135
NC_015216:405657:417885417885418526642Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATP synthase subunit D8e-30130
NC_014507:245344:250436250436251068633Methanoplanus petrolearius DSM 11571 chromosome, complete genomeV-type ATPase subunit D4e-27121
NC_007681:1300068:130517913051791305823645Methanosphaera stadtmanae DSM 3091, complete genomeAhaD1e-26119
NC_013741:1390823:140274614027461403387642Archaeoglobus profundus DSM 5631, complete genomeV-type ATPase, D subunit4e-24111
NC_018876:2403892:240700124070012407618618Methanolobus psychrophilus R15 chromosome, complete genomeV-type ATP synthase subunit D1e-22105
NC_014614:2434017:244290724429072443518612Clostridium sticklandii, complete genomeV-type sodium ATP synthase subunit D2e-1685.9
NC_014315:1042556:106561210656121066229618Nitrosococcus watsoni C-113 chromosome, complete genomeV-type ATPase subunit D8e-1683.6
NC_002689:46243:556225562256269648Thermoplasma volcanium GSS1, complete genomeV-type ATP synthase subunit D3e-1581.6
NC_014624:2211771:223355522335552234181627Eubacterium limosum KIST612 chromosome, complete genomeV-type ATPase4e-1581.3
NC_016885:2091918:215013621501362150735600Pyrobaculum oguniense TE7 chromosome, complete genomeH(+)-transporting ATP synthase, vacuolar type, subunit D9e-1580.1
NC_009376:1:139051390514504600Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeV-type ATPase subunit D1e-1480.1
NC_005877:509877:516774516774517421648Picrophilus torridus DSM 9790, complete genomeV-type ATP synthase subunit D2e-1479
NC_016645:1838405:186876518687651869364600Pyrobaculum sp. 1860 chromosome, complete genomeV-type ATPase subunit D2e-1375.9
NC_003364:402268:421335421335421934600Pyrobaculum aerophilum str. IM2, complete genomeH+-transporting ATP synthase subunit D (atpD)3e-1272
NC_015152:1230995:123099512309951231693699Spirochaeta sp. Buddy chromosome, complete genomeV-type ATP synthase subunit D7e-1270.5
NC_018012:1935500:194824719482471948891645Thiocystis violascens DSM 198 chromosome, complete genomeH(+)-transporting ATP synthase, vacuolar type, subunit D1e-1067
NC_012589:1531725:154075815407581541399642Sulfolobus islandicus L.S.2.15, complete genomeV-type ATPase, D subunit1e-0963.2
NC_012588:1443753:145278614527861453427642Sulfolobus islandicus M.14.25 chromosome, complete genomeV-type ATP synthase subunit D1e-0963.2
NC_012622:1421098:143013114301311430772642Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeV-type ATP synthase subunit D1e-0963.2
NC_012632:1568170:157720315772031577844642Sulfolobus islandicus M.16.27 chromosome, complete genomeV-type ATP synthase subunit D1e-0963.2
NC_012726:1431745:144077814407781441419642Sulfolobus islandicus M.16.4 chromosome, complete genomeV-type ATP synthase subunit D1e-0963.2
NC_013769:1528196:153722915372291537870642Sulfolobus islandicus L.D.8.5 chromosome, complete genomeV-type ATPase subunit D1e-0963.2
NC_017275:1486526:149555814955581496199642Sulfolobus islandicus HVE10/4 chromosome, complete genomeV-type ATPase subunit D1e-0963.2
NC_017276:1335474:134450713445071345148642Sulfolobus islandicus REY15A chromosome, complete genomeV-type ATPase subunit D1e-0963.2
NC_003106:1435295:144323314432331443883651Sulfolobus tokodaii str. 7, complete genomeV-type ATP synthase subunit D2e-0962.8
NC_002754:491695:499646499646500287642Sulfolobus solfataricus P2, complete genomeV-type ATP synthase subunit D5e-0961.2
NC_015518:1052701:106167110616711062312642Acidianus hospitalis W1 chromosome, complete genomeV-type ATPase subunit D6e-0960.8
NC_012623:1119192:112731711273171127958642Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeV-type ATP synthase subunit D2e-0859.3
NC_007181:1295956:132536013253601325989630Sulfolobus acidocaldarius DSM 639, complete genomeV-type ATP synthase subunit D8e-0857
NC_015435:310406:319434319434320075642Metallosphaera cuprina Ar-4 chromosome, complete genomeV-type ATP synthase subunit D1e-0756.6
NC_009440:1857589:186706818670681867709642Metallosphaera sedula DSM 5348 chromosome, complete genomeV-type ATP synthase subunit D1e-0653.1