Pre_GI: BLASTP Hits

Some Help

Query: NC_010723:2735196:2735196 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2735196, End: 2736074, Length: 879

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:293072729307272931614888Clostridium botulinum B str. Eklund 17B, complete genome5,10-methylenetetrahydrofolate reductase9e-161565
NC_008346:1047500:106266710626671063530864Syntrophomonas wolfei subsp. wolfei str. Goettingen, complete5,10-methylenetetrahydrofolate reductase3e-91335
NC_021182:4882494:490282249028224903703882Clostridium pasteurianum BC1, complete genome5,10-methylenetetrahydrofolate reductase5e-79294
NC_014393:139690:154943154943155800858Clostridium cellulovorans 743B chromosome, complete genome5,10-methylenetetrahydrofolate reductase2e-78292
NC_009633:3429972:342997234299723430856885Alkaliphilus metalliredigens QYMF chromosome, complete genomemethylenetetrahydrofolate reductase1e-76286
NC_015602:1949610:196694519669451967841897Lactobacillus kefiranofaciens ZW3 chromosome, complete genomemethylenetetrahydrofolate reductase9e-75280
NC_018528:1932000:193520219352021936134933Lactobacillus helveticus R0052 chromosome, complete genomemethylenetetrahydrofolate reductase6e-74277
NC_015067:998500:101977310197731020627855Bifidobacterium longum subsp. longum JCM 1217, complete genome5,10-methylenetetrahydrofolate reductase2e-67256
NC_014616:1065500:108415210841521085000849Bifidobacterium bifidum S17 chromosome, complete genomeMethylenetetrahydrofolate reductase1e-64246
NC_013192:519600:521173521173522048876Leptotrichia buccalis DSM 1135, complete genome5,10-methylenetetrahydrofolate reductase3e-60232
NC_008529:1133665:114059211405921141257666Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, complete5,10-methylenetetrahydrofolate reductase3e-54212
NC_010080:1885677:188818018881801888845666Lactobacillus helveticus DPC 4571, complete genome5,10-Methylenetetrahydrofolate reductase4e-54211
NC_007514:1475323:149604514960451496914870Chlorobium chlorochromatii CaD3, complete genome5,10-methylenetetrahydrofolate reductase4e-48191
NC_016943:2054688:205754920575492058445897Blastococcus saxobsidens DD2, complete genome5,10-methylenetetrahydrofolate reductase6e-43174
NC_006677:2402282:242095424209542421883930Gluconobacter oxydans 621H, complete genomeMethylenetetrahydrofolate reductase1e-42173
NC_020209:4312892:434982343498234350668846Pseudomonas poae RE*1-1-14, complete genome5,10-methylenetetrahydrofolate reductase2e-42172
NC_015731:2039317:203931720393172040177861Nitrosomonas sp. Is79A3 chromosome, complete genome5,10-methylenetetrahydrofolate reductase6e-42171
NC_014618:4657719:468116946811694682059891Enterobacter cloacae SCF1 chromosome, complete genome5,10-methylenetetrahydrofolate reductase6e-41167
NC_009439:442890:476509476509477354846Pseudomonas mendocina ymp, complete genome5,10-methylenetetrahydrofolate reductase3e-40165
NC_007912:556000:570731570731571624894Saccharophagus degradans 2-40, complete genome5,10-methylenetetrahydrofolate reductase (FADH)1e-38160
NC_004545:15650:525775257753464888Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genome5,10-methylenetetrahydrofolate reductase1e-36153
NC_007484:3035068:303654230365423037435894Nitrosococcus oceani ATCC 19707, complete genome5,10-methylenetetrahydrofolate reductase4e-36151
NC_014643:1123601:1123601112360111246321032Rothia dentocariosa ATCC 17931 chromosome, complete genomemethylenetetrahydrofolate reductase (NAD(P)H)6e-36151
NC_012913:280506:304856304856305740885Aggregatibacter aphrophilus NJ8700, complete genomehypothetical protein1e-35150
NC_008571:365047:386399386399387352954Gramella forsetii KT0803, complete genomemethylenetetrahydrofolate reductase1e-35150
NC_011886:2369980:238887023888702389832963Arthrobacter chlorophenolicus A6, complete genomeMethylenetetrahydrofolate reductase (NAD(P)H)3e-35149
NC_015510:3375205:338782233878223388778957Haliscomenobacter hydrossis DSM 1100 chromosome, complete genome5,10-methylenetetrahydrofolate reductase2e-35149
NC_005061:647567:665107665107666003897Candidatus Blochmannia floridanus, complete genome5,10-methylenetetrahydrofolate reductase9e-35147
NC_010003:335348:342709342709343656948Petrotoga mobilis SJ95, complete genomeMethylenetetrahydrofolate reductase (NAD(P)H)2e-33143
NC_014934:2482934:249315524931552494108954Cellulophaga algicola DSM 14237 chromosome, complete genomemethylenetetrahydrofolate reductase (nad(p)h)4e-33141
NC_014909:662500:680874680874681770897Candidatus Blochmannia vafer str. BVAF chromosome, complete genome5,10-methylenetetrahydrofolate reductase4e-32138
NC_016788:1609011:162308516230851624068984Corynebacterium diphtheriae HC04 chromosome, complete genome5,10-methylenetetrahydrofolate reductase4e-31135
NC_016790:1581411:159548415954841596467984Corynebacterium diphtheriae VA01 chromosome, complete genome5,10-methylenetetrahydrofolate reductase4e-31135
NC_016785:1586546:160062616006261601609984Corynebacterium diphtheriae CDCE 8392 chromosome, complete genome5,10-methylenetetrahydrofolate reductase4e-31135
NC_016800:1639373:165344616534461654429984Corynebacterium diphtheriae BH8 chromosome, complete genome5,10-methylenetetrahydrofolate reductase4e-31135
NC_016787:1605536:161960916196091620592984Corynebacterium diphtheriae HC03 chromosome, complete genome5,10-methylenetetrahydrofolate reductase3e-31135
NC_008260:2961291:296402029640202964847828Alcanivorax borkumensis SK2, complete genome5,10-methylenetetrahydrofolate reductase7e-31134
NC_016799:1667338:168141216814121682395984Corynebacterium diphtheriae 31A chromosome, complete genome5,10-methylenetetrahydrofolate reductase2e-30132
NC_008513:13484:325393253933420882Buchnera aphidicola str. Cc (Cinara cedri), complete genome5,10-methylenetetrahydrofolate reductase2e-29129
NC_017252:31215:501875018751065879Buchnera aphidicola str. TLW03 (Acyrthosiphon pisum) chromosome,5,10-methylenetetrahydrofolate reductase9e-28124
NC_017255:31211:501855018551063879Buchnera aphidicola str. LL01 (Acyrthosiphon pisum) chromosome,5,10-methylenetetrahydrofolate reductase9e-28124
NC_017254:31206:501825018251060879Buchnera aphidicola str. JF98 (Acyrthosiphon pisum) chromosome,5,10-methylenetetrahydrofolate reductase2e-27122
NC_017253:31192:501665016651044879Buchnera aphidicola str. JF99 (Acyrthosiphon pisum) chromosome,5,10-methylenetetrahydrofolate reductase2e-27122
NC_011834:31206:501805018051058879Buchnera aphidicola str. Tuc7 (Acyrthosiphon pisum) chromosome,5,10-methylenetetrahydrofolate reductase2e-27122
NC_004061:31500:502495024951127879Buchnera aphidicola str. Sg (Schizaphis graminum), complete genome5,10-methylenetetrahydrofolate reductase8e-27120
NC_017162:1228723:125258412525841253225642Acinetobacter baumannii 1656-2 chromosome, complete genomemetF2e-25116
NC_015662:15641:344423444235194753Buchnera aphidicola (Cinara tujafilina) chromosome, complete5,10-methylene-tetrahydrofolate dehydrogenase4e-24112
NC_014829:3562478:3565899356589935678151917Bacillus cellulosilyticus DSM 2522 chromosome, complete genomehomocysteine S-methyltransferase9e-1167.8
NC_015949:2156843:2170111217011121719251815Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomehomocysteine S-methyltransferase3e-1065.9
NC_014721:314990:3236203236203254341815Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehomocysteine s-methyltransferase5e-1065.1
NC_014328:4073714:408549840854984086379882Clostridium ljungdahlii ATCC 49587 chromosome, complete genomemethylenetetrahydrofolate reductase5e-0755.5
NC_007168:2631535:2640131264013126419691839Staphylococcus haemolyticus JCSC1435, complete genomebifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein6e-0651.6