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Query: NC_010723:223935:235320 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 235320, End: 235550, Length: 231

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:222016:233389233389233619231Clostridium botulinum B str. Eklund 17B, complete genomepreprotein translocase, SecE subunit2e-35147
NC_009617:163466:176129176129176359231Clostridium beijerinckii NCIMB 8052 chromosome, complete genomepreprotein translocase subunit SecE1e-21101
NC_020291:166500:177668177668177901234Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomepreprotein translocase, SecE subunit, bacterial2e-21101
NC_008262:2598920:263491526349152635139225Clostridium perfringens SM101, complete genomepreprotein translocase, SecE subunit1e-1375.1
NC_021182:4557608:459227445922744592498225Clostridium pasteurianum BC1, complete genomepreprotein translocase, SecE subunit3e-1063.9
NC_012563:3956500:399116939911693991396228Clostridium botulinum A2 str. Kyoto, complete genomepreprotein translocase, SecE subunit2e-0961.6
NC_010516:3759136:379424037942403794467228Clostridium botulinum B1 str. Okra, complete genomepreprotein translocase, SecE subunit2e-0961.6
NC_009495:3688138:372324337232433723470228Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepreprotein translocase subunit SecE2e-0961.6
NC_009698:3553365:359634135963413596568228Clostridium botulinum A str. Hall chromosome, complete genomepreprotein translocase subunit SecE2e-0961.6
NC_010520:3788702:382384138238413824068228Clostridium botulinum A3 str. Loch Maree, complete genomepreprotein translocase, SecE subunit3e-0857
NC_017295:3250451:328513532851353285359225Clostridium acetobutylicum EA 2018 chromosome, complete genomepreprotein translocase subunit SecE2e-0754.7
NC_003030:3251941:328587832858783286108231Clostridium acetobutylicum ATCC 824, complete genomePreprotein translocase subunit SecE2e-0754.7
NC_015687:3252233:328750532875053287735231Clostridium acetobutylicum DSM 1731 chromosome, complete genomepreprotein translocase subunit SecE2e-0754.7
NC_015425:198315:224268224268224489222Clostridium botulinum BKT015925 chromosome, complete genomePreprotein translocase secE subunit4e-0753.5