Pre_GI: BLASTP Hits

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Query: NC_010723:223935:232933 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 232933, End: 233553, Length: 621

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:222016:231001231001231621621Clostridium botulinum B str. Eklund 17B, complete genomeRNA polymerase sigma-H factor9e-115412
NC_009617:163466:173671173671174342672Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeRNA polymerase factor sigma-704e-99360
NC_020291:166500:175261175261175881621Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRNA polymerase sigma-H factor SigH2e-97355
NC_009698:3553365:359847835984783599119642Clostridium botulinum A str. Hall chromosome, complete genomeRNA polymerase factor sigma-705e-92336
NC_012563:3956500:399330639933063993947642Clostridium botulinum A2 str. Kyoto, complete genomeRNA polymerase sigma-H factor5e-92336
NC_010520:3788702:382597838259783826619642Clostridium botulinum A3 str. Loch Maree, complete genomeRNA polymerase sigma-H factor5e-92336
NC_010516:3759136:379637737963773797018642Clostridium botulinum B1 str. Okra, complete genomeRNA polymerase sigma-H factor5e-92336
NC_008593:196257:216937216937217596660Clostridium novyi NT, complete genomeRNA polymerase sigma-H factor1e-90332
NC_015425:198315:221558221558222268711Clostridium botulinum BKT015925 chromosome, complete genomeRNA polymerase sigma-H factor2e-90331
NC_008262:2598920:263694326369432637590648Clostridium perfringens SM101, complete genomeRNA polymerase sigma-H factor7e-90329
NC_021182:4557608:459439445943944595038645Clostridium pasteurianum BC1, complete genomeRNA polymerase sigma-H factor3e-89327
NC_009495:3688138:372538037253803725952573Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeRNA polymerase factor sigma-705e-89327
NC_017295:3250451:328740932874093288047639Clostridium acetobutylicum EA 2018 chromosome, complete genomeRNA polymerase factor sigma-707e-84309
NC_015687:3252233:328977932897793290417639Clostridium acetobutylicum DSM 1731 chromosome, complete genomeRNA polymerase factor sigma-707e-84309
NC_003030:3251941:328815232881523288790639Clostridium acetobutylicum ATCC 824, complete genomeRNA polymerase sigma-70 factor2e-83308
NC_014393:4482896:452051745205174521170654Clostridium cellulovorans 743B chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily3e-81301
NC_009633:4563877:459642045964204597061642Alkaliphilus metalliredigens QYMF chromosome, complete genomeRNA polymerase factor sigma-706e-81299
NC_010424:214640:219240219240219890651Candidatus Desulforudis audaxviator MP104C, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily1e-80299
NC_013216:293571:293571293571294215645Desulfotomaculum acetoxidans DSM 771, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily3e-80297
NC_010718:193231:199476199476200117642Natranaerobius thermophilus JW/NM-WN-LF, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily5e-79293
NC_019970:336472:364927364927365571645Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeRNA polymerase sigma-H factor2e-78291
NC_015555:327562:335253335253335897645Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeRNA polymerase, sigma-24 subunit, SigH, ECF subfamily2e-78291
NC_014410:403776:411426411426412070645Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,RNA polymerase, sigma-24 subunit, ECF subfamily3e-78291
NC_017208:108134:111911111911112570660Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeRNA polymerase factor sigma-705e-78290
NC_014171:109280:109860109860110519660Bacillus thuringiensis BMB171 chromosome, complete genomeRNA polymerase factor sigma-704e-78290
NC_015958:2251619:231219523121952312839645Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeECF subfamily RNA polymerase sigma-24 subunit SigH2e-77288
NC_010321:393000:400932400932401576645Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeRNA polymerase factor sigma-703e-77287
NC_010320:881351:886863886863887507645Thermoanaerobacter sp. X514 chromosome, complete genomeRNA polymerase factor sigma-703e-77287
NC_014964:388458:396348396348396992645Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeRNA polymerase sigma-H factor3e-77287
NC_014220:2265882:227790422779042278557654Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily6e-75280
NC_010382:4479464:448226744822674482914648Lysinibacillus sphaericus C3-41, complete genomeRNA polymerase sigma-H factor (sigma-30)4e-73273
NC_004193:119737:122942122942123595654Oceanobacillus iheyensis HTE831, complete genomeRNA polymerase sigma-70 factor4e-69260
NC_017294:1457262:148663114866311487272642Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeRNA polymerase sigma-H factor2e-68258
NC_015913:1491393:152024115202411520882642Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomeRNA polymerase factor sigma-702e-68258
NC_019978:178277:179975179975180622648Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma-H factor2e-67254
NC_014652:757381:775730775730776464735Caldicellulosiruptor hydrothermalis 108 chromosome, completeRNA polymerase, sigma-24 subunit, ecf subfamily1e-65248
NC_014392:1935130:195037219503721951106735Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily5e-65247
NC_013316:81969:867408674087402663Clostridium difficile R20291, complete genomeRNA polymerase sigma-H factor2e-64244
NC_015520:2280643:230498623049862305636651Mahella australiensis 50-1 BON chromosome, complete genomeRNA polymerase sigma-30 subunit SigH5e-59226
NC_019978:2260395:228220222822022282888687Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma factor, sigma-70 family4e-41167
NC_015737:2146953:214637521463752146956582Clostridium sp. SY8519, complete genomeDNA-directed RNA polymerase specialized sigma subunit2e-33142
NC_013205:576583:602372602372603001630Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,RNA polymerase, sigma-24 subunit, ECF subfamily8e-25113
NC_013207:19154:401344013440763630Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446RNA polymerase, sigma-24 subunit, ECF subfamily2e-24112
NC_017167:1648913:171892317189231719552630Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1ECF subfamily RNA polymerase sigma-24 subunit6e-24110
NC_017167:2298962:232631423263142326943630Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1ECF subfamily RNA polymerase sigma-24 subunit7e-24110
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome1e-0756.6
NC_007298:2170181:217566021756602176259600Dechloromonas aromatica RCB, complete genomeRNA polymerase sigma-70 factor4e-0754.7
NC_014551:483773:484547484547485335789Bacillus amyloliquefaciens DSM 7, complete genomeRNA polymerase sigma-37 factor (sigma(B))7e-0753.9
NC_017188:461177:461951461951462739789Bacillus amyloliquefaciens TA208 chromosome, complete genomeRNA polymerase sigma factor SigB7e-0753.9
NC_017190:466236:466684466684467472789Bacillus amyloliquefaciens LL3 chromosome, complete genomeRNA polymerase sigma-37 factor (sigma(B))7e-0753.9
NC_017191:467207:467981467981468769789Bacillus amyloliquefaciens XH7 chromosome, complete genomeRNA polymerase sigma factor SigB7e-0753.9
NC_020410:495184:495958495958496746789Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeRNA polymerase sigma-B factor9e-0753.5
NC_009725:496443:497217497217498005789Bacillus amyloliquefaciens FZB42, complete genomeSigB9e-0753.5
NC_019842:484933:485381485381486169789Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,RNA polymerase sigma factor SigB9e-0753.5
NC_004193:375416:655820655820656611792Oceanobacillus iheyensis HTE831, complete genomesigma factor B9e-0753.5
NC_014479:509919:510693510693511481789Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeRNA polymerase sigma factor SigB2e-0652.8
NC_016047:637778:639621639621640409789Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeRNA polymerase sigma-B factor1e-0652.8
NC_014219:567033:568900568900569706807Bacillus selenitireducens MLS10 chromosome, complete genometranscriptional regulator, LuxR family2e-0652
NC_018704:347948:352252352252353040789Amphibacillus xylanus NBRC 15112, complete genomeRNA polymerase sigma-B factor6e-0650.8
NC_013515:550464:5673445673445684831140Streptobacillus moniliformis DSM 12112, complete genomeRNA polymerase, sigma 70 subunit, RpoD subfamily6e-0650.8
NC_016629:3396500:3420075342007534218591785Desulfovibrio africanus str. Walvis Bay chromosome, completeRpoD subfamily RNA polymerase sigma-70 subunit8e-0650.4
NC_012912:1200000:122636512263651226940576Dickeya zeae Ech1591, complete genomeRNA polymerase, sigma-24 subunit, ECF subfamily9e-0650.4