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Query: NC_010723:223935:225704 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 225704, End: 226798, Length: 1095

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:222016:2237852237852248791095Clostridium botulinum B str. Eklund 17B, complete genomepin/tram domain protein4e-177620
NC_020291:166500:1680001680001691001101Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomePilT/Pin/TRAM domain-containing protein1e-135483
NC_009617:163466:1663881663881674881101Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePilT domain-containing protein3e-132471
NC_008262:2598920:2644741264474126458471107Clostridium perfringens SM101, complete genomePIN/TRAM domain protein1e-115416
NC_014393:4482896:4526109452610945272001092Clostridium cellulovorans 743B chromosome, complete genomePilT protein domain-containing protein8e-102370
NC_019970:336472:3535113535113546141104Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeintegral membrane protein (PIN domain superfamily)8e-100363
NC_008593:196257:2108032108032118821080Clostridium novyi NT, complete genomeMembrane-associated protein4e-94345
NC_009633:4563877:4606339460633946074421104Alkaliphilus metalliredigens QYMF chromosome, complete genomePilT domain-containing protein1e-93343
NC_015425:198315:2154342154342165491116Clostridium botulinum BKT015925 chromosome, complete genomePIN/TRAM domain-containing protein5e-92338
NC_002570:126500:1401361401361412241089Bacillus halodurans C-125, complete genomehypothetical protein4e-87321
NC_013316:1:4786147861489551095Clostridium difficile R20291, complete genomehypothetical protein1e-85317
NC_017208:64500:1037621037621048651104Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-81302
NC_014378:131810:1520641520641531881125Acetohalobium arabaticum DSM 5501 chromosome, complete genomePilT protein domain protein9e-81300
NC_018704:81733:1132481132481143571110Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein1e-80300
NC_007503:2098980:2098980209898021000651086Carboxydothermus hydrogenoformans Z-2901, complete genomePIN/TRAM domain protein1e-80300
NC_011899:86800:1099341099341110281095Halothermothrix orenii H 168, complete genomePilT protein domain protein2e-78293
NC_019903:421000:4336704336704348391170Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,integral membrane protein4e-78291
NC_010382:4479464:4490259449025944913441086Lysinibacillus sphaericus C3-41, complete genomehypothetical protein6e-75281
NC_013792:33893:3389333893349811089Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequencehypothetical protein2e-74279
NC_012673:1600242:1600978160097816020421065Exiguobacterium sp. AT1b, complete genomePilT protein domain protein3e-74279
NC_015275:3594890:3629710362971036307651056Clostridium lentocellum DSM 5427 chromosome, complete genomePilT protein domain protein8e-72270
NC_014960:3375807:3400231340023134013131083Anaerolinea thermophila UNI-1, complete genomehypothetical protein2e-69262
NC_011297:1296968:130221213022121303021810Dictyoglomus thermophilum H-6-12, complete genomepin/tram domain protein3e-66252
NC_010999:2450974:2466321246632124674361116Lactobacillus casei, complete genomeIntegral membrane protein, PIN and TRAM domains2e-64246
NC_016148:951446:9713159713159724631149Thermovirga lienii DSM 17291 chromosome, complete genometwitching motility protein PilT6e-63241
NC_004461:277291:2891102891102901681059Staphylococcus epidermidis ATCC 12228, complete genomehypothetical protein2e-50199
NC_017243:3093393:311148631114863112148663Brachyspira intermedia PWS/A chromosome, complete genomeIntegral membrane protein8e-49194
NC_014221:2392150:239910923991092400083975Truepera radiovictrix DSM 17093 chromosome, complete genomePilT protein domain protein5e-40165
NC_007516:774489:8108998108998120561158Synechococcus sp. CC9605, complete genomeNucleotide binding protein, PINc2e-39163
NC_011295:779569:7860367860367870401005Coprothermobacter proteolyticus DSM 5265, complete genomeconserved membrane protein, contains PIN domain3e-31135