Pre_GI: BLASTP Hits

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Query: NC_010723:2231834:2253763 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2253763, End: 2254536, Length: 774

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:245330824533082454081774Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein4e-138490
NC_010465:3958766:397103139710313971807777Yersinia pseudotuberculosis YPIII, complete genomeprotein of unknown function DUF3287e-60230
NC_010159:809663:822959822959823735777Yersinia pestis Angola, complete genomehypothetical protein7e-60230
NC_006155:713174:716213716213716989777Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein7e-60230
NC_003143:483395:488896488896489672777Yersinia pestis CO92, complete genomehypothetical protein7e-60230
NC_009708:3903598:391585439158543916630777Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein7e-60230
NC_014029:536000:542389542389543165777Yersinia pestis Z176003 chromosome, complete genomehypothetical protein7e-60230
NC_017154:478000:484540484540485316777Yersinia pestis D106004 chromosome, complete genomehypothetical protein7e-60230
NC_017160:479411:486732486732487508777Yersinia pestis D182038 chromosome, complete genomehypothetical protein7e-60230
NC_009381:3596000:360936236093623610141780Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein7e-60230
NC_004088:4116676:412892841289284129707780Yersinia pestis KIM, complete genomehypothetical protein7e-60230
NC_008150:4561633:456713445671344567913780Yersinia pestis Antiqua, complete genomehypothetical protein7e-60230
NC_008149:402599:408100408100408879780Yersinia pestis Nepal516, complete genomehypothetical protein7e-60230
NC_005810:4224500:423536342353634236142780Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein7e-60230
NC_017168:601928:614183614183614959777Yersinia pestis A1122 chromosome, complete genomehypothetical protein7e-60230
NC_016612:2223357:222335722233572224130774Klebsiella oxytoca KCTC 1686 chromosome, complete genomehypothetical protein4e-59228
NC_017265:3982020:399427539942753995051777Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein4e-59228
NC_008309:502983:522087522087522863777Haemophilus somnus 129PT, complete genomehypothetical protein2e-54212
NC_005085:1269787:131562713156271316400774Chromobacterium violaceum ATCC 12472, complete genomehypothetical protein7e-51200
NC_002928:3715492:371674537167453717518774Bordetella parapertussis 12822, complete genomehypothetical protein6e-49194
NC_002929:2589202:259309925930992593872774Bordetella pertussis Tohama I, complete genomehypothetical protein6e-49194
NC_002927:4130697:413195041319504132723774Bordetella bronchiseptica RB50, complete genomehypothetical protein6e-49194
NC_015160:797780:819818819818820585768Odoribacter splanchnicus DSM 20712 chromosome, complete genomehypothetical protein4e-48191
NC_019814:678404:700971700971701675705Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonashypothetical protein9e-41167
NC_007109:808331:825901825901826647747Rickettsia felis URRWXCal2, complete genomehypothetical protein6e-36150
NC_020291:4246500:425984242598424260582741Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein8e-35147
NC_011830:259121:272435272435273190756Desulfitobacterium hafniense DCB-2, complete genomeprotein of unknown function DUF3281e-34146
NC_007907:321537:346832346832347587756Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-34146
NC_015977:3215770:322410932241093224858750Roseburia hominis A2-183 chromosome, complete genomehypothetical protein6e-33140
NC_008610:1068429:109134110913411092075735Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica),4e-31135
NC_010001:1917456:192894619289461929713768Clostridium phytofermentans ISDg, complete genomeprotein of unknown function DUF3283e-29129
NC_009953:3552738:355976535597653560622858Salinispora arenicola CNS-205 chromosome, complete genomehypothetical protein2e-27122
NC_019815:114288:120085120085120588504Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneihypothetical protein3e-26118
NC_009380:3346132:334768733476873348478792Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein7e-26117
NC_003454:249304:255348255348256094747Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeProtein yaaA4e-21102
NC_012466:1367099:138255713825571383285729Streptococcus pneumoniae JJA, complete genomehypothetical protein2e-1376.3
NC_011900:1451545:146969914696991470427729Streptococcus pneumoniae ATCC 700669, complete genomehypothetical protein2e-1376.3
NC_013853:1538748:155371515537151554443729Streptococcus mitis B6, complete genomehypothetical protein2e-1376.3
NC_003098:1372875:138967113896711390399729Streptococcus pneumoniae R6, complete genomehypothetical protein5e-1375.1
NC_012469:1403412:141817314181731418901729Streptococcus pneumoniae Taiwan19F-14, complete genomehypothetical protein5e-1375.1
NC_008533:1380406:139720213972021397930729Streptococcus pneumoniae D39, complete genomehypothetical protein5e-1375.1
NC_012468:1453763:146886014688601469588729Streptococcus pneumoniae 70585, complete genomehypothetical protein9e-1373.9