Pre_GI: BLASTP Hits

Some Help

Query: NC_010723:2231834:2251741 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2251741, End: 2252799, Length: 1059

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014614:478578:4976074976074986891083Clostridium sticklandii, complete genomeputative Secretion protein HlyD family protein precursor2e-37156
NC_009253:3317533:3321619332161933226801062Desulfotomaculum reducens MI-1 chromosome, complete genomesecretion protein HlyD family protein4e-2099
NC_015172:2986867:3026377302637730273961020Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomesecretion protein HlyD family protein3e-1583.2
NC_020829:4390417:439398043939804394951972Pseudomonas denitrificans ATCC 13867, complete genomehypothetical protein2e-1273.9
NC_016148:463840:4627944627944638431050Thermovirga lienii DSM 17291 chromosome, complete genomeRND family efflux transporter MFP subunit1e-1170.9
NC_011296:102650:1202461202461213401095Thermodesulfovibrio yellowstonii DSM 11347, complete genomemultidrug resistance protein A2e-1067
NC_011146:2916223:2930688293068829317371050Geobacter bemidjiensis Bem, complete genomesecretion protein HlyD family protein6e-1065.5
NC_015589:1468774:1481742148174214828481107Desulfotomaculum ruminis DSM 2154 chromosome, complete genomesecretion protein HlyD family protein5e-1065.5
NC_009454:1577319:158027115802711581248978Pelotomaculum thermopropionicum SI, complete genomemembrane-fusion protein7e-1065.1
NC_016776:3691453:3701310370131037023771068Bacteroides fragilis 638R, complete genomeputative HlyD-family secretion protein9e-1064.7
NC_006347:3735887:3748215374821537492821068Bacteroides fragilis YCH46, complete genomeputative multidrug resistance protein1e-0964.3
NC_003228:3645426:3655818365581836568851068Bacteroides fragilis NCTC 9343, complete genomeputative HlyD-family secretion protein2e-0963.9
NC_013520:1559000:1563659156365915647051047Veillonella parvula DSM 2008, complete genomesecretion protein HlyD family protein3e-0963.2
NC_004547:442927:480919480919481917999Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein4e-0962.8
NC_010337:1561430:1590063159006315912831221Heliobacterium modesticaldum Ice1, complete genomehlyd family secretion protein7e-0961.6
NC_008609:2840249:2861093286109328622201128Pelobacter propionicus DSM 2379, complete genomesecretion protein HlyD family protein9e-0961.6
NC_005085:786851:7883967883967895441149Chromobacterium violaceum ATCC 12472, complete genomemultidrug resistance secretion protein1e-0861.2
NC_009633:365325:3984453984453996051161Alkaliphilus metalliredigens QYMF chromosome, complete genomeRND family efflux transporter MFP subunit2e-0860.5
NC_011894:6516856:6527624652762465288021179Methylobacterium nodulans ORS 2060, complete genomesecretion protein HlyD family protein2e-0860.5
NC_014152:927969:927969927969928622654Thermincola sp. JR, complete genomesecretion protein HlyD family protein3e-0860.1
NC_009254:442360:4644044644044657171314Burkholderia vietnamiensis G4 chromosome 3, complete sequencesecretion protein HlyD family protein3e-0859.7
NC_014840:76232:7780277802789201119Pantoea sp. At-9b plasmid pPAT9B03, complete sequencesecretion protein HlyD family protein4e-0859.3
NC_011296:102650:1225931225931237531161Thermodesulfovibrio yellowstonii DSM 11347, complete genomeefflux transporter, RND family, MFP subunit4e-0859.3
NC_009483:3608000:3611298361129836123021005Geobacter uraniireducens Rf4 chromosome, complete genomesecretion protein HlyD family protein9e-0858.2
NC_004459:3243987:3267688326768832689171230Vibrio vulnificus CMCP6 chromosome I, complete sequenceMultidrug resistance efflux pump3e-0756.2
NC_009092:261778:2718842718842729901107Shewanella loihica PV-4, complete genomesecretion protein HlyD family protein3e-0756.2
NC_010125:2884762:293819829381982939190993Gluconacetobacter diazotrophicus PAl 5, complete genomeputative multidrug resistance protein4e-0755.8
NC_008027:2909000:291349929134992914254756Pseudomonas entomophila L48, complete genomemultidrug resistance efflux pump, partial with no TM helices (HlyD family)4e-0755.8
NC_020291:270234:2968942968942983121419Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomemultidrug resistance efflux pump4e-0755.8
NC_010505:5525461:5567586556758655685871002Methylobacterium radiotolerans JCM 2831, complete genomesecretion protein HlyD family protein4e-0755.8
NC_021182:300415:3045853045853058981314Clostridium pasteurianum BC1, complete genomeRND family efflux transporter, MFP subunit6e-0755.5
NC_016002:2453919:2467730246773024688691140Pseudogulbenkiania sp. NH8B, complete genomemultidrug resistance protein A7e-0755.1
NC_010334:609636:6096366096366107091074Shewanella halifaxensis HAW-EB4, complete genomesecretion protein HlyD family protein1e-0654.3
NC_012779:2957000:2981308298130829824861179Edwardsiella ictaluri 93-146, complete genomemultidrug resistance protein A2e-0653.9
NC_009654:91096:1080051080051090691065Marinomonas sp. MWYL1, complete genomesecretion protein HlyD family protein2e-0653.9
NC_019757:5852000:5852005585200558533601356Cylindrospermum stagnale PCC 7417, complete genomeRND family efflux transporter, MFP subunit2e-0653.5
NC_004741:2456297:2463378246337824645411164Shigella flexneri 2a str. 2457T, complete genomemultidrug resistance protein K2e-0653.5
NC_004337:2478461:2485239248523924864021164Shigella flexneri 2a str. 301, complete genomemultidrug resistance protein K2e-0653.5
NC_008258:2473000:2478978247897824801411164Shigella flexneri 5 str. 8401, complete genomemultidrug resistance protein K2e-0653.5
NC_017328:2516000:2522881252288125240441164Shigella flexneri 2002017 chromosome, complete genomeMultidrug resistance protein K2e-0653.5
NC_012846:1741000:1755512175551217566061095Bartonella grahamii as4aup, complete genomemultidrug resistance protein VceA3e-0653.1
NC_007613:2376974:2384108238410823852711164Shigella boydii Sb227, complete genomemultidrug resistance protein K4e-0652.8
NC_008253:2499735:2505611250561125066511041Escherichia coli 536, complete genomemultidrug resistance protein K4e-0652.8
NC_002655:3260500:3280272328027232814351164Escherichia coli O157:H7 EDL933, complete genomemultidrug resistance protein K4e-0652.8
NC_002695:3189425:3210313321031332114761164Escherichia coli O157:H7 str. Sakai, complete genomemultidrug resistance protein K4e-0652.8
NC_011745:2751437:2756919275691927580821164Escherichia coli ED1a chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.8
NC_007946:2625461:2643444264344426446071164Escherichia coli UTI89, complete genomemultidrug resistance protein K4e-0652.8
NC_007606:2353098:2358987235898723601501164Shigella dysenteriae Sd197, complete genomemultidrug resistance protein K4e-0652.8
NC_010658:2529033:2536873253687325380361164Shigella boydii CDC 3083-94, complete genomedrug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK4e-0652.8
AP010958:2911741:2933173293317329343361164Escherichia coli O103:H2 str. 12009 DNA, complete genomeEmrKY-TolC multidrug resistance efflux pump protein K, membrane fusion protein component4e-0652.8
NC_016822:2678691:2686159268615926873221164Shigella sonnei 53G, complete genomemultidrug resistance protein K4e-0652.8
NC_007384:2587876:2595344259534425965071164Shigella sonnei Ss046, complete genomemultidrug resistance protein K4e-0652.8
NC_010161:1844452:1858232185823218593261095Bartonella tribocorum CIP 105476, complete genomemultidrug resistance efflux pump VceA protein4e-0652.8
NC_011741:2513000:2519046251904625202091164Escherichia coli IAI1 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.8
CU928160:2513000:2519046251904625202091164Escherichia coli IAI1 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.8
NC_008563:2610499:2615981261598126170361056Escherichia coli APEC O1, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein4e-0652.8
NC_013353:2911741:2933173293317329343361164Escherichia coli O103:H2 str. 12009, complete genomeEmrKY-TolC multidrug resistance efflux pump protein K, membrane fusion protein component4e-0652.8
AC_000091:2462461:2487622248762224887851164Escherichia coli W3110 DNA, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_016902:1419413:1438059143805914392221164Escherichia coli KO11FL chromosome, complete genomeefflux pump membrane protein5e-0652.4
NC_013008:3231414:3269300326930032704631164Escherichia coli O157:H7 str. TW14359 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component5e-0652.4
NC_011415:2732000:2750284275028427514471164Escherichia coli SE11 chromosome, complete genomemultidrug resistance protein5e-0652.4
NC_011353:3276734:3314429331442933155921164Escherichia coli O157:H7 str. EC4115 chromosome, complete genomedrug resistance MFS transporter membrane fusion protein (MFP) subunit EmrK5e-0652.4
CP002185:2659628:2666635266663526677981164Escherichia coli W, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component5e-0652.4
CP002516:1419413:1438059143805914392221164Escherichia coli KO11, complete genomeefflux pump membrane protein5e-0652.4
NC_011601:2614691:2638590263859026397531164Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump protein K, membrane fusion protein component5e-0652.4
NC_016609:1774259:1805993180599318070571065Niastella koreensis GR20-10 chromosome, complete genomesecretion protein HlyD family protein5e-0652.4
NC_005956:1402500:1415905141590514169661062Bartonella henselae str. Houston-1, complete genomeMultidrug resistance protein vceA5e-0652.4
CU928145:2708500:2714557271455727157201164Escherichia coli 55989 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_011748:2708500:2714557271455727157201164Escherichia coli 55989, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_009800:2505872:2513581251358125147441164Escherichia coli HS, complete genomedrug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK4e-0652.4
NC_013941:2928000:2951379295137929525421164Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeDrug resistance MFS transporter membrane fusion protein (MFP) subunit EmrK4e-0652.4
NC_004431:2747237:2764564276456427657271164Escherichia coli CFT073, complete genomeMultidrug resistance protein K4e-0652.4
NC_012967:2409500:2416403241640324175661164Escherichia coli B str. REL606 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_012947:1363724:1378677137867713798401164Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeefflux pump membrane protein4e-0652.4
NC_012759:2342986:2366003236600323671661164Escherichia coli BW2952 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_011742:2533500:2539076253907625402391164Escherichia coli S88 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_000913:2455037:2480198248019824813611164Escherichia coli K12, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_010498:2555706:2572996257299625741591164Escherichia coli SMS-3-5, complete genomedrug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK4e-0652.4
NC_010473:2548946:2571963257196325731261164Escherichia coli str. K-12 substr. DH10B, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component4e-0652.4
NC_010468:1412791:1427744142774414289071164Escherichia coli ATCC 8739, complete genomeefflux pump membrane protein4e-0652.4
NC_011750:2585015:2603978260397826051411164Escherichia coli IAI39 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component7e-0652
NC_011751:2768864:2774763277476327759261164Escherichia coli UMN026 chromosome, complete genomeEmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component7e-0652
NC_014932:1232346:1272744127274412738441101Bartonella clarridgeiae 73, complete genomemultidrug resistance efflux pump VceA protein9e-0651.6
NC_014206:2971304:299208129920812993025945Geobacillus sp. C56-T3 chromosome, complete genomebiotin/lipoyl attachment domain-containing protein9e-0651.6