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Query: NC_010723:2231834:2250477 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2250477, End: 2251730, Length: 1254

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014614:478578:4964474964474975951149Clostridium sticklandii, complete genomeconserved membrane protein of unknown function6e-30132
NC_015172:2986867:3025179302517930263631185Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeABC-2 type transporter9e-25115
NC_013385:1007616:1007616100761610087911176Ammonifex degensii KC4, complete genomeABC-2 type transporter6e-2099
NC_014614:478578:4953514953514964541104Clostridium sticklandii, complete genomemembrane protein of unknown function1e-1791.3
NC_016510:4343:4343434355121170Flavobacterium columnare ATCC 49512 chromosome, complete genomeABC-2 type transporter2e-1480.1
NC_009454:1577319:1577319157731915784281110Pelotomaculum thermopropionicum SI, complete genomeABC-type multidrug transport system, permease component4e-1376.3
NC_016629:415711:4284654284654295831119Desulfovibrio africanus str. Walvis Bay chromosome, completeABC-2 type transporter9e-1375.1
NC_014655:2747399:2750437275043727515881152Leadbetterella byssophila DSM 17132 chromosome, complete genomeabc-2 type transporter1e-1275.1
NC_010723:2231834:2249281224928122504771197Clostridium botulinum E3 str. Alaska E43, complete genomeputative ABC-2 type transporter2e-1274.3
NC_007759:2858240:2860098286009828612071110Syntrophus aciditrophicus SB, complete genomeexport ABC transporter permease protein1e-1068.2
NC_009253:3317533:3323384332338433245141131Desulfotomaculum reducens MI-1 chromosome, complete genomeABC-2 type transporter2e-1067
NC_002939:3108907:3108907310890731100401134Geobacter sulfurreducens PCA, complete genomehypothetical protein3e-0963.5
NC_009253:3317533:3324528332452833257211194Desulfotomaculum reducens MI-1 chromosome, complete genomeABC-2 type transporter2e-0861.2
NC_015501:556994:5747935747935759291137Porphyromonas asaccharolytica DSM 20707 chromosome, completeABC-2 type transporter2e-0860.5
NC_011296:1542835:1557198155719815583221125Thermodesulfovibrio yellowstonii DSM 11347, complete genomeABC-2 type transporter6e-0858.9
NC_007759:2858240:2861146286114628623481203Syntrophus aciditrophicus SB, complete genomeexport ABC transporter permease protein6e-0858.9
NC_010943:1426885:1451191145119114523181128Stenotrophomonas maltophilia K279a, complete genomeputative transmembrane protein3e-0757
NC_011027:1153592:1157948115794811590571110Chlorobaculum parvum NCIB 8327, complete genomeABC-2 type transporter1e-0655.1
NC_011296:1542835:1558319155831915594521134Thermodesulfovibrio yellowstonii DSM 11347, complete genomeATPase component ABC-type multidrug transport system4e-0653.1
NC_017249:3406570:3419551341955134218812331Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein4e-0652.8