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Query: NC_010723:2231834:2249281 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2249281, End: 2250477, Length: 1197

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014614:478578:4953514953514964541104Clostridium sticklandii, complete genomemembrane protein of unknown function1e-31137
NC_015172:2986867:3025179302517930263631185Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeABC-2 type transporter2e-21103
NC_016510:4343:4343434355121170Flavobacterium columnare ATCC 49512 chromosome, complete genomeABC-2 type transporter2e-1790.5
NC_013385:1007616:1007616100761610087911176Ammonifex degensii KC4, complete genomeABC-2 type transporter1e-1687.8
NC_014655:2747399:2750437275043727515881152Leadbetterella byssophila DSM 17132 chromosome, complete genomeabc-2 type transporter6e-1582
NC_009253:3317533:3324528332452833257211194Desulfotomaculum reducens MI-1 chromosome, complete genomeABC-2 type transporter9e-1581.6
NC_014614:478578:4964474964474975951149Clostridium sticklandii, complete genomeconserved membrane protein of unknown function1e-1480.9
NC_010723:2231834:2250477225047722517301254Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-1480.5
NC_009454:1577319:1577319157731915784281110Pelotomaculum thermopropionicum SI, complete genomeABC-type multidrug transport system, permease component3e-1480.1
NC_009253:3317533:3323384332338433245141131Desulfotomaculum reducens MI-1 chromosome, complete genomeABC-2 type transporter1e-1378.2
NC_002939:3108907:3110043311004331111731131Geobacter sulfurreducens PCA, complete genomehypothetical protein1e-1274.7
NC_014166:1179335:1196261119626111973431083Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeABC transporter1e-1274.3
NC_014364:3707311:3709170370917037102791110Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeABC-2 type transporter2e-1170.5
NC_011883:1601552:1608075160807516092111137Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774,ABC-2 type transporter6e-1065.5
NC_015164:3099097:3100321310032131015711251Bacteroides salanitronis DSM 18170 chromosome, complete genomeABC-2 type transporter4e-0963.2
NC_003228:2929006:2944478294447829456921215Bacteroides fragilis NCTC 9343, complete genomehypothetical protein3e-0963.2
NC_019940:1837863:1851686185168618527951110Thioflavicoccus mobilis 8321 chromosome, complete genomemultidrug ABC transporter permease3e-0963.2
NC_016776:2913966:2929458292945829306721215Bacteroides fragilis 638R, complete genomehypothetical protein3e-0963.2
NC_006347:2861498:2870907287090728720791173Bacteroides fragilis YCH46, complete genomehypothetical protein4e-0962.8
NC_015574:2322811:2341886234188623430701185Methanobacterium sp. SWAN-1 chromosome, complete genomeABC-2 type transporter5e-0962.8
NC_010995:4297361:4317944431794443190591116Cellvibrio japonicus Ueda107, complete genomeABC-type multidrug transport system, permease component1e-0861.2
NC_007404:1126756:1142066114206611432021137Thiobacillus denitrificans ATCC 25259, complete genomeABC-2 type transport system permease protein2e-0860.5
NC_007759:2858240:2861146286114628623481203Syntrophus aciditrophicus SB, complete genomeexport ABC transporter permease protein1e-0757.8
NC_016845:5162481:5167756516775651688501095Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,putative ABC-type multidrug transport system, permease component3e-0757
NC_014107:171170:1806981806981829592262Enterobacter cloacae subsp. cloacae ATCC 13047 plasmid pECL_A,hypothetical protein3e-0756.6
NC_002939:3108907:3108907310890731100401134Geobacter sulfurreducens PCA, complete genomehypothetical protein4e-0756.2
NC_009648:4359875:4365877436587743670161140Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeputative ABC-type multidrug transport system, permease component4e-0756.2
NC_012731:5074000:5080056508005650811951140Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeputative ABC-type multidrug transport system permease component4e-0756.2
NC_010655:1606901:1644002164400216451141113Akkermansia muciniphila ATCC BAA-835, complete genomeABC-2 type transporter6e-0755.8
NC_013850:109500:1206921206921218311140Klebsiella variicola At-22 chromosome, complete genomeABC-2 type transporter7e-0755.5
NC_011283:105245:1154961154961166351140Klebsiella pneumoniae 342 chromosome, complete genomeABC transporter permease7e-0755.5
NC_017249:3406570:3419551341955134218812331Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein2e-0653.9
NC_011296:1542835:1557198155719815583221125Thermodesulfovibrio yellowstonii DSM 11347, complete genomeABC-2 type transporter5e-0652.8
NC_014166:1179335:1197340119734011984491110Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeABC transporter5e-0652.4
NC_015856:2646816:2649594264959426507451152Collimonas fungivorans Ter331 chromosome, complete genomemultidrug ABC transporter permease9e-0651.6