Pre_GI: BLASTP Hits

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Query: NC_010723:2231834:2247607 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2247607, End: 2247762, Length: 156

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:245035024503502450505156Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein4e-1373.2
NC_009617:4761000:477577747757774775932156Clostridium beijerinckii NCIMB 8052 chromosome, complete genomehypothetical protein4e-1167
NC_009617:1255762:125986112598611260028168Clostridium beijerinckii NCIMB 8052 chromosome, complete genomehypothetical protein6e-1166.2
NC_010723:1084000:108636510863651086520156Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein9e-1165.5
NC_010674:1124431:112526211252621125417156Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein9e-1165.5
NC_020291:1810527:181510518151051815257153Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomezinc-binding domain-containing protein1e-1065.1
NC_010723:1465097:149414114941411494293153Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-1065.1
NC_015425:2277570:229381922938192293977159Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein5e-1063.2
NC_008593:2020473:204057120405712040738168Clostridium novyi NT, complete genomehypothetical protein9e-1062.4
NC_010516:3545017:354645335464533546623171Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-0960.5
NC_014377:1546124:155074215507421551047306Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein3e-0960.5
NC_014410:2149886:217140321714032171597195Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,hypothetical protein1e-0858.2
NC_015519:924000:931273931273931581309Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein2e-0858.2
NC_016048:797762:821339821339821650312Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein3e-0857
NC_009523:2769154:278623227862322786621390Roseiflexus sp. RS-1 chromosome, complete genomehypothetical protein5e-0856.6
NC_016048:1390463:141041914104191410703285Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-0755.1
NC_007644:362000:374298374298374618321Moorella thermoacetica ATCC 39073, complete genomehypothetical protein3e-0753.9
NC_016048:1390463:140120914012091401508300Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-0753.5