Pre_GI: BLASTP Hits

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Query: NC_010723:2231834:2244517 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2244517, End: 2245773, Length: 1257

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:2446534244653424477901257Clostridium botulinum B str. Eklund 17B, complete genomeGntP family permease0678
NC_015565:824448:8346778346778359481272Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeCitrate transporter8e-129460
NC_009848:3582384:3595656359565635969421287Bacillus pumilus SAFR-032, complete genomeGntP family gluconate:proton (H+) symporter1e-127456
NC_011184:2421687:2422960242296024242251266Vibrio fischeri MJ11 chromosome I, complete sequencegluconate permease2e-119429
NC_014632:11925:3266832668339181251Ilyobacter polytropus DSM 2926 chromosome, complete genomecitrate transporter7e-103374
NC_012779:3570720:358662935866293587585957Edwardsiella ictaluri 93-146, complete genomehypothetical protein4e-89328
NC_020207:1346579:1375395137539513766871293Enterococcus faecium NRRL B-2354, complete genomeD-glycerate transporter (predicted)5e-85315
NC_010003:570643:5872715872715886141344Petrotoga mobilis SJ95, complete genomegluconate transporter1e-0965.1
NC_020291:2291418:2297737229773722991311395Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeH+/gluconate symporter family protein7e-0755.5
NC_013093:6511108:6511108651110865125021395Actinosynnema mirum DSM 43827, complete genomegluconate transporter9e-0755.1
NC_014210:4831858:4832956483295648343891434Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,gluconate transporter1e-0654.7
NC_016023:1874827:1884996188499618863421347Bacillus coagulans 36D1 chromosome, complete genomegluconate transporter2e-0654.3
NC_004431:5123325:5144682514468251460251344Escherichia coli CFT073, complete genomeHigh-affinity gluconate transporter2e-0654.3
NC_016928:2517691:2540118254011825414761359Staphylococcus aureus subsp. aureus M013 chromosome, completegluconate permease, Bsu4004-like protein2e-0653.9
NC_016941:2498299:2521380252138025227381359Staphylococcus aureus subsp. aureus MSHR1132, complete genomeputative gluconate permease2e-0653.9
CP002797:4656327:4677849467784946791921344Escherichia coli NA114, complete genomeFructuronate transporter3e-0653.5
CP002516:4199133:4199133419913342004761344Escherichia coli KO11, complete genomegluconate transporter3e-0653.5
AC_000091:4534935:4554633455463345559761344Escherichia coli W3110 DNA, complete genomefructuronate transporter3e-0653.5
NC_009801:4882684:4906902490690249082451344Escherichia coli E24377A, complete genomehigh-affinity gluconate transporter GntP3e-0653.5
NC_010498:4930649:4954576495457649559191344Escherichia coli SMS-3-5, complete genomehigh-affinity gluconate transporter GntP3e-0653.5
CP002185:4791811:4812394481239448137371344Escherichia coli W, complete genomefructuronate transporter3e-0653.5
CU928160:4570498:4610595461059546119381344Escherichia coli IAI1 chromosome, complete genomefructuronate transporter3e-0653.5
NC_000913:4528278:4547976454797645493191344Escherichia coli K12, complete genomefructuronate transporter3e-0653.5
NC_002695:5381576:5404775540477554061181344Escherichia coli O157:H7 str. Sakai, complete genomegluconate transport system permease 33e-0653.5
NC_011750:4978000:4997413499741349987561344Escherichia coli IAI39 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011353:5455224:5478423547842354797661344Escherichia coli O157:H7 str. EC4115 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011741:4570498:4610595461059546119381344Escherichia coli IAI1 chromosome, complete genomefructuronate transporter3e-0653.5
NC_017179:905347:9125869125869139261341Clostridium difficile BI1, complete genomepermease3e-0653.5
NC_013315:895500:9028099028099041491341Clostridium difficile CD196 chromosome, complete genomepermease3e-0653.5
NC_013316:891782:9004249004249017641341Clostridium difficile R20291, complete genomeputative permease3e-0653.5
NC_009089:965959:9731989731989745381341Clostridium difficile 630, complete genomeprobable permease3e-0653.5
NC_004741:4364235:4364235436423543655781344Shigella flexneri 2a str. 2457T, complete genomegluconate transport system permease 33e-0653.5
NC_016902:4199133:4199133419913342004761344Escherichia coli KO11FL chromosome, complete genomegluconate transporter3e-0653.5
NC_013941:5219841:5243056524305652443991344Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeHigh-affinity gluconate transporter3e-0653.5
NC_013008:5411285:5434484543448454358271344Escherichia coli O157:H7 str. TW14359 chromosome, complete genomefructuronate transporter3e-0653.5
NC_012967:4510393:4530867453086745322101344Escherichia coli B str. REL606 chromosome, complete genomefructuronate transporter3e-0653.5
NC_011742:4873351:4892706489270648940491344Escherichia coli S88 chromosome, complete genomefructuronate transporter3e-0653.5
NC_016822:4889656:4911895491189549132381344Shigella sonnei 53G, complete genomefructuronate transporter3e-0653.1
NC_007622:2501562:2511931251193125132891359Staphylococcus aureus RF122, complete genomegluconate permease3e-0653.1
NC_013450:2572530:2590340259034025916981359Staphylococcus aureus subsp. aureus ED98, complete genomegluconate transporter, permease protein5e-0652.8
NC_009641:2619759:2642311264231126436691359Staphylococcus aureus subsp. aureus str. Newman chromosome,gluconate permease5e-0652.8
NC_010079:2618345:2636416263641626377741359Staphylococcus aureus subsp. aureus USA300_TCH1516, completeGntP family gluconate:proton (H+) symporter5e-0652.8
NC_002758:2628000:2645900264590026472581359Staphylococcus aureus subsp. aureus Mu50, complete genomegluconate permease5e-0652.8
NC_003923:2561953:2584171258417125855291359Staphylococcus aureus subsp. aureus MW2, complete genomegluconate permease5e-0652.8
NC_002745:2553138:2575474257547425768321359Staphylococcus aureus subsp. aureus N315, complete genomegluconate permease5e-0652.8
NC_007795:2561928:2584907258490725862651359Staphylococcus aureus subsp. aureus NCTC 8325, complete genomegluconate permease, putative5e-0652.8
NC_002951:2554511:2572964257296425743221359Staphylococcus aureus subsp. aureus COL, complete genomegluconate transporter, permease protein5e-0652.8
NC_016912:2433500:2456118245611824574761359Staphylococcus aureus subsp. aureus VC40 chromosome, completegluconate transporter, permease protein5e-0652.8
NC_017341:2648631:2666532266653226678901359Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,GntP family gluconate:proton (H+) symporter5e-0652.8
NC_020210:2044944:2061065206106520623751311Geobacillus sp. GHH01, complete genomeputative permease4e-0652.8
NC_017342:751496:7582557582557596131359Staphylococcus aureus subsp. aureus TCH60 chromosome, completegluconate:H+ symporter family transporter GntP5e-0652.8
NC_002952:2653482:2664202266420226655601359Staphylococcus aureus subsp. aureus MRSA252, complete genomeputative gluconate permease5e-0652.8
NC_017337:2588331:2599424259942426007821359Staphylococcus aureus subsp. aureus ED133 chromosome, completegluconate permease5e-0652.8
NC_009632:2656296:2674131267413126754891359Staphylococcus aureus subsp. aureus JH1 chromosome, completegluconate transporter5e-0652.8
NC_009487:2656420:2674255267425526756131359Staphylococcus aureus subsp. aureus JH9 chromosome, completegluconate transporter5e-0652.8
NC_017347:2616000:2631270263127026326281359Staphylococcus aureus subsp. aureus T0131 chromosome, completeGluconate permease5e-0652.8
NC_017343:2474743:2495553249555324969111359Staphylococcus aureus subsp. aureus ECT-R 2, complete genomegluconate permease5e-0652.8
NC_020210:3341976:3367120336712033684901371Geobacillus sp. GHH01, complete genomegluconate transporter5e-0652.4
NC_017338:2558825:2576706257670625780641359Staphylococcus aureus subsp. aureus JKD6159 chromosome, completeGntP family gluconate:proton (H+) symporter9e-0652