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Query: NC_010723:2231834:2237503 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2237503, End: 2238555, Length: 1053

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:2440074244007424410811008Clostridium botulinum B str. Eklund 17B, complete genomeYkwD protein2e-165582
NC_004557:2475030:249312024931202493731612Clostridium tetani E88, complete genometransporter3e-2099.8
NC_016048:1580352:1583348158334815846941347Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-2099.4
NC_013192:1765981:178246517824651783061597Leptotrichia buccalis DSM 1135, complete genomeSCP-like extracellular3e-1789.7
NC_016593:3249767:3256003325600332572411239Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completehypothetical protein6e-1788.6
NC_008261:967973:980233980233981186954Clostridium perfringens ATCC 13124, complete genomeSCP-like extracellular family protein9e-1788.2
NC_003366:1013773:101856510185651019518954Clostridium perfringens str. 13, complete genomehypothetical protein9e-1788.2
NC_004557:691944:7116347116347131511518Clostridium tetani E88, complete genomeputative S-layer protein/internalin A-like/N-acetylmuramoyl-L-alanine amidase8e-1685.1
NC_014002:31293:425164251643451936Methanohalophilus mahii DSM 5219 chromosome, complete genomeSCP-like extracellular2e-1584
NC_009633:3429972:343284234328423433804963Alkaliphilus metalliredigens QYMF chromosome, complete genomeSCP-like extracellular protein6e-1582
NC_009925:1617414:163848816384881639192705Acaryochloris marina MBIC11017, complete genomehypothetical protein9e-1581.3
NC_014915:3320768:3325816332581633270481233Geobacillus sp. Y412MC52 chromosome, complete genomeSCP-like extracellular1e-1481.3
NC_013411:3314799:3319847331984733210791233Geobacillus sp. Y412MC61, complete genomeSCP-like extracellular1e-1481.3
NC_015161:354000:356212356212356826615Deinococcus proteolyticus MRP chromosome, complete genomeSCP-like extracellular5e-1479
NC_017098:986428:102378510237851024732948Spirochaeta africana DSM 8902 chromosome, complete genomehypothetical protein2e-1377.4
NC_013526:567500:584388584388585200813Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeSCP-like extracellular3e-1376.3
NC_015730:921735:9319249319249336301707Roseobacter litoralis Och 149 chromosome, complete genomeSCP-like protein2e-1273.6
NC_004193:375416:4119484119484130811134Oceanobacillus iheyensis HTE831, complete genomehypothetical protein3e-1273.2
NC_019757:4739206:476161147616114762168558Cylindrospermum stagnale PCC 7417, complete genomeuncharacterized protein with SCP/PR1 domains6e-1272
NC_013791:1152500:1165916116591611672081293Bacillus pseudofirmus OF4 chromosome, complete genomecopper amine oxidase domain-containing protein2e-1170.5
NC_007484:1694738:171340017134001714107708Nitrosococcus oceani ATCC 19707, complete genomehypothetical protein2e-1066.6
NC_008209:1385094:1395405139540513965801176Roseobacter denitrificans OCh 114, complete genomeSCP-like extracellular protein subfamily, putative4e-1065.9
NC_014958:3346500:337040233704023371364963Deinococcus maricopensis DSM 21211 chromosome, complete genomeSCP-like extracellular3e-0963.2
NC_020829:2022000:202546820254682026316849Pseudomonas denitrificans ATCC 13867, complete genomehypothetical protein2e-0860.5
NC_014002:466994:4781764781764793541179Methanohalophilus mahii DSM 5219 chromosome, complete genomeSCP-like extracellular4e-0859.3
NC_010501:3448389:347324634732463474106861Pseudomonas putida W619, complete genomeSCP-like extracellular3e-0756.2
NC_017243:1229597:125218112521811253062882Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein2e-0653.5