Pre_GI: BLASTP Hits

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Query: NC_010723:2231834:2235380 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2235380, End: 2236177, Length: 798

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:243792624379262438723798Clostridium botulinum B str. Eklund 17B, complete genomelysozyme M17e-147519
NC_010723:915697:934757934757935551795Clostridium botulinum E3 str. Alaska E43, complete genomeglycosyl hydrolase, family 254e-97354
NC_010520:2101515:210740621074062108230825Clostridium botulinum A3 str. Loch Maree, complete genomeautolytic lysozyme (1,4-beta-N-acetylmuramidase)(Autolysin)2e-62238
NC_021182:2765000:276666927666692767508840Clostridium pasteurianum BC1, complete genomelysozyme M1 (1,4-beta-N-acetylmuramidase)2e-29129
NC_012914:1851102:185155018515501852359810Paenibacillus sp. JDR-2, complete genomeglycoside hydrolase family 251e-28127
NC_011837:3226500:324381932438193244739921Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-23108
NC_009706:3291330:331231733123173313237921Clostridium kluyveri DSM 555 chromosome, complete genomeglycosyl hydrolase3e-23108
NC_017295:2022085:2022085202208520231401056Clostridium acetobutylicum EA 2018 chromosome, complete genomeN-acetylmuramidase, autolytic enzyme, family 25 of glycosyl hydrolase2e-21102
NC_021182:338428:361447361447362406960Clostridium pasteurianum BC1, complete genomelysozyme M1 (1,4-beta-N-acetylmuramidase)3e-2099
NC_014483:1179286:119775611977561198721966Paenibacillus polymyxa E681 chromosome, complete genomeLyzozyme M1 (1,4-beta-N-acetylmuramidase)3e-2099
NC_016641:2950000:296913929691392970104966Paenibacillus terrae HPL-003 chromosome, complete genome1,4-beta-N-acetylmuramidase2e-1996.3
NC_016641:3772981:378394537839453784940996Paenibacillus terrae HPL-003 chromosome, complete genomeglycoside hydrolase3e-1892
NC_013517:1823926:182926318292631829970708Sebaldella termitidis ATCC 33386, complete genomeglycoside hydrolase family 253e-1892
NC_014828:501342:5169305169305181051176Ethanoligenens harbinense YUAN-3 chromosome, complete genomeglycoside hydrolase family 257e-1891.3
NC_013730:834500:859135859135859908774Spirosoma linguale DSM 74, complete genomeglycoside hydrolase family 258e-1890.9
NC_002655:2925787:292658529265852927412828Escherichia coli O157:H7 EDL933, complete genomehypothetical protein3e-1789
NC_002695:2854629:285636628563662857193828Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein3e-1789
NC_011353:2852362:285316028531602853978819Escherichia coli O157:H7 str. EC4115 chromosome, complete genomeglycosyl hydrolase family 253e-1789
NC_013008:2851342:285214028521402852958819Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehydrolase3e-1789
NC_011741:2239637:224237522423752243193819Escherichia coli IAI1 chromosome, complete genomeputative membrane-bound hydrolase4e-1788.6
CP002185:2347413:235142523514252352243819Escherichia coli W, complete genomepredicted hydrolase4e-1788.6
CU928160:2239637:224237522423752243193819Escherichia coli IAI1 chromosome, complete genomeputative membrane-bound hydrolase4e-1788.6
NC_014828:107802:110949110949111866918Ethanoligenens harbinense YUAN-3 chromosome, complete genomeglycoside hydrolase family 254e-1788.6
NC_014328:3294086:331147133114713312391921Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall hydrolase6e-1788.2
NC_011745:2399313:240205124020512402869819Escherichia coli ED1a chromosome, complete genomeputative membrane-bound hydrolase9e-1787.4
NC_012759:2069326:207333820733382074156819Escherichia coli BW2952 chromosome, complete genomeputative hydrolase1e-1687
AC_000091:2185369:218616721861672186985819Escherichia coli W3110 DNA, complete genomepredicted hydrolase1e-1687
NC_010473:2267851:227186322718632272681819Escherichia coli str. K-12 substr. DH10B, complete genomepredicted hydrolase1e-1687
NC_010468:1694729:171134617113461712164819Escherichia coli ATCC 8739, complete genomeglycoside hydrolase family 251e-1687
NC_000913:2180855:218085521808552181673819Escherichia coli K12, complete genomepredicted hydrolase1e-1687
NC_009800:2225182:222518222251822226000819Escherichia coli HS, complete genomeglycosyl hydrolase family 251e-1686.7
NC_007384:2251792:225453022545302255357828Shigella sonnei Ss046, complete genomehypothetical protein2e-1686.3
NC_016822:2341127:234386523438652344683819Shigella sonnei 53G, complete genomehypothetical protein2e-1686.3
NC_014039:1766049:176912617691261770004879Propionibacterium acnes SK137 chromosome, complete genomeglycosyl hydrolase family 253e-1685.9
NC_011740:2220251:223393922339392234856918Escherichia fergusonii ATCC 35469, complete genomeputative membrane-bound hydrolase4e-1685.1
NC_011750:955451:972630972630973448819Escherichia coli IAI39 chromosome, complete genomeputative membrane-bound hydrolase9e-1684
NC_017328:2225418:222924322292432230073831Shigella flexneri 2002017 chromosome, complete genomeputative Lyzozyme M1 (1,4-beta-N-acetylmuramidase)1e-1584
NC_004741:2169877:216987721698772170698822Shigella flexneri 2a str. 2457T, complete genomehypothetical protein1e-1584
NC_008258:2190635:219063521906352191456822Shigella flexneri 5 str. 8401, complete genomehypothetical protein1e-1584
NC_004337:2185282:218835321883532189174822Shigella flexneri 2a str. 301, complete genomehypothetical protein1e-1584
NC_003911:3453764:345734234573423458151810Silicibacter pomeroyi DSS-3, complete genomeglycosyl hydrolase, family 255e-1581.6
NC_013093:3768790:377965337796533780615963Actinosynnema mirum DSM 43827, complete genomeglycoside hydrolase family 259e-1580.9
NC_016516:1751336:175873617587361759569834Propionibacterium acnes TypeIA2 P.acn33 chromosome, completelysozyme M11e-1480.5
NC_015164:1120288:112028811202881121226939Bacteroides salanitronis DSM 18170 chromosome, complete genomeglycoside hydrolase family 251e-1377
NC_010611:208268:233076233076233834759Acinetobacter baumannii ACICU, complete genomeLyzozyme M1 (1,4-beta-N-acetylmuramidase)2e-1272.8
NC_015145:2693749:2697019269701926999372919Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomelysozyme M1 (1,4-beta-N-acetylmuramidase)3e-1272.8
NC_011886:2696671:2701285270128527040922808Arthrobacter chlorophenolicus A6, complete genomeLysozyme9e-1270.9
NC_013715:890784:9061699061699081151947Rothia mucilaginosa DY-18, complete genomelyzozyme M14e-1168.6
NC_013656:1549634:155013015501301551044915Lactococcus lactis subsp. lactis KF147, complete genomephage endolysin4e-1168.6
NC_008530:1454118:147871914787191479597879Lactobacillus gasseri ATCC 33323, complete genomeLyzozyme M1 (1,4-beta-N-acetylmuramidase)8e-1167.4
NC_014828:1987487:199104919910491991999951Ethanoligenens harbinense YUAN-3 chromosome, complete genomeglycoside hydrolase family 259e-1167.4
NC_008541:2989500:2995763299576329982522490Arthrobacter sp. FB24 chromosome 1, complete sequenceglycoside hydrolase, family 251e-1067.4
NC_009004:2055563:206441820644182065275858Lactococcus lactis subsp. cremoris MG1363, complete genomebacteriophage lysin4e-1065.1
NC_005773:5636606:566114256611425661621480Pseudomonas syringae pv. phaseolicola 1448A, complete genomeglycosyl hydrolase, family 252e-0962.8
NC_014643:1986440:2007688200768820091631476Rothia dentocariosa ATCC 17931 chromosome, complete genomelysozyme M17e-0961.2
NC_011773:549500:563675563675564475801Bacillus cereus AH820 chromosome, complete genomeendolysin1e-0860.5
NC_012654:18893:192671926720223957Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceLycA9e-0857.8
NC_015634:652000:6706256706256717221098Bacillus coagulans 2-6 chromosome, complete genome(trans)glycosidase1e-0757
NC_015738:978794:9951409951409990303891Eggerthella sp. YY7918, complete genomesubtilisin-like serine protease6e-0755.1
NC_006087:2326143:234351923435192344244726Leifsonia xyli subsp. xyli str. CTCB07, complete genomelysozyme7e-0754.7
NC_020291:5641444:565902456590245659965942Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeglycoside hydrolase, family 259e-0754.3
NC_013721:1397246:1399328139932814013161989Gardnerella vaginalis 409-05, complete genomeglycosyl hydrolase family 253e-0652.4
NC_016111:1766010:180421218042121804934723Streptomyces cattleya NRRL 8057, complete genomehydrolase4e-0652