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Query: NC_010723:1:2897 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2897, End: 3103, Length: 207

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1:294529453151207Clostridium botulinum B str. Eklund 17B, complete genomeS4 domain protein YaaA1e-23108
NC_020291:1:285528553061207Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRNA-binding S4 domain-containing protein1e-1891.7
NC_015425:2752482:276998027699802770186207Clostridium botulinum BKT015925 chromosome, complete genomeS4 domain-containing protein2e-1581.3
NC_003366:1:330433043510207Clostridium perfringens str. 13, complete genomehypothetical protein1e-1478.6
NC_008261:1:330533053511207Clostridium perfringens ATCC 13124, complete genomeS4 domain protein1e-1478.6
NC_008262:1:312931293335207Clostridium perfringens SM101, complete genomeS4 domain protein1e-1478.6
NC_014328:1:284128413047207Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-1477.4
NC_010520:1:273727372943207Clostridium botulinum A3 str. Loch Maree, complete genomeS4 domain protein6e-1476.3
NC_012658:1:289628963102207Clostridium botulinum Ba4 str. 657 chromosome, complete genomeS4 domain-containing protein7e-1475.9
NC_010516:1:276027602966207Clostridium botulinum B1 str. Okra, complete genomeS4 domain protein1e-1375.5
NC_012563:1:287928793085207Clostridium botulinum A2 str. Kyoto, complete genomeS4 domain protein1e-1375.5
NC_009495:1:273227322938207Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeS4 domain-containing protein1e-1375.5
NC_009697:1:273227322938207Clostridium botulinum A str. ATCC 19397 chromosome, completeS4 domain-containing protein1e-1375.5
NC_009698:1:273227322938207Clostridium botulinum A str. Hall chromosome, complete genomeS4 domain-containing protein1e-1375.5
NC_009699:1:272327232929207Clostridium botulinum F str. Langeland chromosome, complete genomeS4 domain-containing protein1e-1375.5
NC_017297:1:272327232929207Clostridium botulinum F str. 230613 chromosome, complete genomeS4 domain-containing protein1e-1375.5
NC_008593:2527064:254454325445432544749207Clostridium novyi NT, complete genomeS4 domain protein2e-1374.3
NC_011837:1:274627462952207Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-1374.3
NC_009706:1:274627462952207Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-1374.3
NC_021182:1:317031703376207Clostridium pasteurianum BC1, complete genomehypothetical protein2e-1271.2
NC_015687:1:319531953401207Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein2e-1168.2
NC_003030:1:319531953401207Clostridium acetobutylicum ATCC 824, complete genomeSmall conserved protein, ortholog of YAAA B.subtilis2e-1168.2
NC_014654:1:288928893107219Halanaerobium sp. 'sapolanicus' chromosome, complete genomeRNA-binding S4 domain protein4e-1167
NC_006177:3549467:271827182945228Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein7e-1165.9
NC_015519:2739347:285428543075222Tepidanaerobacter sp. Re1 chromosome, complete genomeRNA-binding S4 domain-containing protein1e-1065.5
NC_009089:1:280528053011207Clostridium difficile 630, complete genomeputative RNA-binding mediating protein2e-1064.7
NC_018664:1:285728573069213Clostridium acidurici 9a chromosome, complete genomeRNA-binding S4 domain-containing protein8e-1062.4
NC_015275:1:282728273033207Clostridium lentocellum DSM 5427 chromosome, complete genomeRNA-binding S4 domain protein1e-0962
NC_014973:4630132:464848946484894648686198Geobacter sp. M18 chromosome, complete genomeRNA-binding S4 domain-containing protein2e-0960.8
NC_010814:155834:164012164012164230219Geobacter lovleyi SZ, complete genomeS4 domain protein YaaA1e-0858.5
NC_014152:1:277527752999225Thermincola sp. JR, complete genomeRNA-binding S4 domain protein1e-0858.2
NC_014393:1:299529953252258Clostridium cellulovorans 743B chromosome, complete genomeS4 domain-containing protein YaaA4e-0856.6
NC_013192:2434664:273227322959228Leptotrichia buccalis DSM 1135, complete genomeS4 domain protein YaaA1e-0755.1
NC_018665:1:327232723493222Exiguobacterium antarcticum B7 chromosome, complete genomeS4 domain protein YaaA2e-0754.3
NC_015565:2879603:272527252934210Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeRNA-binding S4 domain-containing protein3e-0753.9
NC_014378:525717:307530753284210Acetohalobium arabaticum DSM 5501 chromosome, complete genomeRNA-binding S4 domain protein7e-0752.8
NC_011297:1357947:137723113772311377446216Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein8e-0752.4
NC_012673:1679744:169743216974321697647216Exiguobacterium sp. AT1b, complete genomeS4 domain protein YaaA1e-0652
NC_021184:1:314731473374228Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein3e-0650.8
NC_010001:1:309930993314216Clostridium phytofermentans ISDg, complete genomeRNA-binding S4 domain protein5e-0650.1
NC_008319:1081614:108923710892371089461225Synechococcus sp. CC9311, complete genomeS4 domain protein5e-0650.1