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Query: NC_010723:1:17110 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 17110, End: 17346, Length: 237

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1:171591715917395237Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-37154
NC_020291:1:171391713917366228Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein3e-29127
NC_014393:19279:206892068920910222Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein1e-1789
NC_010321:562494:572921572921573286366Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehypothetical protein2e-0754.3
NC_014964:557910:568337568337568702366Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein2e-0754.3
NC_019978:2036779:204321420432142043585372Halobacteroides halobius DSM 5150, complete genomeuncharacterized protein with conserved CXXC pairs7e-0752.8
NC_010723:1014334:102450310245031024856354Clostridium botulinum E3 str. Alaska E43, complete genomemolybdopterin oxidoreductase, 4Fe-4S cluster-binding subunit1e-0652
NC_018604:2350054:236113723611372361499363Brachyspira pilosicoli WesB complete genomezinc finger protein6e-0649.7
NC_018607:2231975:224308422430842243446363Brachyspira pilosicoli B2904 chromosome, complete genomezinc finger protein6e-0649.7
NC_014330:888366:899356899356899718363Brachyspira pilosicoli 95/1000 chromosome, complete genomehypothetical protein8e-0649.3
NC_019908:2312194:232066723206672321029363Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein8e-0649.3
NC_012225:2247796:225397622539762254335360Brachyspira hyodysenteriae WA1, complete genomehypothetical protein8e-0649.3