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Query: NC_010723:1967106:1981069 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1981069, End: 1981893, Length: 825

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:182778418277841828602819Clostridium botulinum B str. Eklund 17B, complete genomepropanediol utilization protein PduB1e-148525
NC_019970:2080419:209330420933042094116813Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeethanolamine utilization protein1e-84313
NC_014654:1113116:111772011177201118553834Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein7e-82303
NC_017243:1813158:183259718325971833289693Brachyspira intermedia PWS/A chromosome, complete genomepropanediol utilization protein PduB5e-81301
NC_010320:1949852:196342019634201964217798Thermoanaerobacter sp. X514 chromosome, complete genomemicrocompartments protein3e-80298
NC_014538:985339:990127990127990924798Thermoanaerobacter sp. X513 chromosome, complete genomemicrocompartments protein3e-80298
NC_011601:2139188:218457721845772185389813Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomepropanediol utilization protein PduB3e-80298
NC_008750:450233:468120468120468935816Shewanella sp. W3-18-1, complete genomemicrocompartment protein5e-80297
NC_009438:212476:230560230560231375816Shewanella putrefaciens CN-32 chromosome, complete genomemicrocompartments protein5e-80297
NC_013766:1202713:120591012059101206713804Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein2e-79295
NC_013517:1055854:111496611149661115661696Sebaldella termitidis ATCC 33386, complete genomemicrocompartments protein2e-79295
NC_014633:442755:451374451374452156783Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencemicrocompartments protein3e-79295
NC_012488:1159463:116395711639571164760804Listeria monocytogenes Clip81459, complete genomePduB protein3e-79294
NC_004431:4270305:431211643121164312901786Escherichia coli CFT073, complete genomePutative pduB protein2e-73275
NC_014328:1286407:128903012890301289893864Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization protein2e-72272
NC_008497:1575884:157885515788551579571717Lactobacillus brevis ATCC 367, complete genomePropanediol utilization protein9e-67253
NC_007712:3163000:317593131759313176560630Sodalis glossinidius str. 'morsitans', complete genomeputative propanediol utilization protein3e-47188