Pre_GI: BLASTP Hits

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Query: NC_010723:1967106:1979146 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1979146, End: 1979802, Length: 657

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:182986918298691830525657Clostridium botulinum B str. Eklund 17B, complete genomepropanediol utilization protein6e-113406
NC_014633:442755:458118458118458750633Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencepropanediol utilization protein4e-52204
NC_009253:1381401:139670613967061397407702Desulfotomaculum reducens MI-1 chromosome, complete genomepropanediol utilization protein8e-51199
NC_015565:1163148:118074011807401181387648Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completePropanediol utilization protein1e-49196
NC_007907:456164:469979469979470593615Desulfitobacterium hafniense Y51, complete genomehypothetical protein3e-47188
NC_016613:1877688:188321018832101883902693Vibrio sp. EJY3 chromosome 1, complete sequencepropanediol utilization phosphotransacylase1e-46186
NC_009922:2556033:256385925638592564509651Alkaliphilus oremlandii OhILAs, complete genomePropanediol utilization protein4e-45181
NC_016048:1694631:169463116946311695284654Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein5e-45180
NC_016584:1714507:1721473172147317228521380Desulfosporosinus orientis DSM 765 chromosome, complete genomepropanediol utilization protein5e-45180
NC_010001:1745089:176596917659691766604636Clostridium phytofermentans ISDg, complete genomePropanediol utilization protein9e-45179
NC_016584:4961688:498339549833954983979585Desulfosporosinus orientis DSM 765 chromosome, complete genomepropanediol utilization protein1e-44179
NC_019970:2080419:208648120864812087137657Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepropanediol utilization protein1e-44179
NC_019903:2806466:282780328278032828381579Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,propanediol utilization protein2e-44179
NC_014328:4316008:432189643218964322546651Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepropanediol utilization protein3e-44178
NC_014328:1286407:129723412972341297884651Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepropanediol utilization protein3e-44178
NC_009718:1272296:129376512937651294352588Fervidobacterium nodosum Rt17-B1, complete genomepropanediol utilization protein5e-44177
NC_011742:4655373:465537346553734656059687Escherichia coli S88 chromosome, complete genomehypothetical protein8e-44176
NC_004431:4270305:430728743072874307973687Escherichia coli CFT073, complete genomePutative chormophorylate of CpcA8e-44176
NC_008563:4739333:474085547408554741541687Escherichia coli APEC O1, complete genomeputative propanediol utilization protein8e-44176
NC_016584:5625975:563019056301905630831642Desulfosporosinus orientis DSM 765 chromosome, complete genomepropanediol utilization protein1e-43176
NC_021066:839734:840545840545841237693Raoultella ornithinolytica B6, complete genomepropanediol utilization phosphotransacylase4e-43174
NC_010723:1465097:148506614850661485716651Clostridium botulinum E3 str. Alaska E43, complete genomepropanediol utilization protein5e-42171
NC_009706:830461:848266848266848928663Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment protein3e-42171
NC_011837:830436:848241848241848903663Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-42171
NC_010674:1496500:151485315148531515503651Clostridium botulinum B str. Eklund 17B, complete genomepropanediol utilization protein3e-42171
NC_016584:1998000:2029244202924420306681425Desulfosporosinus orientis DSM 765 chromosome, complete genomepropanediol utilization protein5e-42170
NC_010320:1949852:195700519570051957664660Thermoanaerobacter sp. X514 chromosome, complete genomepropanediol utilization protein2e-41168
NC_014538:985339:996680996680997339660Thermoanaerobacter sp. X513 chromosome, complete genomePropanediol utilization protein2e-41168
NC_018515:3959681:397841439784143978992579Desulfosporosinus meridiei DSM 13257 chromosome, complete genomepropanediol utilization protein6e-41167
NC_014019:3543389:355154335515433552196654Bacillus megaterium QM B1551 chromosome, complete genomeethanolamine utilization protein9e-41166
NC_009633:3933941:394040139404013941057657Alkaliphilus metalliredigens QYMF chromosome, complete genomepropanediol utilization protein1e-39162
NC_009438:212476:224175224175224810636Shewanella putrefaciens CN-32 chromosome, complete genomepropanediol utilization protein1e-39162
NC_008750:450233:461735461735462370636Shewanella sp. W3-18-1, complete genomePropanediol utilization protein1e-39162
NC_012491:5914500:593756559375655938212648Brevibacillus brevis NBRC 100599, complete genomehypothetical protein2e-39162
NC_009698:2171151:217621821762182176868651Clostridium botulinum A str. Hall chromosome, complete genomepropanediol utilization protein PduL-like protein3e-39161
NC_009697:2173000:217599921759992176649651Clostridium botulinum A str. ATCC 19397 chromosome, completepropanediol utilization protein PduL-like protein3e-39161
NC_009495:2244774:224735722473572248007651Clostridium botulinum A str. ATCC 3502 chromosome, complete genomepropanediol utilization protein PduL-like protein3e-39161
NC_004557:1553000:155565815556581556308651Clostridium tetani E88, complete genomehypothetical protein2e-38159
NC_013315:2059007:207357420735742074203630Clostridium difficile CD196 chromosome, complete genomepropanediol/ethanolamine utilization protein1e-38159
NC_017179:2067015:208158220815822082211630Clostridium difficile BI1, complete genomepropanediol utilization phosphotransacylase1e-38159
NC_015275:4493500:449692344969234497546624Clostridium lentocellum DSM 5427 chromosome, complete genomePropanediol utilization protein1e-38159
NC_014654:1113116:113582011358201136467648Halanaerobium sp. 'sapolanicus' chromosome, complete genomePropanediol utilization protein1e-38159
NC_012658:2295536:230487523048752305525651Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative propanediol utilization protein PduL2e-38158
NC_012563:2384500:239076123907612391411651Clostridium botulinum A2 str. Kyoto, complete genomepropanediol utilization protein PduL homolog2e-38158
NC_009699:2287893:229649222964922297142651Clostridium botulinum F str. Langeland chromosome, complete genomepropanediol utilization protein PduL-like protein2e-38158
NC_017297:2288000:229660422966042297254651Clostridium botulinum F str. 230613 chromosome, complete genomepropanediol utilization protein PduL-like protein2e-38158
NC_013517:1055854:112820211282021128837636Sebaldella termitidis ATCC 33386, complete genomePropanediol utilization protein4e-37154
NC_010001:1488000:149851814985181499159642Clostridium phytofermentans ISDg, complete genomePropanediol utilization protein1e-36152
NC_013766:1202713:121258512125851213220636Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein8e-36150
NC_009922:868262:880440880440881075636Alkaliphilus oremlandii OhILAs, complete genomePropanediol utilization protein2e-35149
NC_017243:1813158:182245618224561823091636Brachyspira intermedia PWS/A chromosome, complete genomepropanediol/ethanolamine utilization protein2e-35149
NC_012488:1159463:117063311706331171268636Listeria monocytogenes Clip81459, complete genomePduL protein1e-35149
NC_013192:63111:785527855279187636Leptotrichia buccalis DSM 1135, complete genomePropanediol utilization protein1e-35149
NC_004557:2289135:229637822963782297028651Clostridium tetani E88, complete genomeputative ethanolamine utilization protein3e-34145
NC_014376:1586649:160183616018361602471636Clostridium saccharolyticum WM1 chromosome, complete genomePropanediol utilization protein4e-33141
NC_014614:284005:299842299842300744903Clostridium sticklandii, complete genomePropanediol utilization protein (modular protein)1e-32139
NC_008261:1048515:106361110636111064246636Clostridium perfringens ATCC 13124, complete genomeethanolamine utilization protein2e-32139
NC_003366:1091766:110687511068751107510636Clostridium perfringens str. 13, complete genomeprobable propanediol utilization protein2e-32138
NC_009633:286677:301076301076301714639Alkaliphilus metalliredigens QYMF chromosome, complete genomepropanediol utilization protein1e-30132