Pre_GI: BLASTP Hits

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Query: NC_010723:1967106:1977181 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1977181, End: 1977453, Length: 273

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:183221818322181832490273Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization protein EutN4e-41166
NC_014633:442755:459532459532459798267Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceethanolamine utilization protein EutN/carboxysome structural protein Ccml2e-1580.9
NC_004431:4270305:430950743095074309776270Escherichia coli CFT073, complete genomeEthanolamine utilization protein eutN1e-1478.2
NC_016613:1877688:188140718814071881670264Vibrio sp. EJY3 chromosome 1, complete sequenceputative Ethanolamine utilization protein (eutN-like)2e-1373.9
NC_012488:1159463:117260911726091172872264Listeria monocytogenes Clip81459, complete genomecarbon dioxide concentrating mechanism protein4e-1373.2
NC_013766:1202713:121456112145611214824264Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein4e-1373.2
NC_018870:705900:730835730835731137303Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative ethanolamine utilization protein EutN/carboxysome structural protein Ccml1e-1272
NC_014654:1113116:112663811266381126913276Halanaerobium sp. 'sapolanicus' chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-1272
NC_016048:1694631:169616316961631696426264Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-1168.6
NC_014328:773095:790102790102790377276Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative microcompartment shellprotein4e-1167
NC_009706:830461:850985850985851266282Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein8e-1165.9
NC_011837:830436:850960850960851241282Clostridium kluyveri NBRC 12016, complete genomehypothetical protein8e-1165.9
NC_009922:411434:422262422262422552291Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-1065.5
NC_014376:1586649:160310816031081603380273Clostridium saccharolyticum WM1 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml2e-1064.7
NC_008750:450233:460959460959461237279Shewanella sp. W3-18-1, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml2e-1064.3
NC_019970:2080419:208539220853922085724333Thermoanaerobacterium thermosaccharolyticum M0795, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein2e-1064.3
NC_014538:985339:999072999072999374303Thermoanaerobacter sp. X513 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml5e-1063.2
NC_010320:1949852:195497019549701955272303Thermoanaerobacter sp. X514 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml5e-1063.2
NC_010001:1488000:149920014992001499460261Clostridium phytofermentans ISDg, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml5e-1063.2
NC_009922:868262:881703881703881975273Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml6e-1062.8
NC_009438:212476:223399223399223677279Shewanella putrefaciens CN-32 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml8e-1062.4
NC_012491:5914500:593643059364305936717288Brevibacillus brevis NBRC 100599, complete genomehypothetical protein8e-1062.4
NC_017179:2067015:208299120829912083263273Clostridium difficile BI1, complete genomeethanolamine/propanediol utilization protein1e-0961.6
NC_013315:2059007:207498320749832075255273Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol utilization protein1e-0961.6
NC_003366:1091766:110862211086221108894273Clostridium perfringens str. 13, complete genomeethanolamine utilization protein2e-0961.6
NC_008261:1048515:106535910653591065631273Clostridium perfringens ATCC 13124, complete genomeethanolamine utilization protein EutN2e-0961.6
NC_016584:1998000:203146720314672031760294Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein2e-0961.2
NC_007907:456164:475400475400475690291Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-0961.2
NC_018515:1663912:167768716776871677980294Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein3e-0960.5
NC_016584:5625975:563633856363385636598261Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein4e-0960.1
NC_016584:1714507:172370617237061723999294Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein4e-0960.1
NC_007519:3240864:326553132655313265806276Desulfovibrio alaskensis G20 chromosome, complete genomeethanolamine utilization protein eutN9e-0958.9
NC_009633:286677:303319303319303603285Alkaliphilus metalliredigens QYMF chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0858.5
NC_013440:6045708:606114260611426061420279Haliangium ochraceum DSM 14365, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0858.5
NC_017243:1813158:1819282181928218209431662Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein2e-0858.2
NC_015275:4493500:449596044959604496235276Clostridium lentocellum DSM 5427 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml3e-0857.4
NC_011729:1496848:150827015082701508581312Cyanothece sp. PCC 7424 chromosome, complete genomeethanolamine utilization protein EutN/carboxysome structural protein Ccml5e-0856.6
NC_011726:1665315:167273216727321673037306Cyanothece sp. PCC 8801, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml6e-0856.2
NC_014501:3210323:322010032201003220408309Cyanothece sp. PCC 7822 chromosome, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml5e-0856.2
NC_018664:3009166:304414230441423044426285Clostridium acidurici 9a chromosome, complete genomeethanolamine utilization protein EutN4e-0753.5
NC_009922:2556033:256944525694452569705261Alkaliphilus oremlandii OhILAs, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0652
NC_013192:63111:776177761777886270Leptotrichia buccalis DSM 1135, complete genomeEthanolamine utilization protein EutN/carboxysome structural protein Ccml1e-0652
NC_014614:284005:303652303652303912261Clostridium sticklandii, complete genomeputative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein4e-0650.1