Pre_GI: BLASTP Hits

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Query: NC_010723:1967106:1973753 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1973753, End: 1974301, Length: 549

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:183537018353701835918549Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization protein EutM1e-96352
NC_014654:1113116:113071811307181131266549Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein2e-40164
NC_014614:284005:305288305288305818531Clostridium sticklandii, complete genomehypothetical protein2e-40164
NC_010674:1496500:151120515112051511753549Clostridium botulinum B str. Eklund 17B, complete genomemicrocompartments protein9e-40162
NC_010723:1465097:148141814814181481966549Clostridium botulinum E3 str. Alaska E43, complete genomemicrocompartments protein9e-40162
NC_009922:2556033:256755225675522568094543Alkaliphilus oremlandii OhILAs, complete genomemicrocompartments protein1e-38159
NC_007519:3240864:326083932608393261390552Desulfovibrio alaskensis G20 chromosome, complete genomeputative propanediol utilization protein PduT7e-37153
NC_014328:4316008:432566643256664326214549Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative microcompartment shellprotein5e-37153
NC_016584:5625975:563443956344395634987549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein8e-37152
NC_009253:1381401:139393013939301394475546Desulfotomaculum reducens MI-1 chromosome, complete genomemicrocompartments protein2e-36151
NC_018515:1663912:167934016793401679888549Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein3e-36151
NC_016584:1714507:172535917253591725907549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein5e-36150
NC_016584:1998000:203312020331202033668549Desulfosporosinus orientis DSM 765 chromosome, complete genomecarbon dioxide concentrating mechanism/carboxysome shell protein4e-36150
NC_009633:286677:304958304958305506549Alkaliphilus metalliredigens QYMF chromosome, complete genomemicrocompartments protein2e-34144
NC_009633:3933941:394396339439633944511549Alkaliphilus metalliredigens QYMF chromosome, complete genomemicrocompartments protein3e-34144
NC_017243:1813158:181874018187401819285546Brachyspira intermedia PWS/A chromosome, complete genomemicrocompartments protein3e-34144
NC_007907:456164:473525473525474052528Desulfitobacterium hafniense Y51, complete genomehypothetical protein4e-34144
NC_009706:830461:852902852902853450549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein1e-33142
NC_009706:830461:856877856877857425549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein1e-33142
NC_011837:830436:852877852877853425549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-33142
NC_011837:830436:856852856852857400549Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-33142
NC_018870:705900:732503732503733051549Thermacetogenium phaeum DSM 12270 chromosome, complete genomemicrocompartment protein1e-32139
NC_014633:442755:447872447872448417546Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencemicrocompartments protein1e-32138
NC_011837:830436:858856858856859413558Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-32137
NC_011837:830436:854881854881855438558Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-32137
NC_009706:830461:858991858991859539549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein3e-32137
NC_009706:830461:854915854915855463549Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein3e-32137
NC_010001:1488000:150087715008771501425549Clostridium phytofermentans ISDg, complete genomemicrocompartments protein6e-32136
NC_011740:2072173:207462520746252075179555Escherichia fergusonii ATCC 35469, complete genomeputative Propanediol utilization: polyhedral bodies pduT3e-31134
NC_003366:1091766:110889611088961109450555Clostridium perfringens str. 13, complete genomepropanediol utilization protein2e-29128
NC_004557:2289135:229392922939292294486558Clostridium tetani E88, complete genomeputative ethanolamine utilization protein2e-29128
NC_008261:1048515:106563310656331066187555Clostridium perfringens ATCC 13124, complete genomeethanolamine utilization protein8e-29126
NC_014538:985339:100455110045511005099549Thermoanaerobacter sp. X513 chromosome, complete genomemicrocompartments protein9e-28122
NC_015275:4493500:449541944954194495967549Clostridium lentocellum DSM 5427 chromosome, complete genomemicrocompartments protein2e-25115
NC_016613:1877688:187768818776881878236549Vibrio sp. EJY3 chromosome 1, complete sequencepropanediol utilization protein PduT1e-25115
NC_017179:2067015:208325620832562083807552Clostridium difficile BI1, complete genomeethanolamine/propanediol utilization protein7e-24109
NC_013315:2059007:207524820752482075799552Clostridium difficile CD196 chromosome, complete genomeethanolamine/propanediol utilization protein7e-24109
NC_014654:2277461:229388322938832294437555Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein3e-23107
NC_007519:3240864:326498132649813265529549Desulfovibrio alaskensis G20 chromosome, complete genomepropanediol utilization protein (PduT)-like2e-1891.7
NC_014633:442755:462347462347462907561Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceethanolamine utilization protein2e-1272
NC_011837:830436:8471408471408482341095Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-0755.5
NC_009706:830461:8471688471688482591092Clostridium kluyveri DSM 555 chromosome, complete genomemicrocompartment shellprotein2e-0755.5
NC_014654:1113116:112400511240051124574570Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein9e-0753.1
NC_009922:411434:420510420510420776267Alkaliphilus oremlandii OhILAs, complete genomemicrocompartments protein5e-0650.8
NC_014654:2277461:228709422870942287627534Halanaerobium sp. 'sapolanicus' chromosome, complete genomemicrocompartments protein5e-0650.8