Pre_GI: BLASTP Hits

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Query: NC_010723:1967106:1972357 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1972357, End: 1973556, Length: 1200

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:1836119183611918373181200Clostridium botulinum B str. Eklund 17B, complete genomedhha1 domain protein0708
NC_014393:1590893:1591929159192915931341206Clostridium cellulovorans 743B chromosome, complete genomeAlanyl-tRNA synthetase, class IIc-like9e-101367
NC_008262:784878:8253008253008265021203Clostridium perfringens SM101, complete genomeDHHA1 domain protein1e-99363
NC_016047:2631511:2635834263583426370841251Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completealanine--tRNA ligase2e-51203
NC_006322:2658587:2665677266567726669091233Bacillus licheniformis ATCC 14580, complete genomehypothetical protein1e-50201
NC_006270:2657726:2664816266481626660481233Bacillus licheniformis ATCC 14580, complete genomealanyl-tRNA synthetase1e-50201
NC_015687:1037706:1037706103770610388691164Clostridium acetobutylicum DSM 1731 chromosome, complete genomealanyl-tRNA synthetase-like protein1e-42174
NC_003030:1037885:1037885103788510390481164Clostridium acetobutylicum ATCC 824, complete genomeAlanyl-tRNA synthetase related protein1e-42174
NC_017295:1036348:1037333103733310384961164Clostridium acetobutylicum EA 2018 chromosome, complete genomeAlanyl-tRNA synthetase related protein1e-42174
NC_021182:2360500:2371373237137323725721200Clostridium pasteurianum BC1, complete genomeputative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein1e-40167
NC_013406:5066769:5102668510266851038521185Paenibacillus sp. Y412MC10 chromosome, complete genomeThreonyl/alanyl tRNA synthetase SAD1e-38160
NC_014364:894373:9223109223109234851176Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeAlanyl-tRNA synthetase, class IIc5e-38159
NC_003413:181525:1957861957861970001215Pyrococcus furiosus DSM 3638, complete genomepartial alanyl-tRNA synthetase matches COOH terminus half2e-33143
NC_015387:2042042:2045547204554720467101164Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeThreonyl/alanyl tRNA synthetase SAD5e-29129
NC_000868:1730820:1734494173449417357111218Pyrococcus abyssi GE5, complete genomealanyl-tRNA synthetase related protein (fragment)4e-29129
NC_012883:1603744:1609892160989216111211230Thermococcus sibiricus MM 739, complete genomeAlanyl-tRNA synthetase-related protein1e-27124
NC_015474:723553:7589977589977602111215Pyrococcus sp. NA2 chromosome, complete genomealanyl-tRNA synthetase9e-27121
NC_014623:4662990:4662990466299046641921203Stigmatella aurantiaca DW4/3-1 chromosome, complete genomethreonyl/alanyl tRNA synthetase1e-26121
NC_015732:191554:2107002107002119501251Spirochaeta caldaria DSM 7334 chromosome, complete genomeThreonyl/alanyl tRNA synthetase SAD6e-26119
NC_009776:157311:1713461713461740512706Ignicoccus hospitalis KIN4/I, complete genomealanyl-tRNA synthetase2e-24113
NC_012804:141914:1460911460911473081218Thermococcus gammatolerans EJ3, complete genomeAlanyl-tRNA synthetase-related protein (C-terminus)6e-24112
NC_019791:1272850:1293802129380212965222721Caldisphaera lagunensis DSM 15908 chromosome, complete genomealanine--tRNA ligase/alanyl-tRNA synthetase2e-21103
NC_002754:285759:2916542916542943562703Sulfolobus solfataricus P2, complete genomealanyl-tRNA synthetase3e-21103
NC_017276:1525102:1538048153804815407502703Sulfolobus islandicus REY15A chromosome, complete genomealanyl-tRNA synthetase6e-21102
NC_012588:1619376:1632320163232016350222703Sulfolobus islandicus M.14.25 chromosome, complete genomealanyl-tRNA synthetase5e-21102
NC_012726:1646330:1658450165845016611522703Sulfolobus islandicus M.16.4 chromosome, complete genomealanyl-tRNA synthetase5e-21102
NC_012623:929080:9335989335989363002703Sulfolobus islandicus Y.N.15.51 chromosome, complete genomealanyl-tRNA synthetase4e-21102
NC_017275:1669587:1682532168253216852342703Sulfolobus islandicus HVE10/4 chromosome, complete genomealanyl-tRNA synthetase4e-21102
NC_012622:1679812:1690323169032316930252703Sulfolobus islandicus Y.G.57.14 chromosome, complete genomealanyl-tRNA synthetase4e-21102
NC_012632:1745921:1758218175821817609202703Sulfolobus islandicus M.16.27 chromosome, complete genomealanyl-tRNA synthetase4e-21102
NC_012589:1723897:1736190173619017388922703Sulfolobus islandicus L.S.2.15, complete genomealanyl-tRNA synthetase4e-21102
NC_013769:1739363:1751481175148117541832703Sulfolobus islandicus L.D.8.5 chromosome, complete genomealanyl-tRNA synthetase4e-21102
NC_013192:1941002:1950348195034819529632616Leptotrichia buccalis DSM 1135, complete genomealanyl-tRNA synthetase1e-20101
NC_013922:1911338:1933155193315519359352781Natrialba magadii ATCC 43099 chromosome, complete genomealanyl-tRNA synthetase1e-20100
NC_015435:537483:5395825395825422932712Metallosphaera cuprina Ar-4 chromosome, complete genomealanyl-tRNA synthetase4e-2099.4
NC_014657:1193985:1204789120478912074282640Caldicellulosiruptor owensensis OL chromosome, complete genomealanyl-tRNA synthetase6e-2098.6
NC_007955:1108000:112376611237661124470705Methanococcoides burtonii DSM 6242, complete genomeThreonyl/alanyl tRNA synthetase, SAD2e-1997.1
NC_014122:726070:7460587460587486792622Methanocaldococcus infernus ME chromosome, complete genomealanyl-tRNA synthetase4e-1996.3
NC_019977:1621939:163636916363691637073705Methanomethylovorans hollandica DSM 15978, complete genomeputative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein5e-1995.9
NC_009440:1568500:1577875157787515805892715Metallosphaera sedula DSM 5348 chromosome, complete genomealanyl-tRNA synthetase5e-1995.9
NC_012804:271459:2945282945282972692742Thermococcus gammatolerans EJ3, complete genomeAlanyl-tRNA synthetase (alaS)6e-1995.5
NC_003106:1367404:1371315137131513740292715Sulfolobus tokodaii str. 7, complete genomealanyl-tRNA synthetase1e-1894.7
NC_014374:193391:2439302439302466712742Acidilobus saccharovorans 345-15 chromosome, complete genomeAlanyl-tRNA synthetase2e-1894
NC_016051:1681076:1713482171348217162232742Thermococcus sp. AM4 chromosome, complete genomealanyl-tRNA synthetase2e-1893.6
NC_015865:1260461:1263184126318412659252742Thermococcus sp. 4557 chromosome, complete genomealanyl-tRNA synthetase3e-1893.2
NC_007181:1238806:1241676124167612443992724Sulfolobus acidocaldarius DSM 639, complete genomealanyl-tRNA synthetase4e-1892.8
NC_017295:1809386:1826441182644118290862646Clostridium acetobutylicum EA 2018 chromosome, complete genomealanyl-tRNA synthetase1e-1790.9
NC_003030:1811820:1827028182702818296732646Clostridium acetobutylicum ATCC 824, complete genomealanyl-tRNA synthetase1e-1790.9
NC_015687:1811573:1828628182862818312732646Clostridium acetobutylicum DSM 1731 chromosome, complete genomealanyl-tRNA synthetase1e-1790.9
NC_015216:2276929:2285325228532522880422718Methanobacterium sp. AL-21 chromosome, complete genomealanyl-tRNA synthetase2e-1790.9
NC_011126:1430608:1451996145199614545662571Hydrogenobaculum sp. Y04AAS1, complete genomealanyl-tRNA synthetase2e-1790.5
NC_005823:905500:9268019268019297342934Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130alanyl-tRNA synthetase3e-1789.7
NC_015557:1412917:1432440143244014350102571Hydrogenobaculum sp. 3684 chromosome, complete genomealanyl-tRNA synthetase6e-1789
NC_015587:1414304:1432308143230814348782571Hydrogenobaculum sp. SHO chromosome, complete genomealanyl-tRNA synthetase6e-1789
NC_016627:3295008:3306923330692333095622640Clostridium clariflavum DSM 19732 chromosome, complete genomealanyl-tRNA synthetase6e-1789
NC_013939:1460142:1476545147654514791602616Deferribacter desulfuricans SSM1, complete genomealanyl-tRNA synthetase5e-1789
NC_014205:1331594:1335817133581713385462730Staphylothermus hellenicus DSM 12710 chromosome, complete genomealanyl-tRNA synthetase7e-1788.6
NC_015518:1160430:1170786117078611734942709Acidianus hospitalis W1 chromosome, complete genomealanyl-tRNA synthetase9e-1788.2
NC_014507:1610409:1625968162596816287062739Methanoplanus petrolearius DSM 11571 chromosome, complete genomealanyl-tRNA synthetase1e-1688.2
NC_009033:1042500:1053468105346810561972730Staphylothermus marinus F1, complete genomealanyl-tRNA synthetase2e-1687
NC_014650:603500:606529606529607299771Geobacillus sp. Y4.1MC1 chromosome, complete genomethreonyl/alanyl tRNA synthetase SAD7e-1685.5
NC_013517:2909798:2917507291750729201192613Sebaldella termitidis ATCC 33386, complete genomealanyl-tRNA synthetase7e-1685.5
NC_011766:1035858:1040148104014810428742727Desulfurococcus kamchatkensis 1221n chromosome, complete genomealanyl-tRNA synthetase2e-1584
NC_017954:345430:3586943586943613992706Thermogladius cellulolyticus 1633 chromosome, complete genomealanyl-tRNA synthetase2e-1584
NC_013407:333387:3448303448303475172688Methanocaldococcus vulcanius M7, complete genomealanyl-tRNA synthetase3e-1583.2
NC_003454:1346500:1354132135413213567352604Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeAlanyl-tRNA synthetase5e-1582.4
NC_011969:4065460:4078781407878140814232643Bacillus cereus Q1 chromosome, complete genomealanyl-tRNA synthetase5e-1582.4
NC_011658:4171237:4183421418342141860632643Bacillus cereus AH187 chromosome, complete genomealanyl-tRNA synthetase5e-1582.4
NC_014335:4113154:4124334412433441269762643Bacillus cereus biovar anthracis str. CI chromosome, completealanyl-tRNA synthetase7e-1582
NC_005957:4169610:4181802418180241844442643Bacillus thuringiensis serovar konkukian str. 97-27, completealanyl-tRNA synthetase6e-1582
NC_007530:4176462:4192645419264541952872643Bacillus anthracis str. 'Ames Ancestor', complete genomealanyl-tRNA synthetase1e-1481.3
NC_010337:524605:5420305420305446812652Heliobacterium modesticaldum Ice1, complete genomealanyl-tRNA synthetase1e-1481.3
NC_017200:4191963:4203967420396742066092643Bacillus thuringiensis serovar finitimus YBT-020 chromosome,alanyl-tRNA synthetase2e-1480.1
NC_015954:2764919:279725027972502797996747Halophilic archaeon DL31 chromosome, complete genomeAlanyl-tRNA synthetase, class IIc3e-1479.7
NC_010551:1462827:1465397146539714680212625Burkholderia ambifaria MC40-6 chromosome 1, complete sequencealanyl-tRNA synthetase4e-1479.3
NC_018870:1695588:1699227169922717018632637Thermacetogenium phaeum DSM 12270 chromosome, complete genomealanyl-tRNA synthetase AlaS6e-1479
NC_009440:2093500:209387620938762094583708Metallosphaera sedula DSM 5348 chromosome, complete genomeAla-tRNA(Pro) hydrolase6e-1479
NC_011772:4321117:4330636433063643332782643Bacillus cereus G9842, complete genomealanyl-tRNA synthetase6e-1479
NC_014961:1071424:1076526107652610792522727Desulfurococcus mucosus DSM 2162 chromosome, complete genomealanyl-tRNA synthetase2e-1377
NC_014377:1298806:1311568131156813142102643Thermosediminibacter oceani DSM 16646 chromosome, complete genomealanyl-tRNA synthetase2e-1377
NC_013592:3618248:3622334362233436249612628Dickeya dadantii Ech586, complete genomealanyl-tRNA synthetase2e-1377
NC_018644:137755:144439144439145122684Alpha proteobacterium HIMB59 chromosome, complete genomethreonyl/alanine--tRNA ligase family protein,tRNA synthetase class II family protein3e-1376.6
NC_008698:197294:1980251980252007482724Thermofilum pendens Hrk 5, complete genomealanyl-tRNA synthetase9e-1375.1
NC_014160:869873:8846498846498873752727Thermosphaera aggregans DSM 11486 chromosome, complete genomealanyl-tRNA synthetase1e-1274.7
NC_015680:1275252:127754512775451278186642Pyrococcus yayanosii CH1 chromosome, complete genomealanyl-tRNA synthetase-like protein1e-1274.3
NC_010184:4219257:4229078422907842317202643Bacillus weihenstephanensis KBAB4, complete genomealanyl-tRNA synthetase1e-1274.3
NC_007955:2281070:2297727229772723004982772Methanococcoides burtonii DSM 6242, complete genomealanyl-tRNA synthetase2e-1274.3
NC_014374:344500:368207368207368953747Acidilobus saccharovorans 345-15 chromosome, complete genomeThreonyl/alanyl tRNA synthetase, SAD2e-1273.9
NC_014632:402500:4098294098294124352607Ilyobacter polytropus DSM 2926 chromosome, complete genomealanyl-tRNA synthetase3e-1273.6
NC_020272:1311932:1311932131193213145682637Bacillus amyloliquefaciens IT-45, complete genomealanyl-tRNA ligase5e-1272.4
NC_015460:1687684:1705848170584817084722625Gallibacterium anatis UMN179 chromosome, complete genomealanyl-tRNA synthetase5e-1272.4
NC_020541:2769419:2790751279075127933932643Rhodanobacter sp. 2APBS1, complete genomealanyl-tRNA synthetase7e-1272
NC_018515:989616:1000830100083010034572628Desulfosporosinus meridiei DSM 13257 chromosome, complete genomealanyl-tRNA synthetase1e-1171.2
NC_012622:1579927:158253515825351583245711Sulfolobus islandicus Y.G.57.14 chromosome, complete genomethreonyl/alanyl tRNA synthetase SAD2e-1170.1
NC_015474:538544:555075555075555716642Pyrococcus sp. NA2 chromosome, complete genomealanyl-tRNA synthetase-related protein4e-1169.7
NC_014471:1068000:1082272108227210850162745Ignisphaera aggregans DSM 17230 chromosome, complete genomealanyl-tRNA synthetase1e-1068.2
NC_014205:1257652:128212512821251282844720Staphylothermus hellenicus DSM 12710 chromosome, complete genomeThreonyl/alanyl tRNA synthetase SAD1e-1067.8
NC_016818:749673:7697447697447723712628Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completealanine--tRNA ligase2e-1067.4
NC_013971:2876733:2876733287673328793632631Erwinia amylovora ATCC 49946 chromosome, complete genomealanyl-tRNA synthetase2e-1067
NC_010694:2971170:2971170297117029737972628Erwinia tasmaniensis, complete genomeAlanyl-tRNA synthetase1e-0964.7
NC_008593:1461771:1471092147109214737312640Clostridium novyi NT, complete genomealanyl-tRNA synthetase6e-0962.4
NC_016012:805680:8056808056808083132634Candidatus Arthromitus sp. SFB-rat-Yit, complete genomealanyl-tRNA synthetase7e-0962
NC_021182:2422226:2441004244100424436432640Clostridium pasteurianum BC1, complete genomealanine--tRNA ligase1e-0861.6
NC_014166:401815:4235654235654261172553Arcobacter nitrofigilis DSM 7299 chromosome, complete genomealanyl-tRNA synthetase1e-0861.6
NC_003366:2057656:2057656205765620602952640Clostridium perfringens str. 13, complete genomealanyl-tRNA synthetase2e-0860.8
NC_015722:1050023:1062546106254610651252580Candidatus Midichloria mitochondrii IricVA chromosome, completealanyl-tRNA synthetase2e-0860.5
NC_010655:1606901:1649138164913816519662829Akkermansia muciniphila ATCC BAA-835, complete genomealanyl-tRNA synthetase3e-0859.7
NC_009442:1158268:1178317117831711809352619Streptococcus suis 05ZYH33 chromosome, complete genomealanyl-tRNA synthetase4e-0859.7
NC_004578:5336773:533891153389115339549639Pseudomonas syringae pv. tomato str. DC3000, complete genomealanyl tRNA synthetase-related protein1e-0758.2
NC_007677:1911109:1923136192313619260362901Salinibacter ruber DSM 13855, complete genomealanyl-tRNA synthetase1e-0758.2
NC_014150:1304573:1309320130932013118932574Brachyspira murdochii DSM 12563 chromosome, complete genomealanyl-tRNA synthetase1e-0757.8
NC_014032:1972623:1986541198654119894412901Salinibacter ruber M8 chromosome, complete genomealanyl-tRNA synthetase1e-0757.8
NC_009699:2733529:2747861274786127505002640Clostridium botulinum F str. Langeland chromosome, complete genomealanyl-tRNA synthetase2e-0757
NC_012880:1127997:1139780113978011424072628Dickeya dadantii Ech703, complete genomealanyl-tRNA synthetase5e-0755.8
NC_009465:813816:8402758402758428722598Candidatus Vesicomyosocius okutanii HA, complete genomealanyl-tRNA synthetase1e-0654.7
NC_011025:183287:1864271864271890842658Mycoplasma arthritidis 158L3-1, complete genomealanyl-tRNA synthetase2e-0654.3
NC_011830:3786173:3787542378754237901692628Desulfitobacterium hafniense DCB-2, complete genomealanyl-tRNA synthetase2e-0653.9
NC_007645:713930:719088719088719726639Hahella chejuensis KCTC 2396, complete genomepredicted metal-dependent Hydrolase related to alanyl-tRNA synthetase HxxxH domain2e-0653.5
NC_008782:2062962:2079348207934820819722625Acidovorax sp. JS42, complete genomealanyl-tRNA synthetase2e-0653.5
NC_008095:7172047:7189294718929471919902697Myxococcus xanthus DK 1622, complete genomealanyl-tRNA synthetase7e-0652.4