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Query: NC_010723:1967106:1971694 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1971694, End: 1972218, Length: 525

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:1822963:183745718374571837981525Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein3e-77287
NC_013517:1916020:193402819340281934852825Sebaldella termitidis ATCC 33386, complete genomeprotein of unknown function DUF11133e-1684.7
NC_013171:1677543:169879416987941699570777Anaerococcus prevotii DSM 20548, complete genomeprotein of unknown function DUF11132e-1582
NC_003210:2721559:274332627433262744138813Listeria monocytogenes EGD-e, complete genomehypothetical protein4e-1580.9
NC_015577:383071:383675383675384439765Treponema azotonutricium ZAS-9 chromosome, complete genomemetal dependent phosphohydrolase7e-1580.1
NC_017295:1809386:180938618093861810102717Clostridium acetobutylicum EA 2018 chromosome, complete genomemembrane protein6e-1477
NC_015687:1811573:181157318115731812289717Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein6e-1477
NC_010814:3048441:3090820309082030918481029Geobacter lovleyi SZ, complete genomemetal dependent phosphohydrolase6e-1373.6
NC_017219:2014605:203808620380862038853768Bifidobacterium longum subsp. infantis ATCC 15697, complete genomehypothetical protein1e-1169.3
NC_015589:870804:874087874087874905819Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein3e-1167.8
NC_014638:1333976:133760913376091338388780Bifidobacterium bifidum PRL2010 chromosome, complete genometransporter9e-0856.2
NC_014616:1296287:129812912981291298911783Bifidobacterium bifidum S17 chromosome, complete genomehypothetical protein3e-0754.7
NC_014328:2990790:3007472300747230087671296Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-0753.9
NC_014364:2717865:273510927351092735840732Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeprotein of unknown function DUF11132e-0651.6