Pre_GI: BLASTP Hits

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Query: NC_010723:1379256:1398888 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1398888, End: 1399691, Length: 804

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:967973:970158970158970961804Clostridium perfringens ATCC 13124, complete genomePTS system, mannose/fructose/sorbose family, IIC component4e-81301
NC_011660:2509362:251733925173392518145807Listeria monocytogenes HCC23 chromosome, complete genomePTS system fructose-specific transporter subunit IIC2e-71269
NC_015975:1936504:195133419513341952143810Lactobacillus ruminis ATCC 27782 chromosome, complete genomePTS family mannose/fructose/sorbose porter component IIC2e-68259
NC_015214:437733:475881475881476693813Lactobacillus acidophilus 30SC chromosome, complete genomePTS system mannose-specific transporter subunit IIC6e-66250
NC_014724:439594:476266476266477078813Lactobacillus amylovorus GRL 1112 chromosome, complete genomemannose-specific PTS system component IIC6e-66250
NC_006814:403723:440509440509441330822Lactobacillus acidophilus NCFM, complete genomemannose-specific PTS system component IIC1e-65249
NC_014106:419511:451723451723452532810Lactobacillus crispatus ST1, complete genomePTS system, mannose-specific IIC component3e-65248
NC_018528:1681060:168828016882801689092813Lactobacillus helveticus R0052 chromosome, complete genomePTS system mannose-specific transporter subunit IIC1e-64246
NC_015602:1339067:134521013452101346019810Lactobacillus kefiranofaciens ZW3 chromosome, complete genomePTS system, mannose-specific IIC component2e-64246
NC_005362:1870620:187723618772361878039804Lactobacillus johnsonii NCC 533, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system EIIC, probable mannose specific2e-57222
NC_008530:1775841:178103617810361781839804Lactobacillus gasseri ATCC 33323, complete genomemannose-specific PTS system component IIC4e-57221
NC_013504:1648551:165622716562271657030804Lactobacillus johnsonii FI9785 chromosome, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system EIIC, probably mannose specific6e-57221
NC_013192:469771:484469484469485275807Leptotrichia buccalis DSM 1135, complete genomephosphotransferase system PTS sorbose-specific IIC subunit1e-47190
NC_015061:3147691:314874431487443149541798Rahnella sp. Y9602 chromosome, complete genomePTS system, mannose/fructose/sorbose family, IIC subunit5e-34144
NC_016818:3148000:314928031492803150077798Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completePTS system mannose/fructose/sorbose family transporter subunit IIC5e-34144
NC_017047:3212000:321334632133463214143798Rahnella aquatilis HX2 chromosome, complete genomePTS system mannose-specific transporter subunit IIC5e-34144
NC_012880:2399205:240237424023742403171798Dickeya dadantii Ech703, complete genomePTS system, mannose/fructose/sorbose family, IIC subunit5e-33141
NC_013192:2434664:245282124528212453636816Leptotrichia buccalis DSM 1135, complete genomePTS system, mannose/fructose/sorbose family, IIC subunit6e-31134
NC_009617:4436837:445130444513044452095792Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePTS system mannose/fructose/sorbose family transporter subunit IIC3e-29129
NC_013199:392450:411874411874412707834Lactobacillus rhamnosus Lc 705, complete genomePTS system, mannose-specific IIC component (ManY)6e-29127
NC_016612:2902628:292909729290972929897801Klebsiella oxytoca KCTC 1686 chromosome, complete genomePTS system mannose-specific transporter subunit IIC3e-22105
NC_016023:875416:884578884578885378801Bacillus coagulans 36D1 chromosome, complete genomePTS system sorbose-specific transporter subunit IIC2e-1066.6
NC_013198:394000:4184674184674201551689Lactobacillus rhamnosus GG, complete genomePTS system, mannose-specific IICD component4e-0962
NC_008526:343445:3656743656743672721599Lactobacillus casei ATCC 334, complete genomeMannose-specific PTS system component IICD6e-0858.2
NC_015389:1977736:200605120060512006845795Coriobacterium glomerans PW2 chromosome, complete genomephosphotransferase system PTS sorbose-specific IIC subunit6e-0858.2
NC_009792:4693152:471072147107214711470750Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein2e-0652.8
NC_010067:1116148:112565511256551126425771Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-0652
NC_004631:3841975:386302638630263863775750Salmonella enterica subsp. enterica serovar Typhi Ty2, completeputative PTS system protein5e-0651.6
NC_003198:3855157:387753638775363878285750Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative PTS system protein5e-0651.6
NC_011294:4604283:462807446280744628853780Salmonella enterica subsp. enterica serovar Enteritidis strPTS system transporter subunit C7e-0651.2