Pre_GI: BLASTP Hits

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Query: NC_010723:1379256:1395028 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1395028, End: 1397220, Length: 2193

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014926:165312:1708841708841729982115Thermovibrio ammonificans HB-1 chromosome, complete genomecatalase/peroxidase HPI0745
NC_009439:4267356:4269361426936142715112151Pseudomonas mendocina ymp, complete genomecatalase/peroxidase HPI0853
NC_020125:170245:1784281784281806502223Riemerella anatipestifer RA-CH-2, complete genomeCatalase (peroxidase I)0862
NC_014738:1507641:1514770151477015169922223Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,catalase/peroxidase hpi0862
NC_015312:5876957:5876957587695758791762220Pseudonocardia dioxanivorans CB1190 chromosome, complete genomeCatalase-peroxidase0864
NC_012779:957558:9616549616549638282175Edwardsiella ictaluri 93-146, complete genomecatalase/peroxidase HPI, putative0867
NC_018721:297906:3069553069553092672313Psychroflexus torquis ATCC 700755 chromosome, complete genomecatalase/hydroperoxidase KatG0868
NC_013166:82986:1017441017441038972154Kangiella koreensis DSM 16069, complete genomecatalase/peroxidase HPI0870
NC_012856:2633890:2634833263483326369982166Ralstonia pickettii 12D chromosome 1, complete genomecatalase/peroxidase HPI0872
NC_019940:3863124:3883606388360638857802175Thioflavicoccus mobilis 8321 chromosome, complete genomecatalase/peroxidase HPI0873
NC_012559:2309566:2327402232740223295762175Laribacter hongkongensis HLHK9, complete genomePeroxidase/catalase0849
NC_009434:1743696:1743696174369617459272232Pseudomonas stutzeri A1501, complete genomecatalase/peroxidase HPI0846
NC_015740:1594376:1594526159452615967572232Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completecatalase/peroxidase HPI0846
NC_020911:1353896:1369640136964013718142175Octadecabacter antarcticus 307, complete genomecatalasa-peroxidase KatG0763
NC_018644:137755:1601201601201622732154Alpha proteobacterium HIMB59 chromosome, complete genomecatalase/peroxidase HPI0794
NC_019942:112182:1207121207121229252214Aciduliprofundum sp. MAR08-339, complete genomecatalase/peroxidase HPI0803
NC_014618:4657719:4660624466062446627952172Enterobacter cloacae SCF1 chromosome, complete genomecatalase/peroxidase HPI0822
NC_012559:1228280:1263179126317912654432265Laribacter hongkongensis HLHK9, complete genomePeroxidase/catalase0827
NC_012731:2739964:2739964273996427421412178Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeputative hydroperoxidase I0840
NC_016845:2781438:2781438278143827836152178Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,putative catalase (hydroperoxidase I)0840
NC_009380:2310000:2324947232494723272232277Salinispora tropica CNB-440 chromosome, complete genomecatalase/peroxidase HPI0840
NC_004347:718091:7384947384947407192226Shewanella oneidensis MR-1, complete genomecatalase/peroxidase HPI0842
NC_010995:20181:4866148661508832223Cellvibrio japonicus Ueda107, complete genomecatalase/peroxidase HPI0877
NC_009481:764382:7786257786257808202196Synechococcus sp. WH 7803 chromosome, complete genomecatalase/peroxidase0880
NC_010682:3033646:3035524303552430376892166Ralstonia pickettii 12J chromosome 1, complete sequencecatalase/peroxidase HPI0880
NC_007005:4992730:5010725501072550129952271Pseudomonas syringae pv. syringae B728a, complete genomehaem catalase/peroxidase0946
NC_020210:1704500:1706136170613617083432208Geobacillus sp. GHH01, complete genomecatalase-peroxidase0946
NC_020210:1704500:1737790173779017400002211Geobacillus sp. GHH01, complete genomecatalase-peroxidase0947
NC_006510:1731939:1735015173501517372252211Geobacillus kaustophilus HTA426, complete genomecatalase0949
NC_013510:2288746:2290180229018022924232244Thermomonospora curvata DSM 43183, complete genomecatalase/peroxidase HPI0954
NC_012918:356019:3811433811433833442202Geobacter sp. M21 chromosome, complete genomecatalase/peroxidase HPI0973
NC_003552:1157294:1160900116090011631102211Methanosarcina acetivorans C2A, complete genomecatalase/peroxidase0978
NC_014836:2848000:2859382285938228615772196Desulfurispirillum indicum S5 chromosome, complete genomecatalase/peroxidase HPI01006
NC_014216:2860342:2879709287970928819102202Desulfurivibrio alkaliphilus AHT2 chromosome, complete genomecatalase/peroxidase HPI01021
NC_010674:1390473:1402613140261314048052193Clostridium botulinum B str. Eklund 17B, complete genomecatalase/peroxidase HPI01399
NC_015556:717993:7318497318497341402292Pseudomonas fulva 12-X chromosome, complete genomeCatalase-peroxidase0942
NC_008571:938835:9388359388359410872253Gramella forsetii KT0803, complete genomebifunctional haem catalase-peroxidase0942
NC_008340:1733735:1735184173518417373552172Alkalilimnicola ehrlichei MLHE-1, complete genomecatalase/peroxidase HPI0885
NC_006361:3132000:3133101313310131353202220Nocardia farcinica IFM 10152, complete genomeputative catalase-peroxidase0891
NC_009832:3500000:3513620351362035158182199Serratia proteamaculans 568, complete genomecatalase/peroxidase HPI0907
NC_013947:1956923:1971515197151519737402226Stackebrandtia nassauensis DSM 44728 chromosome, complete genomecatalase/peroxidase HPI0911
NC_011001:2327633:2342310234231023445202211Burkholderia cenocepacia J2315 chromosome 2, complete sequenceperoxidase/catalase KatA0920
NC_002947:4167500:4167633416763341698882256Pseudomonas putida KT2440, complete genomecatalase/peroxidase HPI0921
NC_008543:2220698:2251631225163122538172187Burkholderia cenocepacia HI2424 chromosome 2, complete sequencecatalase/peroxidase HPI0926
NC_008061:190287:2258492258492280352187Burkholderia cenocepacia AU 1054 chromosome 2, complete sequencecatalase/peroxidase HPI0926
NC_010515:2111691:2150170215017021523562187Burkholderia cenocepacia MC0-3 chromosome 2, complete sequencecatalase/peroxidase HPI0926
NC_009921:1813500:1835124183512418373552232Frankia sp. EAN1pec, complete genomecatalase/peroxidase HPI0932
NC_011059:2272747:227531222753122275704393Prosthecochloris aestuarii DSM 271, complete genomeCatalase2e-34147
NC_012108:721005:722913722913723236324Desulfobacterium autotrophicum HRM2, complete genomeKatG5e-1686.7