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Query: NC_010723:1014334:1028461 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1028461, End: 1029024, Length: 564

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020291:4815853:482612748261274826687561Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeresponse regulator8e-68256
NC_009617:4836000:484755248475524848112561Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeresponse regulator receiver/ANTAR domain-containing protein1e-67255
NC_015656:2484749:251097625109762511590615Frankia symbiont of Datisca glomerata chromosome, complete genomeresponse regulator receiver and ANTAR domain-containing protein2e-1478.6
NC_008278:5012000:501680750168075017406600Frankia alni ACN14a, complete genomeTwo-component system transcriptional regulator.6e-1373.9
NC_015565:530000:550893550893551474582Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeresponse regulator receiver and ANTAR domain-containing protein5e-1270.9
NC_009454:713892:730641730641731222582Pelotomaculum thermopropionicum SI, complete genomeresponse regulator1e-1169.7
NC_009633:286677:291290291290291859570Alkaliphilus metalliredigens QYMF chromosome, complete genomeresponse regulator receiver/ANTAR domain-containing protein2e-1168.9
NC_004557:2289135:230627023062702306848579Clostridium tetani E88, complete genomeethanolamine utilization response regulator3e-1168.2
NC_012491:5914500:593353059335305934126597Brevibacillus brevis NBRC 100599, complete genometwo-component response regulator3e-1168.2
NC_008705:3201817:321045032104503211082633Mycobacterium sp. KMS, complete genomeresponse regulator receiver and ANTAR domain protein4e-1064.3
NC_003155:7453994:747144474714447472100657Streptomyces avermitilis MA-4680, complete genometwo-component system response regulator5e-1063.9
NC_013929:7606749:762775876277587628411654Streptomyces scabiei 87.22 chromosome, complete genometwo-component system response regulator6e-1063.9
NC_010572:6463939:648410064841006484756657Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative two-component system response regulator1e-0963.2
NC_021177:1736854:175190317519031752559657Streptomyces fulvissimus DSM 40593, complete genomeResponse regulator receiver and ANTAR domain protein1e-0963.2
NC_016114:5539021:555812155581215558777657Streptomyces flavogriseus ATCC 33331 chromosome, complete genomeresponse regulator receiver and ANTAR domain-containing protein1e-0962.8
NC_015953:1581542:159859415985941599250657Streptomyces sp. SirexAA-E chromosome, complete genomeresponse regulator receiver and ANTAR domain-containing protein1e-0962.8
NC_014158:2561441:257668325766832577300618Tsukamurella paurometabola DSM 20162 chromosome, complete genomeresponse regulator receiver and ANTAR domain protein1e-0962.8
NC_013192:63111:755777557776155579Leptotrichia buccalis DSM 1135, complete genomeresponse regulator receiver and ANTAR domain protein4e-0961.2
NC_015957:8103472:810694181069418107573633Streptomyces violaceusniger Tu 4113 chromosome, complete genomeresponse regulator receiver and ANTAR domain-containing protein8e-0960.1
NC_016906:3006748:301285130128513013537687Gordonia polyisoprenivorans VH2 chromosome, complete genometranscriptional regulator1e-0859.7
NC_018581:3202281:320818632081863208809624Gordonia sp. KTR9 chromosome, complete genomeResponse regulator1e-0859.3
NC_013510:3324978:333571133357113336355645Thermomonospora curvata DSM 43183, complete genomeresponse regulator receiver and ANTAR domain protein1e-0859.3
NC_018524:4049990:406691940669194067488570Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeputative transcriptional regulatory protein pdtaR2e-0859.3
NC_016582:9422650:943842294384229439054633Streptomyces bingchenggensis BCW-1 chromosome, complete genometwo-component system response regulator4e-0857.8
NC_014210:3763940:377846637784663779104639Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,response regulator receiver and ANTAR domain protein4e-0857.8
NC_013521:2254534:225844522584452259125681Sanguibacter keddieii DSM 10542, complete genomeresponse regulator with putative antiterminator output domain5e-0857.4
NC_009454:713892:734645734645735220576Pelotomaculum thermopropionicum SI, complete genomeresponse regulator5e-0857.4
NC_018531:1900619:190838019083801908985606Arthrobacter sp. Rue61a chromosome, complete genometranscriptional regulatory protein PdtaR1e-0756.2
NC_011886:1891077:190025719002571900862606Arthrobacter chlorophenolicus A6, complete genomeresponse regulator receiver and ANTAR domain protein4e-0754.3
NC_013124:1107202:112593511259351126546612Acidimicrobium ferrooxidans DSM 10331, complete genomeresponse regulator receiver and ANTAR domain protein8e-0753.5
NC_008261:1048515:105322710532271053802576Clostridium perfringens ATCC 13124, complete genomeresponse regulator1e-0653.1
NC_003366:1091766:109647510964751097050576Clostridium perfringens str. 13, complete genometwo-component response regulator1e-0653.1
NC_017179:2067015:207157120715712072146576Clostridium difficile BI1, complete genometwo-component response regulator2e-0652.4
NC_013315:2059007:206356320635632064138576Clostridium difficile CD196 chromosome, complete genometwo-component response regulator2e-0652.4
NC_018870:705900:721403721403721999597Thermacetogenium phaeum DSM 12270 chromosome, complete genometranscriptional regulatory protein9e-0650.1