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Query: NC_010723:1014334:1024503 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1024503, End: 1024856, Length: 354

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018607:2231975:224308422430842243446363Brachyspira pilosicoli B2904 chromosome, complete genomezinc finger protein5e-28122
NC_018604:2350054:236113723611372361499363Brachyspira pilosicoli WesB complete genomezinc finger protein6e-28122
NC_014330:888366:899356899356899718363Brachyspira pilosicoli 95/1000 chromosome, complete genomehypothetical protein9e-28122
NC_019908:2312194:232066723206672321029363Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein9e-28122
NC_014964:557910:568337568337568702366Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein7e-27119
NC_010321:562494:572921572921573286366Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehypothetical protein7e-27119
NC_008593:2281896:229313722931372293508372Clostridium novyi NT, complete genomehypothetical protein6e-27119
NC_014150:1423758:144598014459801446339360Brachyspira murdochii DSM 12563 chromosome, complete genomeprotein of unknown function DUF16679e-27118
NC_015425:2528549:254344425434442543815372Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-26117
NC_012225:2247796:225397622539762254335360Brachyspira hyodysenteriae WA1, complete genomehypothetical protein2e-26117
NC_017243:3093393:310641531064153106774360Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein9e-26115
NC_019978:2036779:204321420432142043585372Halobacteroides halobius DSM 5150, complete genomeuncharacterized protein with conserved CXXC pairs1e-24111
NC_014654:1802007:180815918081591808530372Halanaerobium sp. 'sapolanicus' chromosome, complete genomeprotein of unknown function DUF16672e-23107
NC_014624:1675500:172631817263181726689372Eubacterium limosum KIST612 chromosome, complete genomezinc finger protein1e-2098.6
NC_012883:695652:702058702058702423366Thermococcus sibiricus MM 739, complete genomehypothetical protein5e-2096.3
NC_010001:4128034:415054841505484150904357Clostridium phytofermentans ISDg, complete genomeprotein of unknown function DUF16676e-2096.3
NC_014654:1:207292072921106378Halanaerobium sp. 'sapolanicus' chromosome, complete genomeprotein of unknown function DUF16671e-1995.5
NC_000868:269923:279311279311279658348Pyrococcus abyssi GE5, complete genomehypothetical protein3e-1994
NC_011295:246000:264175264175264561387Coprothermobacter proteolyticus DSM 5265, complete genomemolybdopterin oxidoreductase, 4Fe-4S cluster-binding subunit5e-1992.8
NC_006624:1208464:121269812126981213042345Thermococcus kodakarensis KOD1, complete genomemolybdopterin oxidoreductase, 4Fe-4S cluster-binding subunit6e-1992.8
NC_014624:828943:835168835168835533366Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein6e-1889.4
NC_003413:1847935:185711918571191857469351Pyrococcus furiosus DSM 3638, complete genomehypothetical protein5e-1786.3
NC_014393:19279:206892068920910222Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein2e-0754.7
NC_010723:1:171101711017346237Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-0652
NC_010674:1:171591715917395237Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein1e-0652
NC_020291:1:171391713917366228Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein1e-0651.6