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Query: NC_010723:1014334:1016738 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1016738, End: 1017493, Length: 756

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011586:268927:274344274344274664321Acinetobacter baumannii AB0057 chromosome, complete genomearsenical resistance operon repressor2e-0652.8
NC_010410:3606826:368517136851713685503333Acinetobacter baumannii AYE, complete genomearsenical resistence operon repressor2e-0652.8
NC_012780:189949:204441204441204740300Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequenceArsR family transcriptional regulator5e-0755.1
NC_012780:189949:207823207823208092270Eubacterium eligens ATCC 27750 plasmid unnamed, complete sequenceArsR family transcriptional regulator4e-0652
NC_017191:3841170:386595838659583866245288Bacillus amyloliquefaciens XH7 chromosome, complete genomeArsR family transcriptional regulator1e-0653.9
NC_016023:2163000:217759821775982177933336Bacillus coagulans 36D1 chromosome, complete genomeArsR family transcriptional regulator4e-0858.5
UCMB5137:3601629:362861336286133628900288Bacillus atrophaeus UCMB-5137BATR1942_18235; transcriptional regulator, ArsR family protein;(location [3556487:3556775] strand -); from Bacillusatrophaeus 1942, complete genome. [7e-0754.3
NC_004557:2677155:269141226914122691783372Clostridium tetani E88, complete genomehypothetical protein9e-27120
NC_008346:1047500:106479810647981065139342Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeregulator of arsenical resistance3e-0962.4
NC_015589:2100175:211989321198932120222330Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeregulatory protein ArsR7e-0651.2
NC_020410:3801583:382773038277303828017288Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completetranscriptional regulator (ArsR family)3e-0755.5
NC_013921:2375900:239606923960692396476408Thermoanaerobacter italicus Ab9 chromosome, complete genometranscriptional regulator, ArsR family2e-0652.8
NC_017188:3839478:386426638642663864553288Bacillus amyloliquefaciens TA208 chromosome, complete genometranscriptional repressor sdpR1e-0653.5
NC_019842:3852062:387916538791653879452288Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,transcriptional repressor sdpR3e-0755.5