Pre_GI: BLASTP Hits

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Query: NC_010723:1014334:1015444 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 1015444, End: 1016142, Length: 699

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015275:1573916:158816115881611588850690Clostridium lentocellum DSM 5427 chromosome, complete genomeprotein of unknown function DUF5542e-43176
NC_018664:287769:306274306274306954681Clostridium acidurici 9a chromosome, complete genomeprotein of unknown function DUF5544e-36151
NC_010718:2385400:239668023966802397387708Natranaerobius thermophilus JW/NM-WN-LF, complete genomeprotein of unknown function DUF5543e-35148
NC_010337:1051425:107688210768821077565684Heliobacterium modesticaldum Ice1, complete genomemembrane protein, putative1e-33142
NC_015565:2879603:287960328796032880298696Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein3e-33141
NC_015519:2739347:274775027477502748445696Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein3e-32138
NC_009328:3504454:354017435401743540875702Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein6e-32137
NC_014098:3372000:337419533741953374890696Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF5549e-30130
NC_015320:1690047:171059417105941711262669Archaeoglobus veneficus SNP6 chromosome, complete genomehypothetical protein9e-29127
NC_011297:1357947:136668413666841367358675Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein2e-28125
NC_016779:1688946:170944217094421710158717Bacillus cereus F837/76 chromosome, complete genomehypothetical protein8e-28124
NC_015573:1979202:199639919963991997094696Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehypothetical protein7e-28124
NC_002939:805794:808948808948809634687Geobacter sulfurreducens PCA, complete genomehypothetical protein7e-28124
NC_011969:1816746:183385618338561834572717Bacillus cereus Q1 chromosome, complete genomehypothetical protein6e-28124
NC_013939:1841890:185713618571361857828693Deferribacter desulfuricans SSM1, complete genomehypothetical protein4e-27121
NC_011661:1542335:155106715510671551741675Dictyoglomus turgidum DSM 6724, complete genomeprotein of unknown function DUF5547e-27120
NC_007503:2010858:201085820108582011544687Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein5e-26117
NC_008751:1431905:145139014513901452076687Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomeprotein of unknown function DUF5545e-25114
NC_002937:2068117:206811720681172068803687Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completehypothetical protein5e-25114
NC_016629:2784000:278926727892672789956690Desulfovibrio africanus str. Walvis Bay chromosome, completehypothetical protein2e-22105
NC_014150:1099507:111784811178481118546699Brachyspira murdochii DSM 12563 chromosome, complete genomeprotein of unknown function DUF5542e-2099.4
UCMB5137:3660165:367675336767533677436684Bacillus atrophaeus UCMB-5137transport protein9e-2097.1
NC_007760:2611608:262306426230642623819756Anaeromyxobacter dehalogenans 2CP-C, complete genomeprotein of unknown function DUF5543e-1685.1
NC_010376:1433247:143512114351211435813693Finegoldia magna ATCC 29328, complete genomehypothetical protein9e-1684
NC_010610:908452:931522931522932202681Lactobacillus fermentum IFO 3956, complete genomehypothetical protein3e-1582
NC_011145:1732499:175234817523481753103756Anaeromyxobacter sp. K, complete genomeprotein of unknown function DUF5542e-1479.3
NC_016845:4498097:450195245019524502665714Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,putative transport protein4e-1375.1
NC_009648:3720000:372022937202293720909681Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeputative transport protein4e-1374.7
NC_021066:4906239:492232749223274923040714Raoultella ornithinolytica B6, complete genomePutative inner membrane protein YqgA2e-1169.3
NC_020181:4800298:480253048025304803246717Enterobacter aerogenes EA1509E, complete genomehypothetical protein3e-1168.9
NC_011149:3187022:319220331922033192910708Salmonella enterica subsp. enterica serovar Agona str. SL483,YqgA3e-1168.6
NC_004631:3112043:311721231172123117919708Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein3e-1168.6
NC_003198:3126548:313171731317173132424708Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein3e-1168.6
NC_006511:3079512:308469230846923085399708Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein3e-1168.6
NC_011147:3075186:308036630803663081073708Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein3e-1168.6
NC_016832:3100683:310585231058523106559708Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein3e-1168.6
NC_016612:477407:500990500990501706717Klebsiella oxytoca KCTC 1686 chromosome, complete genomehypothetical protein2e-1066.2
NC_013716:5201097:527189352718935272600708Citrobacter rodentium ICC168, complete genomehypothetical protein1e-0860.1
NC_017328:3088907:309144030914403092147708Shigella flexneri 2002017 chromosome, complete genomeNa+ channel or pump2e-0859.7
NC_004741:3041294:304382730438273044534708Shigella flexneri 2a str. 2457T, complete genomeputative transport protein2e-0859.7
NC_004337:3049118:305165130516513052358708Shigella flexneri 2a str. 301, complete genomeputative transport protein2e-0859.7
NC_008253:3122148:312727131272713127978708Escherichia coli 536, complete genomeputative membrane protein YqgA2e-0859.7
NC_010067:4418000:443822444382244438931708Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein2e-0859.3
NC_013364:3701895:370442837044283705135708Escherichia coli O111:H- str. 11128, complete genomeputative inner membrane protein5e-0858.2
NC_009792:4017510:402269940226994023406708Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein2e-0756.2
NC_015663:3466471:348237134823713482982612Enterobacter aerogenes KCTC 2190 chromosome, complete genomehypothetical protein6e-0754.7
NC_013282:3719500:372221837222183722937720Cronobacter turicensis, complete genomeUncharacterized protein yqgA1e-0653.5
NC_009778:259241:287620287620288240621Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein1e-0653.1
NC_020260:263528:282740282740283459720Cronobacter sakazakii Sp291, complete genomehypothetical protein3e-0652